The J kappa proximal region of the human K locus contains three uncommon V kappa genes which are arranged in opposite transcriptional polarities

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Publication Date


Document Type



Base Sequence; DNA; *Genes, Immunoglobulin; Humans; Immunoglobulin Joining Region; Immunoglobulin Variable Region; Immunoglobulin kappa-Chains; Molecular Sequence Data; Pseudogenes


Life Sciences | Medicine and Health Sciences | Women's Studies


The structure of one of the V kappa gene-containing regions of the locus coding for the human immunoglobulin light chains of the kappa type is described. This so-called B region contains three genes: B1, B2 and B3. According to its sequence B1 is a pseudogene which does not fit well into the present subgroup classification. In lymphoid cell lines the B1 gene region is frequently deleted. B2 and B3 are the previously reported EV15 and V kappa IV genes. The transcriptional polarity of the B1 gene is found to be opposite to one of the B2 and B3 genes. This observation together with the fact that the B region is proximal to the J kappa C kappa gene segment leads to the conclusions to the mechanism of the V kappa-J kappa recombination and allows us to explain the formation of the recombination products in a particular cell line by two consecutive inversions.

DOI of Published Version



Mol Immunol. 1988 May;25(5):479-84.

Journal/Book/Conference Title

Molecular immunology

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