The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partners, UMass Memorial Health Care and Baystate Medical Center. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. Other key partners include our patients and communities, foundations, biotechnology and pharmaceutical companies, and members of the venture capital and philanthropic communities. Our goals are to accelerate basic discoveries and develop and support the next generation in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.

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Publications from 2018

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Caste matters: perceived discrimination among women in rural India, Jasmine A. Khubchandani, Apurv Soni, Nisha Fahey, Nitin Raithatha, Anusha Prabhakaran, Nancy Byatt, Tiffany A. Moore Simas, Ajay Phatak, Milagros C. Rosal, Somashekhar Nimbalkar, and Jeroan J. Allison

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Preventing Opioid Use Disorders among Fishing Industry Workers, Angela Walter, Cesar Morocho, Lauren King, John Bartlett, Debra Kelsey, Monica DeSousa, Gretchen Biesecker, and Laura Punnett

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Adherence to 20 Emergency General Surgery Best Practices: Results of a National Survey, Angela M. Ingraham, M. Didem Ayturk, Catarina I. Kiefe, and Heena P. Santry

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Association of Left Atrial Function Index with Atrial Fibrillation and Cardiovascular Disease: The Framingham Offspring Study, Mayank Sardana, Darleen M. Lessard, Bruce A. Barton, Gary F. Mitchell, Aditya Vaze, and David D. McManus

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Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon, Elisa Donnard, Pranitha Vangala, Shaked Afik, Sean M. McCauley, Anetta Nowosielska, Alper Kucukural, Barbara Tabak, Xiaopeng Zhu, William E. Diehl, Patrick McDonel, Nir Yosef, Jeremy Luban, and Manuel Garber

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Should We Use the IMPACT-Model for the Outcome Prognostication of TBI Patients? A Qualitative Study Assessing Physicians' Perceptions, Jesse Moskowitz, Thomas Quinn, Muhammad W. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

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A Systematic Review of Integrated Care Interventions Addressing Perinatal Depression Care in Ambulatory Obstetric Care Settings, Tiffany A. Moore Simas, Michael Flynn, Aimee R. Kroll-Desrosiers, Stephanie M. Carvalho, Len L. Levin, Kathleen Biebel, and Nancy Byatt

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How obstetric settings can help address gaps in psychiatric care for pregnant and postpartum women with bipolar disorder, Nancy Byatt, Lucille Cox, Tiffany A. Moore Simas, Nisha Kini, Kathleen Biebel, Padma Sankaran, Holly A. Swartz, and Linda Weinreb

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Access to Pharmacotherapy Amongst Women with Bipolar Disorder during Pregnancy: a Preliminary Study, Nancy Byatt, Lucille Cox, Tiffany A. Moore Simas, Kathleen Biebel, Padma Sankaran, Holly A. Swartz, and Linda Weinreb

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eFCM: An Enhanced Fuzzy C-Means Algorithm for Longitudinal Intervention Data, Venkata Sukumar Gurugubelli, Zhouzhou Li, Honggang Wang, and Hua (Julia) Fang

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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles, Reka A. Haraszti, Rachael Miller, Marie C. Didiot, Annabelle Biscans, Julia F. Alterman, Matthew R. Hassler, Loic Roux, Dimas Echeverria, Ellen Sapp, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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"Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients, Nils Henninger, Rebecca A. Compton, Muhammad W. Khan, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

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Relation of Orthostatic Hypotension With New-Onset Atrial Fibrillation (From the Framingham Heart Study), Darae Ko, Sarah R. Preis, Steven A. Lubitz, David D. McManus, Ramachandran S. Vasan, Naomi M. Hamburg, Emelia J. Benjamin, and Gary F. Mitchell

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Alcohol and Drug Use among Deaf and Hard-of-Hearing Individuals: A Secondary Analysis of NHANES 2013-2014, Melissa L. Anderson, Bei-Hung Chang, and Nisha Kini

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Geographic Diffusion and Implementation of Acute Care Surgery: An Uneven Solution to the National Emergency General Surgery Crisis, Jasmine A. Khubchandani, Angela M. Ingraham, Vijaya Daniel, M. Didem Ayturk, Catarina I. Kiefe, and Heena Santry

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Disparities in access to emergency general surgery care in the United States, Jasmine A. Khubchandani, Connie Shen, M. Didem Ayturk, Catarina I. Kiefe, and Heena P. Santry

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Does provider advice to increase physical activity differ by activity level among US adults with cardiovascular disease risk factors?, Meera Sreedhara, Valerie J. Silfee, Milagros C. Rosal, Molly E. Waring, and Stephenie C. Lemon

