Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion
Department of Pathology; Program in Molecular Medicine
Allergy and Immunology | Immunity | Immunology of Infectious Disease | Immunopathology | Infectious Disease | Pathological Conditions, Signs and Symptoms | Pathology | Translational Medical Research | Virus Diseases | Viruses
Detection of unique, functionally influenza A/EBV crossreactive oligoclonal CD8 T-cell repertoires in rare individuals who remain EBV-seronegative into fourth decade of life suggests that T-cell crossreactivity dependent heterologous immunity may protect from EBV infection.
CD8, influenza, Epstein Barr virus, EBV, memory, crossreactive, heterologous immunity, UMCCTS funding
DOI of Published Version
J Allergy Clin Immunol. 2017 Oct;140(4):1206-1210. doi: 10.1016/j.jaci.2017.05.037. Epub 2017 Jun 16. Link to article on publisher's site
The Journal of allergy and clinical immunology
Watkin, Levi B.; Mishra, Rabinarayan; Gil, Anna; Aslan, Nuray; Ghersi, Dario; Luzuriaga, Katherine; and Selin, Liisa K., "Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion" (2017). UMass Center for Clinical and Translational Science Supported Publications. 171.