Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels
Department of Medicine, Division of Cardiovascular Medicine
Cardiology | Cardiovascular Diseases | Clinical Epidemiology | Translational Medical Research
Atrial fibrillation (AF) is an increasingly prevalent condition and the most common sustained arrhythmia encountered in ambulatory and hospital practice. Several clinical risk factors for AF include age, sex, valvular heart disease, obesity, sleep apnea, heart failure, and hypertension (HTN). Of all the risk factors, HTN is the most commonly encountered condition in patients with incident AF. Hypertension is associated with a 1.8-fold increase in the risk of developing new-onset AF and a 1.5-fold increase in the risk of progression to permanent AF. Hypertension predisposes to cardiac structural changes that influence the development of AF such as atrial remodeling. The renin angiotensin aldosterone system has been demonstrated to be a common mechanistic link in the pathogenesis of HTN and AF. Importantly, HTN is one of the few modifiable AF risk factors, and guideline-directed management of HTN may reduce the incidence of AF.
DOI of Published Version
Methodist Debakey Cardiovasc J. 2015 Oct-Dec;11(4):228-34. doi: 10.14797/mdcj-11-4-228. Link to article on publisher's site
Methodist DeBakey cardiovascular journal
Ogunsua, Adedotun; Shaikh, Amir Y.; Ahmed, Mohamed; and McManus, David D., "Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels" (2015). UMass Center for Clinical and Translational Science Supported Publications. 95.