Immunoglobulin genes: generating diversity with AID and UNG
Department of Molecular Genetics and Microbiology
Animals; Cytidine Deaminase; *DNA Glycosylases; *Genes, Immunoglobulin; Mice; N-Glycosyl Hydrolases; Uracil-DNA Glycosidase
Life Sciences | Medicine and Health Sciences | Women's Studies
Somatic hypermutation and switch recombination of immunoglobulin genes require the activity of the activation-induced deaminase, AID. Recent studies of mice deficient for the uracil-DNA glycosylase UNG, which removes U from DNA, suggest that AID catalyses the deamination of dC to dU during antibody diversification.
DOI of Published Version
Curr Biol. 2002 Oct 29;12(21):R725-7.
Current biology : CB
Storb, Ursula and Stavnezer, Janet, "Immunoglobulin genes: generating diversity with AID and UNG" (2002). Women’s Health Research Faculty Publications. 182.