Title

Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo

UMMS Affiliation

Department of Dermatology

Publication Date

2019-4

Document Type

Article

Disciplines

Dermatology | Immunity | Skin and Connective Tissue Diseases | Translational Medical Research

Abstract

Tissue resident memory T cells (Trm) form in the skin in vitiligo and persist to maintain disease, as white spots often recur rapidly after discontinuing therapy. We and others have recently described melanocyte-specific autoreactive Trm in vitiligo lesions. Here, we characterize the functional relationship between Trm and recirculating memory T cells (Tcm) in our vitiligo mouse model. We found that both Trm and Tcm sensed autoantigen in the skin long after stabilization of disease, producing IFN-gamma, CXCL9, and CXCL10. Blockade of Tcm recruitment to the skin with FTY720 or depletion of Tcm with low-dose Thy1.1 antibody reversed disease, indicating that Trm cooperate with Tcm to maintain disease. Taken together, our data provide characterization of skin memory T cells in vitiligo, demonstrate that Trm and Tcm work together during disease, and indicate that targeting their survival or function may provide novel, durable treatment options for patients.

Keywords

UMCCTS funding

DOI of Published Version

10.1016/j.jid.2018.10.032

Source

J Invest Dermatol. 2019 Apr;139(4):769-778. doi: 10.1016/j.jid.2018.10.032. Epub 2018 Nov 10. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of investigative dermatology

Related Resources

Link to Article in PubMed

PubMed ID

30423329

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