Title

BMP Signaling Promotes Neural Crest Identity and Accelerates Melanoma Onset

UMMS Affiliation

Program in Molecular Medicine; Department of Molecular, Cell and Cancer Biology; Department of Dermatology; Graduate School of Biomedical Sciences

Publication Date

2021-08-01

Document Type

Article

Disciplines

Cancer Biology | Dermatology | Neoplasms | Skin and Connective Tissue Diseases | Translational Medical Research

Abstract

Currently, little is known about specific factors and pathways that act to initially promote neural crest identity during tumor initiation. Recently, GDF6-activated BMP signaling was shown to regulate differentiation and survival both in melanomas and during melanocyte development. Together, these results have implicated BMP signaling as a key regulator of neural crest and melanocyte programs in normal and pathologic states of the melanocyte lineage. However, it is unknown whether BMP signaling plays a role early in melanoma initiation and progression.

Keywords

UMCCTS funding

DOI of Published Version

10.1016/j.jid.2021.01.021

Source

Gramann AK, Frantz WT, Dresser K, Gomes CBF, Lian CG, Deng A, Ceol CJ. BMP Signaling Promotes Neural Crest Identity and Accelerates Melanoma Onset. J Invest Dermatol. 2021 Aug;141(8):2067-2070.e1. doi: 10.1016/j.jid.2021.01.021. Epub 2021 Feb 19. PMID: 33610560. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of investigative dermatology

Related Resources

Link to Article in PubMed

PubMed ID

33610560

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