Department of Medicine, Division of Hematology/Oncology
Electrocardiography; Fluorouracil; Heart; Humans; Male; Middle Aged
Life Sciences | Medicine and Health Sciences | Women's Studies
Cardiotoxicity manifested as myocardial ischemia is not generally recognized as a side effect of 5-fluorouracil. However, there have been at least 35 cases reported since 1975. In only one of these cases was a somewhat detailed evaluation done to rule out underlying coronary disease. The case reported here of 5-FU cardiotoxicity included an extensive cardiac evaluation to rule out underlying coronary disease and to assess spasm. The literature on 5-FU cardiotoxicity is also reviewed, and its possible mechanisms are analyzed.
DOI of Published Version
Cancer. 1988 Jan 1;61(1):36-45.
Freeman NJ, Costanza ME. (1988). 5-Fluorouracil-associated cardiotoxicity. Women’s Health Research Faculty Publications. https://doi.org/10.1002/1097-0142(19880101)61:1<36::AID-CNCR2820610108>3.0.CO;2-6. Retrieved from https://escholarship.umassmed.edu/wfc_pp/116