Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative
Department of Quantitative Health Sciences; Department of Medicine, Division of Preventive and Behavioral Medicine; UMass Worcester Prevention Research Center
Translational Medical Research | Women's Health
OBJECTIVE: To examine whether weight history and weight transitions over adult lifespan contribute to physical impairment among postmenopausal women.
DESIGN: BMI categories were calculated among postmenopausal women who reported their weight and height at age 18 years. Multiple-variable logistic regression was used to determine the association between BMI at age 18 years and BMI transitions over adulthood on severe physical impairment (SPI), defined as scoring < 60 on the Physical Functioning subscale of the Rand thirty-six-item Short-Form Health Survey.
SETTING: Participants were part of the Women's Health Initiative Observational Study (WHI OS), where participants' health was followed over time via questionnaires and clinical assessments.
SUBJECTS: Postmenopausal women (n 76 016; mean age 63.5 (sd 7.3) years).
RESULTS: Women with overweight (BMI=25.0-29.9 kg/m2) or obesity (BMI > /=30.0 kg/m2) at 18 years had greater odds (OR (95 % CI)) of SPI (1.51 (1.35, 1.69) and 2.14 (1.72, 2.65), respectively) than normal-weight (BMI=18.5-24.9 kg/m2) counterparts. Transitions from normal weight to overweight/obese or to underweight (BMI < 18.5 kg/m2) were associated with greater odds of SPI (1.97 (1.84, 2.11) and 1.35 (1.06, 1.71), respectively) compared with weight stability. Shifting from underweight to overweight/obese also had increased odds of SPI (1.52 (1.11, 2.09)). Overweight/obese to normal BMI transitions resulted in a reduced SPI odds (0.52 (0.39, 0.71)).
CONCLUSIONS: Higher weight history and transitions into higher weight classes were associated with higher likelihood of SPI, while transitioning into lower weight classes for those with overweight/obesity was protective among postmenopausal women.
UMCCTS funding, BMI, Body weight, Disability, Physical function, Physical impairment, Weight change
DOI of Published Version
Public Health Nutr. 2016 Jun 8:1-9. Link to article on publisher's site
Public health nutrition
Wanigatunga AA, Sourdet SS, Lamonte MJ, Waring ME, Nassir R, Garcia L, Bea JW, Seguin RA, Ockene JK, Sarto GE, Stefanick ML, Limacher MC, Manini T, Women’s Health Initiative Investigators. (2016). Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative. UMass Center for Clinical and Translational Science Supported Publications. https://doi.org/10.1017/S1368980016001415. Retrieved from https://escholarship.umassmed.edu/umccts_pubs/79