The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV
Program in Molecular Medicine; UMass Center for Clinical and Translational Science
Immunology of Infectious Disease | Immunopathology | Infectious Disease | Pediatrics | Translational Medical Research | Virus Diseases | Viruses
Several assays have been developed to measure and characterise the replication-competent HIV-1 reservoir, which constitutes the barrier to cure. To date, the application of these assays to studies in children and in limited-resource settings has been minimal, primarily because of their expense, the large required blood volumes, and labour-intensive technologies. For children vertically infected with HIV-1 who initiated suppressive antiretroviral therapy (ART) regimens in infancy, HIV-1-specific antibody concentrations are associated with viral persistence and could be used to estimate the size of the residual latent reservoir on ART. This strategy could be particularly useful for screening children on suppressive ART for enrolment into therapeutic vaccine trials and other protocols aimed at achieving HIV-1 remission.
DOI of Published Version
Palma P, McManus M, Cotugno N, Rocca S, Rossi P, Luzuriaga K. The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV. Lancet HIV. 2020 May;7(5):e359-e365. doi: 10.1016/S2352-3018(20)30100-4. PMID: 32386722. Link to article on publisher's site
The lancet. HIV
Palma P, McManus MM, Cotugno N, Rocca S, Rossi P, Luzuriaga K. (2020). The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV. UMass Center for Clinical and Translational Science Supported Publications. https://doi.org/10.1016/S2352-3018(20)30100-4. Retrieved from https://escholarship.umassmed.edu/umccts_pubs/227