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Gendered Race Modification of the Association Between Chronic Stress and Depression Among Black and White U.S. Adults, Ganga Bey, Molly E. Waring, William M. Jesdale, and Sharina D. Person

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Feasibility and Acceptability of Delivering a Postpartum Weight Loss Intervention via Facebook: A Pilot Study, Molly E. Waring, Tiffany A. Moore Simas, Jessica L. Oleski, Rui Sherry Xiao, Julie A. Mulcahy, Christine N. May, and Sherry L. Pagoto

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SoMe and Self Harm: The use of social media in depressed and suicidal youth, Jennifer L. Carey, Stephanie Carreiro, Brittany Chapman, Nathalie Nader, Peter R. Chai, Sherry L. Pagoto, and Danielle E. Jake-Schoffman

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Wearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach, Keerthi Kumar. Chintha, Premananda Indic, Brittany Chapman, Edward W. Boyer, and Stephanie Carreiro

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Treatment of atrial fibrillation in nursing homes: A place for direct acting oral anticoagulants, Matthew Alcusky and Kate L. Lapane

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Feasibility and acceptability of "healthy directions" a lifestyle intervention for adults with lung cancer, Amanda C. Blok, Traci M. Blonquist, Manan M. Nayak, Darryl Somayaji, Scott E. Crouter, Laura L. Hayman, Yolonda L. Colson, Raphael Bueno, Karen M. Emmons, and Mary E. Cooley

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Feasibility and Acceptability of Mindfulness for Survivors of Homicide and Their Providers, Stephanie W. Hartwell, Jeroan J. Allison, Bonita Jones, Rachel Rodrigues, Clementina Chery, Julianna Andrews, and Carl E. Fulwiler

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Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke, Yunis M. Mayasi, Johanna Helenius, David D. McManus, Richard P. Goddeau Jr, Adalia H. Jun-O'Connell, Majaz Moonis, and Nils Henninger

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Post-hospitalization Treatment Regimen and Readmission for C. difficile Colitis in Medicare Beneficiaries, Charles M. Psoinos, Courtney E. Collins, M. Didem Ayturk, Frederick A. Anderson Jr., and Heena P. Santry

Publications from 2017

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Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme, Apurv Soni, Nisha Fahey, Shyamsundar Raithatha, Anna Handorf, John Bostrom, Ravi Shah, Robert J. Goldberg, Jeroan J. Allison, and David D. McManus

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Change in Cognitive Function in the Month After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transition, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education), Jane S. Saczynski, David D. McManus, Molly E. Waring, Darleen M. Lessard, Milena D. Anatchkova, Jerry H. Gurwitz, Jeroan J. Allison, Arlene S. Ash, Richard H. McManus, David C. Parish, Robert J. Goldberg, and Catarina I. Kiefe

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Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires, Nuray Aslan, Levi B. Watkin, Anna Gil, Rabinarayan Mishra, Fransenio G. Clark, Raymond M. Welsh, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Oxycodone Ingestion Patterns in Acute Fracture Pain With Digital Pills, Peter R. Chai, Stephanie Carreiro, Brendan J. Innes, Brittany Chapman, Kristin L. Schreiber, Robert R. Edwards, Adam W. Carrico, and Edward W. Boyer

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Treatment Effectiveness in Heart Failure with Comorbidity: Lung Disease and Kidney Disease, Jerry H. Gurwitz, David J. Magid, David H. Smith, Grace H. Tabada, Sue Hee. Sung, Larry A. Allen, David D. McManus, Robert J. Goldberg, Mayra Tisminetzky, and Alan S. Go

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Gender and Age Differences in Levels, Types and Locations of Physical Activity among Older Adults Living in Car-Dependent Neighborhoods, Wenjun Li, Elizabeth Procter-Gray, Linda C. Churchill, Scott E. Crouter, Kevin J. Kane, Jie Tian, Patricia D. Franklin, Judith K. Ockene, and Jerry H. Gurwitz

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Racial Differences in Eating Patterns and Food Purchasing Behaviors Among Urban Older Women, Wenjun Li, Gretchen A. Youssef, Elizabeth Procter-Gray, Barbara C. Olendzki, Tasha Cornish, Rashelle B. Hayes, Linda C. Churchill, Kevin J. Kane, Kristen Brown, and Michelle F. Magee

