Peripartum depression: Does risk versus diagnostic status impact mother-infant bonding and perceived social support
Department of Population and Quantitative Health Sciences
Diagnosis | Maternal and Child Health | Obstetrics and Gynecology | Psychiatry | Psychiatry and Psychology | Translational Medical Research | Women's Health
BACKGROUND: Peripartum depression (PND) impairs mother-infant boding and perceived social support, yet limited research has examined if women at-risk for PND (AR-PND) also experience impairment. We examined if pregnant women AR-PND, women with PND, and healthy comparison women (HCW) differed in their mother-infant bonding and social support. As PND is highly comorbid with anxiety, we also examined if peripartum anxiety impacted postpartum diagnosis of PND.
METHODS: A total of 144 pregnant women AR-PND or euthymic were assessed twice antepartum and twice postpartum. We utilized regression models to examine the impact of PND risk group status and diagnostic status on mother-infant bonding and perceived social support postpartum. We conducted a sensitivity analysis using a generalized estimating equations model to determine if anxiety (Hamilton Anxiety Rating Scale, HAM-A) across all four time points was associated with the postpartum diagnosis of PND.
RESULTS: Women AR-PND experienced significantly worse mother-infant bonding compared to HCW (p = .03). Women diagnosed with PND experienced significantly worse mother-infant bonding and social support compared to HCW (p = .001, p = .002, respectively) and to those who were at-risk for but did not develop PND (p = .02, p = .008, respectively). HAM-A severity at each visit was associated with PND diagnosis status, where each increase in HAM-A was associated with 15% increased odds of being diagnosed with PND postpartum.
CONCLUSIONS: Both women AR-PND and those with PND experience worse mother-infant bonding. Peripartum anxiety should also be assessed as it represents a marker for later PND.
anxiety, depression, mother-infant relationship, peripartum, postpartum, social support, UMCCTS funding
DOI of Published Version
Hare MM, Kroll-Desrosiers A, Deligiannidis KM. Peripartum depression: Does risk versus diagnostic status impact mother-infant bonding and perceived social support? Depress Anxiety. 2021 Apr;38(4):390-399. doi: 10.1002/da.23121. Epub 2020 Dec 7. PMID: 33615587; PMCID: PMC8026554. Link to article on publisher's site
Depression and anxiety
Hare MM, Kroll-Desrosiers A, Deligiannidis KM. (2021). Peripartum depression: Does risk versus diagnostic status impact mother-infant bonding and perceived social support. UMass Center for Clinical and Translational Science Supported Publications. https://doi.org/10.1002/da.23121. Retrieved from https://escholarship.umassmed.edu/umccts_pubs/240