Title
Retromer promotes immune quiescence by suppressing Spatzle-Toll pathway in Drosophila
UMMS Affiliation
Program in Molecular Medicine
Publication Date
2014-04-01
Document Type
Article
Disciplines
Amino Acids, Peptides, and Proteins | Cellular and Molecular Physiology | Hemic and Immune Systems | Immunity | Translational Medical Research
Abstract
The Toll and Toll-like receptor signaling pathways are evolutionarily conserved pathways that regulate innate immunity in insects and mammals. While efforts have been made to clarify the signal transduction events that occur during infection, much less is known about the components that maintain immune quiescence. Here we show that retromer, an intracellular protein complex known for regulating vesicle trafficking, functions in modulating the Toll pathway in Drosophila melanogaster. In mutant animals lacking retromer function, the Toll pathway but not JAK-STAT or IMD pathway is activated, triggering both cellular and humoral responses. Genetic epistasis and clonal analysis suggest that retromer regulates a component that acts upstream of Toll. Our data further show that in the mutant the Toll ligand Spatzle has a processing pattern similar to that of after infection. Together, the results suggest a novel function of retromer in regulating Toll pathway and innate immunity at a step that modulates ligand processing or activity.
Keywords
UMCCTS funding
DOI of Published Version
10.1002/jcp.24472
Source
J Cell Physiol. 2014 Apr;229(4):512-520. doi: 10.1002/jcp.24472. Link to article on publisher's site
Journal/Book/Conference Title
Journal of cellular physiology
Related Resources
PubMed ID
24343480
Repository Citation
Zhou, Bo; Yun, Eun-Young; Ray, Lorraine; You, Jia; Ip, Y. Tony; and Lin, Xinhua, "Retromer promotes immune quiescence by suppressing Spatzle-Toll pathway in Drosophila" (2014). UMass Center for Clinical and Translational Science Supported Publications. 191.
https://escholarship.umassmed.edu/umccts_pubs/191