Title
Initial clinical trials of the subrenal capsule assay as a predictor of tumor response to chemotherapy
UMMS Affiliation
Department of Medicine, Division of Hematology/Oncology
Publication Date
1983-12-15
Document Type
Article
Subjects
Animals; Antineoplastic Agents; Clinical Trials; Drug Evaluation, Preclinical; Humans; Kidney; Mice; Neoplasm Transplantation; Neoplasms; Prospective Studies; Retrospective Studies
Disciplines
Life Sciences | Medicine and Health Sciences | Women's Studies
Abstract
Retrospective and prospective clinical trials were performed to determine the usefulness of the 6-day subrenal capsule (SRC) assay for the prediction of response to chemotherapy. Evaluable assays were obtained in 86% of 1000 consecutive specimens obtained from a variety of solid malignancies. Analysis of chemotherapeutic sensitivity in this assay gave reproducible and consistent results. The overall predictive accuracy of the assay in 62 retrospective clinical trials in 55 patients was 85%. Of 37 evaluable patients with chemotherapy refractory cancers treated in a prospective trial with single agent chemotherapy as determined by the assay, 14 (38%) responded. Greater degrees of tumor regression in the assay were associated with a higher probability of clinical response. The SRC assay shows potential value as a rapid predictive test for chemotherapeutic selection on an individual patient basis. However, additional prospective clinical trials are necessary to document its ultimate utility.
Source
Cancer. 1983 Dec 15;52(12):2185-92.
Journal/Book/Conference Title
Cancer
Related Resources
PubMed ID
6357424
Repository Citation
Griffin TW, Bogden AE, Reich SD, Antonelli D, Hunter RE, Ward A, Yu DT, Greene HL, Costanza ME. (1983). Initial clinical trials of the subrenal capsule assay as a predictor of tumor response to chemotherapy. Women’s Health Research Faculty Publications. Retrieved from https://escholarship.umassmed.edu/wfc_pp/127