Multiple- vs Non- or Single-Imputation based Fuzzy Clustering for Incomplete Longitudinal Behavioral Intervention Data

UMMS Affiliation

Division of Biostatistics and Health Services Research, Department of Quantitative Health Science

Publication Date


Document Type

Conference Proceeding


Biomedical Engineering and Bioengineering | Computer Sciences | Health Information Technology | Statistics and Probability | Translational Medical Research


Disentangling patients' behavioral variations is a critical step for better understanding an intervention's effects on individual outcomes. Missing data commonly exist in longitudinal behavioral intervention studies. Multiple imputation (MI) has been well studied for missing data analyses in the statistical field, however, has not yet been scrutinized for clustering or unsupervised learning, which are important techniques for explaining the heterogeneity of treatment effects. Built upon previous work on MI fuzzy clustering, this paper theoretically, empirically and numerically demonstrate how MI-based approach can reduce the uncertainty of clustering accuracy in comparison to non-and single-imputation based clustering approach. This paper advances our understanding of the utility and strength of multiple-imputation (MI) based fuzzy clustering approach to processing incomplete longitudinal behavioral intervention data.


Fuzzy clustering, MIFuzzy, Missing values, Multiple imputation, longitudinal data, UMCCTS funding

DOI of Published Version



IEEE Int Conf Connect Health Appl Syst Eng Technol. 2016 Jun;2016:219-228. doi: 10.1109/CHASE.2016.19. Epub 2016 Aug 18. Link to article on publisher's site

Journal/Book/Conference Title

IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies

Related Resources

Link to Article in PubMed

PubMed ID