Department of Medicine, Division of Hematology/Oncology
Electrocardiography; Fluorouracil; Heart; Humans; Male; Middle Aged
Life Sciences | Medicine and Health Sciences | Women's Studies
Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.
Cancer. 1988 Jan 1;61(1):36-45.
Freeman, N. J. and Costanza, Mary E., "5-Fluorouracil-associated cardiotoxicity" (1988). Women’s Health Research Faculty Publications. 116.