Title

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

UMMS Affiliation

Department of Pathology; Program in Molecular Medicine

Publication Date

2017-10

Document Type

Article

Disciplines

Allergy and Immunology | Immunity | Immunology of Infectious Disease | Immunopathology | Infectious Disease | Pathological Conditions, Signs and Symptoms | Pathology | Translational Medical Research | Virus Diseases | Viruses

Abstract

Detection of unique, functionally influenza A/EBV crossreactive oligoclonal CD8 T-cell repertoires in rare individuals who remain EBV-seronegative into fourth decade of life suggests that T-cell crossreactivity dependent heterologous immunity may protect from EBV infection.

Keywords

CD8, influenza, Epstein Barr virus, EBV, memory, crossreactive, heterologous immunity, UMCCTS funding

DOI of Published Version

10.1016/j.jaci.2017.05.037

Source

J Allergy Clin Immunol. 2017 Oct;140(4):1206-1210. doi: 10.1016/j.jaci.2017.05.037. Epub 2017 Jun 16. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of allergy and clinical immunology

Related Resources

Link to Article in PubMed

PubMed ID

28629751

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