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Lifelong estradiol exposure and risk of depressive symptoms during the transition to menopause and postmenopause, Wendy K. Marsh, Joyce T. Bromberger, Sybil L. Crawford, Katherine Leung, Howard M. Kravitz, John F. Randolph, Hadine Joffe, and Claudio N. Soares

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Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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PRogram In Support of Moms (PRISM): a pilot group randomized controlled trial of two approaches to improving depression among perinatal women, Nancy Byatt, Tiffany A. Moore Simas, Kathleen Biebel, Padma Sankaran, Lori Pbert, Linda Weinreb, Douglas M. Ziedonis, and Jeroan J. Allison

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Neighborhood Socioeconomic Status Predicts Health After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transitions, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education), Lisa Nobel, William M. Jesdale, Jennifer Tjia, Molly E. Waring, David C. Parish, Arlene S. Ash, Catarina I. Kiefe, and Jeroan J. Allison

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Mobility limitations and fear of falling in non-English speaking older Mexican-Americans, Eric G. James, Phillip Conatser, Murat Karabulut, Suzanne G. Leveille, Jeffrey M. Hausdorff, Sarah Cote, Katherine L. Tucker, Bruce A. Barton, Jonathan F. Bean, Soham Al Snih, and Kyriakos S. Markides

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What Families Need and Physicians Deliver: Contrasting Communication Preferences Between Surrogate Decision-Makers and Physicians During Outcome Prognostication in Critically Ill TBI Patients, Thomas Quinn, Jesse Moskowitz, Muhammad A. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

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Outpatient beta-blockers and survival from sepsis: Results from a national cohort of Medicare beneficiaries, Kathleen E. Singer, Courtney E. Collins, Julie Flahive, Allison Wyman, M. Didem Ayturk, and Heena Santry

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Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion, Levi B. Watkin, Rabinarayan Mishra, Anna Gil, Nuray Aslan, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope, Brian G. Pierce, Elisabeth N. Boucher, Kurt H. Piepenbrink, Ejemel Monir, Chelsea A. Rapp, William D. Thomas Jr., Eric J. Sundberg, Zhiping Weng, and Yan Wang

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Prevalence of Long-Term Opioid Use in Long-Stay Nursing Home Residents, Jacob N. Hunnicutt, Stavroula A. Chrysanthopoulou, Christine M. Ulbricht, Anne L. Hume, Jennifer Tjia, and Kate L. Lapane

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The Impact of Nondifferential Exposure Misclassification on the Performance of Propensity Scores for Continuous and Binary Outcomes: A Simulation Study, Mollie E. Wood, Stavroula A. Chrysanthopoulou, Hedvig M. E. Nordeng, and Kate L. Lapane

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Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications, Mai K. Elmallah, Evan Bailey, Michelle Trivedi, Ted M. Kremer, and Lawrence M. Rhein

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Clinical and Echocardiographic Correlates of Left Atrial Function Index: The Framingham Offspring Study, Mayank Sardana, Adedotun Ogunsua, Aditya Vaze, Gerard P. Aurigemma, David D. McManus, and Nisha I. Parikh

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Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications, Michelle Trivedi, Mai K. Elmallah, Evan Bailey, Ted M. Kremer, and Lawrence M. Rhein

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High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells, Yves T. Falanga, Michela Frascoli, Yasin Kaymaz, Catherine Forconi, John Michael Ong'echa, Jeffrey A. Bailey, Leslie J. Berg, and Ann M. Moormann

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Atrial fibrillation, cognition and dementia: A review, Summer Aldrugh, Mayank Sardana, Nils Henninger, Jane S. Saczynski, and David D. McManus

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A survey of practices for the use of electronic health records to support research recruitment, Jihad S. Obeid, Laura M. Beskow, Marie Rape, Ramkiran Gouripeddi, R. Anthony Black, James J. Cimino, Peter J. Embi, Chunhua Weng, Rebecca Marnocha, John B. Buse, and Methods and Process and Informatics Domain Task Force Workgroup

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Acculturation, Depression, and Smoking Cessation: a trajectory pattern recognition approach, Sun S. Kim, Hua (Julia) Fang, Kunsook Bernstein, Zhaoyang Zhang, Joseph R. DiFranza, Douglas Ziedonis, and Jeroan J. Allison

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The association of dietary quality with colorectal cancer among normal weight, overweight and obese men and women: a prospective longitudinal study in the USA, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, and Chyke A. Doubeni

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Predictors of mortality in the elderly after open repair for perforated peptic ulcer disease, Vijaya Daniel, Jason T. Wiseman, Julie Flahive, and Heena Santry

