Weight gain in early pregnancy and risk of gestational diabetes mellitus among Latinas

UMMS Affiliation

Department of Obstetrics and Gynecology; Division of Epidemiology of Chronic Diseases and Vulnerable Populations, Department of Quantitative Health Sciences

Publication Date


Document Type



Endocrinology, Diabetes, and Metabolism | Female Urogenital Diseases and Pregnancy Complications | Obstetrics and Gynecology | Translational Medical Research | Women's Health


AIM: To evaluate the association between gestational weight gain (GWG) in early pregnancy and incidence of abnormal glucose tolerance (AGT) and gestational diabetes mellitus (GDM) among Latinas.

METHODS: We conducted a retrospective cohort study of 2039 Latinas using pooled data from two medical centres in Massachusetts. Gestational weights were abstracted from medical records and GWG was categorized as low, appropriate and excessive according to 2009 Institute of Medicine Guidelines. Diagnosis of AGT and GDM was confirmed by study obstetricians.

RESULTS: A total of 143 women (7.0%) were diagnosed with GDM and 354 (17.4%) with AGT. After adjusting for age and study site, women with low GWG up to the time of GDM screen had a lower odds of GDM (OR: 0.51, 95% CI: 0.29-0.92). Among overweight women, women with excessive first-trimester GWG had 2-fold higher odds of AGT (OR: 1.96, 95% CI: 1.17-3.30) and GDM (OR: 2.07, 95% CI: 1.04-4.12) compared to those with appropriate GWG; however, these findings were not significant among normal weight or obese women.

CONCLUSION: Among Latinas, low GWG up to the time of GDM screen was associated with lower odds of AGT and GDM, while excessive GWG among overweight women was associated with higher odds. Findings highlight need for interventions in early pregnancy to help women meet GWG guidelines and to moderate GWG among overweight Latinas.


Gestational diabetes, Latina, Pregnancy, Weight gain, UMCCTS funding

DOI of Published Version



Diabetes Metab. 2019 Jan;45(1):26-31. doi: 10.1016/j.diabet.2017.10.006. Epub 2017 Nov 10. Link to article on publisher's site

Journal/Book/Conference Title

Diabetes and metabolism

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Link to Article in PubMed

PubMed ID