Title
Effects on metastases of drug therapy during developing and established tumor immunity
UMMS Affiliation
Department of Medicine, Division of Hematology/Oncology
Publication Date
1983-12-15
Document Type
Article
Subjects
Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Female; Fluorouracil; Immunity, Natural; Immunosuppression; Lung Neoplasms; Mammary Neoplasms, Experimental; Methotrexate; Mice; Mice, Inbred C3H; Neoplasm Transplantation; *Transplantation Immunology
Disciplines
Life Sciences | Medicine and Health Sciences | Women's Studies
Abstract
The effectiveness of treatment with cyclophosphamide, methotrexate and 5-fluorouracil was studied during the s.c. and pulmonary growth of syngeneic C3H/He mammary carcinomas. Treatments with cyclophosphamide, methotrexate and 5-fluorouracil during the primary induction of immunity against a mouse mammary carcinoma inhibited the growth of the tumor, but also inhibited the development of an effective immune resistance against subsequent implants of the same tumor. However, drug treatments of mice with established tumor immunity gave added benefit without detectable depression of immune resistance.
Source
Int J Cancer. 1983 Dec 15;32(6):759-63.
Journal/Book/Conference Title
International journal of cancer. Journal international du cancer
Related Resources
PubMed ID
6654527
Repository Citation
Vaage, J. and Costanza, Mary E., "Effects on metastases of drug therapy during developing and established tumor immunity" (1983). Women’s Health Research Faculty Publications. 131.
https://escholarship.umassmed.edu/wfc_pp/131