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Implementing a Fee-for-Service Cervical Cancer Screening and Treatment Program in Cameroon: Challenges and Opportunities, Geneva A. DeGregorio, Simon Manga, Edith Kiyang, Florence Manjuh, Leslie Bradford, Preetam Cholli, Richard Wamai, Rebecca Kemunto Ogembo, Zacharie Sando, Yuxin Liu, Lisa Kennedy Sheldon, Kathleen Nulah, Thomas Welty, Edith Welty, and Javier Gordon Ogembo

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Racial Differences in Misclassification of Healthy Eating Based on Food Frequency Questionnaire and 24-Hour Dietary Recalls, Barbara C. Olendzki, Elizabeth Procter-Gray, M. F. Magee, Gretchen A. Youssef, Kevin J. Kane, Linda C. Churchill, Judith K. Ockene, and Wenjun Li

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Music as an Adjunct to Opioid-Based Analgesia, Peter R. Chai, Stephanie Carreiro, Megan L. Ranney, Ketki Karanam, Marko Ahtisaari, Robert Edwards, Kristin L. Schreiber, Lubabah Ben-Ghaly, Timothy B. Erickson, and Edward W. Boyer

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Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System, Reka A. Haraszti, Andrew H. Coles, Neil Aronin, Anastasia Khvorova, and Marie C. Didiot

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Burden of Psychosocial and Cognitive Impairment in Patients With Atrial Fibrillation, John A. Bostrom, Jane S. Saczynski, Alexandra M. Hajduk, Kevin Donahue, Lawrence S. Rosenthal, Clifford Browning, Cynthia Ennis, Kevin C. Floyd, Heather Richardson, Nada Esa, Jessica Ogarek, and David D. McManus

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Integrating Personalized Technology in Toxicology: Sensors, Smart Glass, and Social Media Applications in Toxicology Research, Stephanie Carreiro, Peter R. Chai, Jennifer Carey, Brittany Chapman, and Edward W. Boyer

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Survivors of an Acute Coronary Syndrome With Lower Patient Activation Are More Likely to Experience Declines in Health-Related Quality of Life, Nathaniel A. K. Erskine, Barbara L. Gandek, Molly E. Waring, Rebecca L. Kinney, Darleen M. Lessard, Randolph S. Devereaux, Stavroula A. Chrysanthopoulou, Catarina I. Kiefe, and Robert J. Goldberg

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MIFuzzy Clustering for Incomplete Longitudinal Data in Smart Health, Hua (Julia) Fang

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Clinical phenotypes of perinatal depression and time of symptom onset: analysis of data from an international consortium, Karen T. Putnam, Kristina M. Deligiannidis, Samantha Meltzer-Brody, and Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium

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Statin use and risk of multiple myeloma: An analysis from the Cancer Research Network, Mara M. Epstein, George Divine, Chun R. Chao, Karen E. Wells, Heather Spencer Feigelson, Delia Scholes, Douglas Roblin, Marianne Ulcickas Yood, Lawrence S. Engel, Andrew Taylor, Joan Fortuny, Laurel A. Habel, and Christine C. Johnson

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Association of Changes in Neighborhood-Level Racial Residential Segregation With Changes in Blood Pressure Among Black Adults: The CARDIA Study, Kiarri N. Kershaw, Whitney R. Robinson, Penny Gordon-Larsen, Margaret T. Hicken, David C. Goff, Mercedes R. Carnethon, Catarina I. Kiefe, Stephen Sidney, and Ana V. Diez Roux

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Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type-Specific Differences., Yasin Kaymaz, Cliff I. Oduor, Hongbo Yu, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity, James P. Strassner, Medhi Rashighi, Maggi Ahmed Refat, Jillian M. Richmond, and John E. Harris

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Show Back: Developing and Testing of a Simulation-Based Assessment Method for Identifying Problems in Self-Management of Medications in Older Adults, Alok Kapoor, Laura Burns, Janice B. Foust, Maureen Sarno, Jeanne Callahan-Lydon, Paula Schultz, Jennifer L. Donovan, Abir O. Kanaan, Sybil L. Crawford, Jerry H. Gurwitz, and Kathleen M. Mazor

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Racial Differences in Neighborhood Perceptions and their Influences on Physical Activity among Urban Older Women, Wenjun Li, Elizabeth Procter-Gray, Gretchen A. Youssef, Scott E. Crouter, Jie Cheng, Kristen Brown, Linda C. Churchill, Anthony Clarke, Judith K. Ockene, and Michelle F. Magee

