Title
Chemotherapy responsiveness of human breast tumors in the 6-day subrenal capsule assay: an update
UMMS Affiliation
Department of Medicine, Division of Hematology/Oncology
Publication Date
1983-1
Document Type
Article
Subjects
Animals; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous
Disciplines
Life Sciences | Medicine and Health Sciences | Women's Studies
Abstract
Feasibility of utilizing the 6-day subrenal capsule (SRC) assay to screen drugs against fresh surgical explants of human tumors was confirmed by testing six clinically active chemotherapeutic agents against 141 human breast cancers. Response rates of the six drugs obtained in the assay compared favorably with clinical response rates for the same drugs as reported by Carter (5). The evaluable assay rate for breast tumors was 92% as compared to 89% for gynecologic tumors. Innate drug resistance was indicated with 16 of 57 tumors (28%) which did not respond to any of the six agents tested. Differences in responsiveness of tumors to each agent in a potential three-drug combination of either CMF or CAF suggest that the effectiveness of multiagent therapy might be enhanced if the individual agents of a potential drug combination were selected on the basis of tumor sensitivity to each of the agents in a predictive assay. Although cross-resistance between L-PAM and cytoxan was demonstrated and was statistically significant, 31% of these tumors responded individually to either one or the other agent, suggesting caution in extrapolating concomitance in activity between these two alkylators.
Source
Breast Cancer Res Treat. 1983;3(1):33-8.
Journal/Book/Conference Title
Breast cancer research and treatment
Related Resources
PubMed ID
6871480
Repository Citation
Bogden AE, Costanza ME, Reich SD, Griffin TW, Cobb WR. (1983). Chemotherapy responsiveness of human breast tumors in the 6-day subrenal capsule assay: an update. Women’s Health Research Faculty Publications. Retrieved from https://escholarship.umassmed.edu/wfc_pp/132