Genetic variation in stearoyl-CoA desaturase 1 is associated with metabolic syndrome prevalence in Costa Rican adults
Document Type
Journal ArticlePublication Date
2011-12-01Keywords
Adipose TissueAdolescent
Adult
Aged
Aged, 80 and over
Alleles
Costa Rica
Fatty Acids
Female
Gene Expression Regulation
Genotype
Haplotypes
Humans
Male
Metabolic Syndrome X
Middle Aged
*Polymorphism, Single Nucleotide
Prevalence
Stearoyl-CoA Desaturase
Young Adult
alpha-Linolenic Acid
UMCCTS funding
Nutritional and Metabolic Diseases
Metadata
Show full item recordAbstract
Stearoyl-CoA desaturase 1 (SCD1) activity, a key regulator of lipid metabolism, may be associated with the development of metabolic syndrome (MetS). We examined the association of genetic variation in the SCD1 gene with the occurrence of MetS and its five components in a population of Costa Rican adults (n = 2152; mean age, 58 y; range, 18-86 y). Associations of tag single nucleotide polymorphisms (tagSNP) of the SCD1 gene with prevalence of MetS and its five components were analyzed by use of log-Poisson models with robust variance estimates and linear regression models, respectively. The likelihood ratio was used to test potential gene-fatty acid interactive effects with adipose tissue alpha-linolenic acid. One tagSNP (rs1502593) was significantly associated with an increased prevalence of MetS in the total study sample. Compared with the common homozygous CC genotype, the CT and TT genotypes for rs1502593 were associated with higher prevalence ratios (PR) of MetS for CT vs. CC: [PR = 1.22 (95% CI = 1.03, 1.44)] and for TT vs. CC [PR = 1.24 (95% CI = 1.01, 1.52)]. Among women, we observed borderline positive associations between systolic blood pressure and fasting blood sugar levels and rs1502593 (P = 0.05 and 0.06). Compared to the common haplotype (frequency >/= 5%) with no minor alleles of SCD1 tagSNP, the other two observed common haplotypes carrying the rs1502593 minor allele were significantly associated with elevated prevalence of MetS. No gene-fatty acid interactive effects were observed. Our results suggest that genetic variation in the SCD1 gene may play a role in the development of MetS.Source
J Nutr. 2011 Dec;141(12):2211-8. Epub 2011 Nov 2. doi 10.3945/jn.111.143503
DOI
10.3945/jn.111.143503Permanent Link to this Item
http://hdl.handle.net/20.500.14038/50478PubMed ID
22049297Related Resources
ae974a485f413a2113503eed53cd6c53
10.3945/jn.111.143503