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The Estimated Verbal GCS Subscore in Intubated Traumatic Brain Injury Patients: Is it Really Better, Katarina Cheng, Ribal Bassil, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

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Meta-Analysis of Odds Ratios: Current Good Practices, Bei-Hung Chang and David C. Hoaglin

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The impact of education, country, race and ethnicity on the self-report of postpartum depression using the Edinburgh Postnatal Depression Scale, A. Di Florio, Kristine M. Deligiannidis, S. Meltzer-Brody, and Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium

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Informed consent for next-generation nucleotide sequencing studies: Aiding communication between participants and investigators, Rhonda G. Kost, Stephen M. Poppel, and Barry S. Coller

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Stroke and Circulating Extracellular RNAs, Eric O. Mick, Ravi Shah, Kahraman Tanriverdi, Venkatesh Murthy, Mark Gerstein, Joel Rozowsky, Robert Kitchen, Martin G. Larson, Daniel Levy, and Jane E. Freedman

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Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes, Ravi Shah, Venkatesh Murthy, Michael Pacold, Kirsty Danielson, Kahraman Tanriverdi, Martin G. Larson, Kristina Hanspers, Alexander Pico, Eric O. Mick, Jared Reis, Sarah de Ferranti, Elizaveta Freinkman, Daniel Levy, Udo Hoffmann, Stavroula Osganian, Saumya Das, and Jane E. Freedman

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Broad TCR repertoire and diverse structural solutions for recognition of an immunodominant CD8+ T cell epitope, InYoung Song, Anna Gil, Rabinarayan Mishra, Dario Ghersi, Liisa K. Selin, and Lawrence J. Stern

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RAHI-SATHI Indo-U.S. Collaboration: The Evolution of a Trainee-Led Twinning Model in Global Health Into a Multidisciplinary Collaborative Program, Apurv Soni, Nisha Fahey, Abraham Jaffe, Tiffany A. Moore Simas, Nancy Byatt, Michael Chin, David D. McManus, Michaela Tracey, Jasmine A. Khubchandani, Haley Newman, Allison Earon, Hannah Rosenfield, Anna Handorf, Brittany Novak, John Bostrom, Anindita Deb, Milagros C. Rosal, Patricia A. McQuilkin, Heena Santry, Melissa A. Fischer, and Jeroan J. Allison

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Bioimpedance-Based Heart Failure Deterioration Prediction Using a Prototype Fluid Accumulation Vest-Mobile Phone Dyad: An Observational Study, Chad E. Darling, Silviu Dovancescu, Jane S. Saczynski, Jarno Riistama, Fatima Sert Kuniyoshi, Joseph Rock, Theo E. Meyer, and David D. McManus

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Pain and Pharmacologic Pain Management in Long-Stay Nursing Home Residents, Jacob N. Hunnicutt, Christine M. Ulbricht, Jennifer Tjia, and Kate L. Lapane

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Deaf People's Help-Seeking Following Trauma: Experiences With and Recommendations for the Massachusetts Behavioral Health Care System, Melissa L. Anderson, Kelly S. Wolf Craig, and Douglas M. Ziedonis

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Pharmacogenetics of Ketamine-Induced Emergence Phenomena: A Pilot Study, Edwin N. Aroke, Sybil L. Crawford, and Jennifer R. Dungan

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Hospice Use and Pain Management in Elderly Nursing Home Residents With Cancer, Jacob N. Hunnicutt, Jennifer Tjia, and Kate L. Lapane

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Weight loss support seeking on twitter: the impact of weight on follow back rates and interactions, Christine N. May, Molly E. Waring, Stephanie Rodrigues, Jessica L. Oleski, Effie Olendzki, Martinus M. Evans, Jennifer Carey, and Sherry L. Pagoto

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Defining the 5 and 3 landscape of the Drosophila transcriptome with Exo-seq and RNaseH-seq, Shaked Afik, Osnat Bartok, Maxim N. Artyomov, Alexander A. Shishkin, Sabah Kadri, Mor Hanan, Xiaopeng Zhu, Manuel Garber, and Sebastian Kadener

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Virtual Patient Technology: Engaging Primary Care in Quality Improvement Innovations, Amanda C. Blok, Christine N. May, Rajani S. Sadasivam, and Thomas K. Houston

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Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors, David D. McManus, Jian Rong, Tianxiao Huan, Sean Lacey, Kahraman Tanriverdi, Peter J. Munson, Martin G. Larson, Roby Joehanes, Venkatesh Murthy, Ravi Shah, Jane E. Freedman, and Daniel Levy

