Title
Comparison of patterns of smoking behavior change among smokers in the Multiple Risk Factor Intervention Trial (MRFIT)
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine
Publication Date
1982-11
Document Type
Article
Subjects
Adult; Behavior; Clinical Trials as Topic; Heart Diseases; Humans; Male; Middle Aged; Risk; *Smoking; Thiocyanates
Disciplines
Life Sciences | Medicine and Health Sciences | Women's Studies
Abstract
The Multiple Risk Factor Intervention Trial (MRFIT) is a 6-year clinical trial for the study of the prevention of heart disease. Twelve thousand eight hundred and sixty-six men in the upper 10–15% of heart attack risk were randomly assigned to Special Intervention (SI) or Usual Care (UC). The SI participants received “risk factor” (hypertension, hypercholesterolemia, and cigarette smoking) intervention at the clinical centers; the UC participants were referred to their usual source of medical care for treatment. Forty percent of SI and 21% of UC smokers at entry reported not smoking at year 4, with lighter smokers in both treatment groups reporting significantly more cessation than heavier smokers. The greatest SI-UC difference in cessation rate was achieved during the first year of the program. The use of serum thiocyanate, an objective indicator of cigarette smoking, avoided problems inherent in self-reported data. Misreporting of smoking status was found in both groups with more occurring among the SI smokers. Cohort analysis revealed that of the smokers who stopped during the first year of the trial, 68% of SI and 57% of UC remained abstinent through the 4-year follow-up. Of the smokers who stopped later in the program the UC had better maintenance rates than the SI.
DOI of Published Version
10.1016/0091-7435(82)90025-1
Source
Prev Med. 1982 Nov;11(6):621-38.
Journal/Book/Conference Title
Preventive medicine
Related Resources
PubMed ID
6761682
Repository Citation
Ockene JK, Hymowitz N, Sexton M, Broste SK. (1982). Comparison of patterns of smoking behavior change among smokers in the Multiple Risk Factor Intervention Trial (MRFIT). Women’s Health Research Faculty Publications. https://doi.org/10.1016/0091-7435(82)90025-1. Retrieved from https://escholarship.umassmed.edu/wfc_pp/340