UMMS Affiliation
Department of Medicine, Division of Cardiovascular Medicine; Department of Quantitative Health Sciences
Publication Date
2016-03-21
Document Type
Article
Disciplines
Cardiology | Cardiovascular Diseases | Genetics and Genomics | Translational Medical Research
Abstract
BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.
METHODS: We analyzed 64,901 individuals of European ancestry without previous AF at baseline and with lipid gene scores. Lipid-specific gene scores, based on loci significantly associated with lipid levels, were calculated. Additionally, non-pleiotropic gene scores for high-density lipoprotein cholesterol (HDLc) and low-density lipoprotein cholesterol (LDLc) were calculated using SNPs that were only associated with the specific lipid fraction. Cox models were used to estimate the hazard ratio (HR) and 95% confidence intervals (CI) of AF per 1-standard deviation (SD) increase of each lipid gene score.
RESULTS: During a mean follow-up of 12.0 years, 5434 (8.4%) incident AF cases were identified. After meta-analysis, the HDLc, LDLc, total cholesterol, and triglyceride gene scores were not associated with incidence of AF. Multivariable-adjusted HR (95% CI) were 1.01 (0.98-1.03); 0.98 (0.96-1.01); 0.98 (0.95-1.02); 0.99 (0.97-1.02), respectively. Similarly, non-pleiotropic HDLc and LDLc gene scores showed no association with incident AF: HR (95% CI) = 1.00 (0.97-1.03); 1.01 (0.99-1.04).
CONCLUSIONS: In this large cohort study of individuals of European ancestry, gene scores for lipid fractions were not associated with incident AF.
Keywords
UMCCTS funding
Rights and Permissions
Copyright © 2016 Norby et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI of Published Version
10.1371/journal.pone.0151932
Source
PLoS One. 2016 Mar 21;11(3):e0151932. doi: 10.1371/journal.pone.0151932. eCollection 2016. Link to article on publisher's site
Journal/Book/Conference Title
PloS one
Related Resources
PubMed ID
26999784
Repository Citation
Norby, Faye L. and McManus, David D., "Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium" (2016). UMass Center for Clinical and Translational Science Supported Publications. 82.
https://escholarship.umassmed.edu/umccts_pubs/82
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Included in
Cardiology Commons, Cardiovascular Diseases Commons, Genetics and Genomics Commons, Translational Medical Research Commons