Circulating angiogenic factors in singleton vs multiple-gestation pregnancies

UMMS Affiliation

Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Obstetrics

Publication Date


Document Type



Adult; Angiogenic Proteins; Case-Control Studies; Cohort Studies; Female; Gestational Age; Humans; Pre-Eclampsia; Pregnancy; Pregnancy Proteins; Pregnancy Trimester, Third; Pregnancy, High-Risk; Pregnancy, Multiple; Vascular Endothelial Growth Factor Receptor-1


Life Sciences | Medicine and Health Sciences | Obstetrics and Gynecology


OBJECTIVE: Placental soluble fms-like tyrosine kinase-1 may contribute to the pathogenesis of preeclampsia. Here we describe alterations in serum angiogenic factor levels in women with multiple gestation pregnancies, a major preeclampsia risk factor.

STUDY DESIGN: We collected serial serum specimens from 101 pregnant women at high preeclampsia risk between 22 and 36 weeks' gestation. Soluble fms-like tyrosine kinase-1 and placental growth factor were measured by enzyme-linked immunosorbent assay. Women who had preeclampsia or gestational hypertension develop were excluded.

RESULTS: Maternal soluble fms-like tyrosine kinase-1 was higher in multiple gestation (n = 20) compared with high-risk singleton (n = 81) pregnancies for each gestational age range examined. Maternal placental growth factor was significantly higher in multiple vs high-risk singletons before 31 weeks' gestation, whereas the soluble fms-like tyrosine kinase-1/placental growth factor ratio was higher in multiple vs high-risk singletons after 27 weeks.

CONCLUSION: Alterations in circulating angiogenic factors are present in women with multiple gestations and may contribute to higher preeclampsia risk in this population.

DOI of Published Version



Am J Obstet Gynecol. 2008 Feb;198(2):200.e1-7. Link to article on publisher's site

Journal/Book/Conference Title

American journal of obstetrics and gynecology

Related Resources

Link to Article in PubMed

PubMed ID