Cortisol response to the Trier Social Stress Test in pregnant women at risk for postpartum depression
Department of Psychiatry; Department of Quantitative Health Sciences
Female Urogenital Diseases and Pregnancy Complications | Mental Disorders | Obstetrics and Gynecology | Psychiatry | Translational Medical Research | Women's Health
Antepartum depression and anxiety are risk factors for postpartum depression (PPD). Postpartum abnormalities in hypothalamic-pituitary-adrenal (HPA) reactivity are associated with PPD. It is not known if antepartum HPA abnormalities exist in women at risk for PPD (AR-PPD). We measured salivary cortisol response to the Trier Social Stress Test (TSST) in 44 (24 AR-PPD, 20 healthy comparison) pregnant women. Depression and anxiety were measured using the Edinburgh Postnatal Depression Scale (EPDS) and Spielberger State-Trait Anxiety Inventory-State (STAI-S). We analyzed longitudinal changes in cortisol using generalized estimating equation methods to control for the correlation within subjects at the six TSST time points. Group differences in area under the curve (AUC) were examined. A majority (70.8 %) of the AR-PPD had prior depression. EPDS total score was higher in AR-PPD vs. comparison women (mean EPDS = 9.8 +/- 4.9 vs. mean EPDS = 2.4 +/- 2.0 respectively, p < 0.001). Mean STAI-S total score was higher in AR-PPD vs. comparison women at all TSST time points and over time (z = 2.71, df = 1, p = 0.007). There was no significant difference in cortisol concentration over time between groups. We observed no detectable difference in cortisol response to psychosocial stress induced by the TSST despite clinically significant between-group differences in current/past depression and current symptomatology.
DOI of Published Version
Arch Womens Ment Health. 2016 Mar 7. Link to article on publisher's site
Archives of women's mental health
Deligiannidis, Kristina M.; Kroll-Desrosiers, Aimee R.; Svenson, Abby E.; Jaitly, Nina; Barton, Bruce A.; Hall, Janet E.; and Rothschild, Anthony J., "Cortisol response to the Trier Social Stress Test in pregnant women at risk for postpartum depression" (2016). UMass Center for Clinical and Translational Science Supported Publications. 72.