Physical impairment and body weight history in postmenopausal women: the Women's Health Initiative
Authors
Wanigatunga, Amal A.Sourdet, Sandrine S.
Lamonte, Michael J.
Waring, Molly E.
Nassir, Rami
Garcia, Lorena
Bea, Jennifer W.
Seguin, Rebecca A.
Ockene, Judith K.
Sarto, Gloria E.
Stefanick, Marcia L.
Limacher, Marian C.
Manini, Todd
Women’s Health Initiative Investigators
UMass Chan Affiliations
Prevention Research CenterDepartment of Medicine, Division of Preventive and Behavioral Medicine
Department of Quantitative Health Sciences
Document Type
Journal ArticlePublication Date
2016-06-08Keywords
UMCCTS fundingBMI
Body weight
Disability
Physical function
Physical impairment
Weight change
Translational Medical Research
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE: To examine whether weight history and weight transitions over adult lifespan contribute to physical impairment among postmenopausal women. DESIGN: BMI categories were calculated among postmenopausal women who reported their weight and height at age 18 years. Multiple-variable logistic regression was used to determine the association between BMI at age 18 years and BMI transitions over adulthood on severe physical impairment (SPI), defined as scoring < 60 on the Physical Functioning subscale of the Rand thirty-six-item Short-Form Health Survey. SETTING: Participants were part of the Women's Health Initiative Observational Study (WHI OS), where participants' health was followed over time via questionnaires and clinical assessments. SUBJECTS: Postmenopausal women (n 76 016; mean age 63.5 (sd 7.3) years). RESULTS: Women with overweight (BMI=25.0-29.9 kg/m2) or obesity (BMI > /=30.0 kg/m2) at 18 years had greater odds (OR (95 % CI)) of SPI (1.51 (1.35, 1.69) and 2.14 (1.72, 2.65), respectively) than normal-weight (BMI=18.5-24.9 kg/m2) counterparts. Transitions from normal weight to overweight/obese or to underweight (BMI < 18.5 kg/m2) were associated with greater odds of SPI (1.97 (1.84, 2.11) and 1.35 (1.06, 1.71), respectively) compared with weight stability. Shifting from underweight to overweight/obese also had increased odds of SPI (1.52 (1.11, 2.09)). Overweight/obese to normal BMI transitions resulted in a reduced SPI odds (0.52 (0.39, 0.71)). CONCLUSIONS: Higher weight history and transitions into higher weight classes were associated with higher likelihood of SPI, while transitioning into lower weight classes for those with overweight/obesity was protective among postmenopausal women.Source
Public Health Nutr. 2016 Jun 8:1-9. Link to article on publisher's site
DOI
10.1017/S1368980016001415Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50509PubMed ID
27269298Related Resources
ae974a485f413a2113503eed53cd6c53
10.1017/S1368980016001415