Title

The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV

UMMS Affiliation

Program in Molecular Medicine; UMass Center for Clinical and Translational Science

Publication Date

2020-05-01

Document Type

Article

Disciplines

Immunology of Infectious Disease | Immunopathology | Infectious Disease | Pediatrics | Translational Medical Research | Virus Diseases | Viruses

Abstract

Several assays have been developed to measure and characterise the replication-competent HIV-1 reservoir, which constitutes the barrier to cure. To date, the application of these assays to studies in children and in limited-resource settings has been minimal, primarily because of their expense, the large required blood volumes, and labour-intensive technologies. For children vertically infected with HIV-1 who initiated suppressive antiretroviral therapy (ART) regimens in infancy, HIV-1-specific antibody concentrations are associated with viral persistence and could be used to estimate the size of the residual latent reservoir on ART. This strategy could be particularly useful for screening children on suppressive ART for enrolment into therapeutic vaccine trials and other protocols aimed at achieving HIV-1 remission.

Keywords

UMCCTS funding

DOI of Published Version

10.1016/S2352-3018(20)30100-4

Source

Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K. The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV. Lancet HIV. 2020 May;7(5):e359-e365. doi: 10.1016/S2352-3018(20)30100-4. PMID: 32386722. Link to article on publisher's site

Journal/Book/Conference Title

The lancet. HIV

Related Resources

Link to Article in PubMed

PubMed ID

32386722

Link to Full Text

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