The Estimated Verbal GCS Subscore in Intubated Traumatic Brain Injury Patients: Is it Really Better
Department of Neurology; Department of Surgery; Department of Anesthesiology/Critical Care
Diagnosis | Health Services Administration | Nervous System Diseases | Neurology | Pathological Conditions, Signs and Symptoms | Translational Medical Research | Trauma
The Glasgow Coma Scale (GCS) has limited utility in intubated patients due to the inability to assign verbal subscores. The verbal subscore can be derived from the eye and motor subscores using a mathematical model, but the advantage of this method and its use in outcome prognostication in traumatic brain injury (TBI) patients remains unknown. We compared the validated "Core+CT"-IMPACT-model performance in 251 intubated TBI patients prospectively enrolled in the longitudinal OPTIMISM study between November 2009 and May 2015 when substituting the original motor GCS (mGCS) with the total estimated GCS (teGCS; with estimated verbal subscore). We hypothesized that model performance would improve with teGCS. Glasgow Outcome Scale (GOS) scores were assessed at 3 and 12 months by trained interviewers. In the complete case analysis, there was no statistically or clinically significant difference in the discrimination (C-statistic) at either time-point using the mGCS versus the teGCS (3 months: 0.893 vs. 0.871;12 months: 0.926 vs. 0.92). At 3 months, IMPACT-model calibration was excellent with mGCS and teGCS (Hosmer-Lemeshow "goodness-of-fit" chi square p value 0.9293 and 0.9934, respectively); it was adequate at 12 months with teGCS (0.5893) but low with mGCS (0.0158), possibly related to diminished power at 12 months. At both time-points, motor GCS contributed more to the variability of outcome (Nagelkerke DeltaR(2)) than teGCS (3 months: 5.8% vs. 0.4%; 12 months: 5% vs. 2.6%). The sensitivity analysis with imputed missing outcomes yielded similar results, with improved calibration for both GCS variants. In our cohort of intubated TBI patients, there was no statistically or clinically meaningful improvement in the IMPACT-model performance by substituting the original mGCS with teGCS.
Glasgow Coma Scale, estimated verbal GCS, motor GCS, outcome prognostication, traumatic brain injury, UMCCTS funding
DOI of Published Version
J Neurotrauma. 2017 Apr 15;34(8):1603-1609. doi: 10.1089/neu.2016.4657. Epub 2016 Dec 2. Link to article on publisher's site
Journal of neurotrauma
Cheng, Katarina; Bassil, Ribal; Carandang, Raphael A.; Hall, Wiley R.; and Muehlschlegel, Susanne, "The Estimated Verbal GCS Subscore in Intubated Traumatic Brain Injury Patients: Is it Really Better" (2017). UMass Center for Clinical and Translational Science Supported Publications. 176.