A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease
Department of Quantitative Health Sciences
Adult; Aged; Anemia; Anti-Retroviral Agents; Cohort Studies; Female; Genetic Predisposition to Disease; Genetic Variation; HIV Infections; Hemoglobins; Humans; Leptin; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Single Nucleotide; Prevalence; Promoter Regions, Genetic; Veterans
Genetic Phenomena | Immune System Diseases
To study factors associated with anemia and its effect on survival in HIV-infected persons treated with modern combined antiretroviral therapy (cART), we characterized the prevalence of anemia in the Veterans Aging Cohort Study (VACS) and used a candidate gene approach to identify proinflammatory gene single nucleotide polymorphisms (SNPs) associated with anemia in HIV disease. The study comprised 1597 HIV(+) and 865 HIV(-) VACS subjects with DNA, blood, and annotated clinical data available for analysis. Anemia was defined according to World Health Organization criteria (hemoglobin < 13 g/dL and < 12 g/dL in men and women, respectively). The prevalence of anemia in HIV(+) and HIV(-) subjects was 23.1% and 12.9%, respectively. Independent of HIV status, anemia was present in 23.4% and 8% in blacks and whites, respectively. Analysis of our candidate genes revealed that the leptin -2548 G/A SNP was associated with anemia in HIV(+), but not HIV(-), patients, with the AA and AG genotypes significantly predicting anemia (P < .003 and P < .039, respectively, logistic regression). This association was replicated in an independent cohort of HIV(+) women. Our study provides novel insight into the association between genetic variability in the leptin gene and anemia in HIV(+) individuals.
DOI of Published Version
Vanasse, Gary J.; Jeong, Jee-Yeong; Tate, Janet; Bathulapalli, Harini; Anderson, Damon; Steen, Hanno; Fleming, Mark D.; Mattocks, Kristin M.; Telenti, Amalio; Fellay, Jacques; Justice, Amy C.; and Berliner, Nancy, "A polymorphism in the leptin gene promoter is associated with anemia in patients with HIV disease" (2011). Women’s Health Research Faculty Publications. 561.