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Paucity of Intact Non-Induced Provirus with Early, Long-Term Antiretroviral Therapy of Perinatal HIV Infection, Kaitlin Rainwater-Lovett, Carrie Ziemniak, Douglas Watson, Katherine Luzuriaga, George Siberry, Ann Petru, YaHui Chen, Priyanka Uprety, Margaret M. McManus, Ya-Chi Ho, Susanna L. Lamers, and Deborah Persaud

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Exploring the need for interventions to manage weight and stress during interconception, Jennifer Huberty, Jenn A. Leiferman, Abbey R. Kruper, Lisette T. Jacobson, Molly E. Waring, Jeni L. Matthews, Danielle M. Wischenka, Betty Braxter, and Sara L. Kornfield

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Comparative effectiveness of venous thromboembolism prophylaxis options for the patient undergoing total hip and knee replacement: a network meta-analysis, Alok Kapoor, A. Ellis, N. Shaffer, Jerry H. Gurwitz, A. Chandramohan, J. Saulino, A. Ishak, T. Okubanjo, F. Michota, Elaine M. Hylek, and T. A. Trikalinos

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Association of peripartum synthetic oxytocin administration and depressive and anxiety disorders within the first postpartum year, Aimee Kroll-Desrosiers, Benjamin C. Nephew, Jessica A. Babb, Yurima Guilarte-Walker, Tiffany A. Moore Simas, and Kristina M. Deligiannidis

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Psychometric Development of the Research and Knowledge Scale, Lauren R. Powell, Elizabeth Ojukwu, Sharina D. Person, Jeroan J. Allison, Milagros C. Rosal, and Stephenie C. Lemon

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Attempted and Successful Vacuum-Assisted Vaginal Delivery by Prepregnancy Body Mass Index, Sebastian Ramos, Molly E. Waring, Katherine Leung, Nili S. Amir, Annika L. Bannon, and Tiffany A. Moore Simas

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Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial, Firas H. El-Khatib, Celia Hartigan, Michael J. Thompson, Samir Malkani, J. Paul Lock, David M. Harlan, and Steven J. Russell

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When Rhythm Changes Cause the Blues: New-Onset Atrial Fibrillation during Sepsis, Allan J. Walkey and David D. McManus

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Digital Pills to Measure Opioid Ingestion Patterns in Emergency Department Patients With Acute Fracture Pain: A Pilot Study, Peter R. Chai, Stephanie Carreiro, Brendan J. Innes, Rochelle K. Rosen, Conall O'Cleirigh, Kenneth Mayer, and Edward W. Boyer

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Barriers and Facilitators to Deaf Trauma Survivors' Help-Seeking Behavior: Lessons for Behavioral Clinical Trials Research, Melissa L. Anderson, Kelly S. Wolf Craig, and Douglas M. Ziedonis

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Life Years Gained From Smoking-Cessation Counseling After Myocardial Infarction, Emily M. Bucholz, Adam L. Beckman, Catarina I. Kiefe, and Harlan M. Krumholz

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Drugs and Medical Devices: Adverse Events and the Impact on Women's Health, Jennifer L. Carey, Nathalie Nader, Peter R. Chai, Stephanie Carreiro, Matthew K. Griswold, and Katherine L. Boyle

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Reproductive history and risk of type 2 diabetes mellitus in postmenopausal women: findings from the Women's Health Initiative, Erin S. LeBlanc, Kristopher Kapphahn, Haley Hedlin, Manisha Desai, Nisha I. Parikh, Simin Liu, Donna R. Parker, Matthew Anderson, Vanita Aroda, Shannon Sullivan, Nancy F. Woods, Molly E. Waring, Cora E. Lewis, and Marcia L. Stefanick

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Maternal Age at Childbirth and Parity as Predictors of Longevity Among Women in the United States: The Women's Health Initiative, Aladdin H. Shadyab, Margery L. Gass S, Marcia L. Stefanick, Molly E. Waring, Caroline A. Macera, Linda C. Gallo, Richard A. Shaffer, Sonia Jain, and Andrea Z. LaCroix

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Ages at menarche and menopause and reproductive lifespan as predictors of exceptional longevity in women: the Women's Health Initiative, Aladdin H. Shadyab, Caroline A. Macera, Richard A. Shaffer, Sonia Jain, Linda C. Gallo, Margery Gass, Molly E. Waring, Marcia L. Stefanick, and Andrea Z. LaCroix