Title

Immunoglobulin genes: generating diversity with AID and UNG

UMMS Affiliation

Department of Molecular Genetics and Microbiology

Publication Date

2002-10-29

Document Type

Article

Subjects

Animals; Cytidine Deaminase; *DNA Glycosylases; *Genes, Immunoglobulin; Mice; N-Glycosyl Hydrolases; Uracil-DNA Glycosidase

Disciplines

Life Sciences | Medicine and Health Sciences | Women's Studies

Abstract

Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.

DOI of Published Version

10.1016/S0960-9822(02)01247-2

Source

Curr Biol. 2002 Oct 29;12(21):R725-7.

Journal/Book/Conference Title

Current biology : CB

Related Resources

Link to article in PubMed

PubMed ID

12419200

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