Atrial fibrillation, cognition and dementia: A review
Department of Medicine, Division of Cardiovascular Medicine; Department of Neurology; Department of Psychiatry
Cardiology | Cardiovascular Diseases | Mental Disorders | Nervous System Diseases | Neurology | Pathological Conditions, Signs and Symptoms | Translational Medical Research
Atrial fibrillation (AF) is one of the most common types of cardiac arrhythmia, particularly among older adults. AF confers a 5-fold risk for thromboembolic stroke as well as a 2-fold higher risk for congestive heart failure, morbidity, and mortality. Although stroke remains an important and impactful complication of AF, recent studies have shown that AF is independently associated with other neurological disorders, including cognitive impairment and dementia, even after adjusting for prior ischemic stroke. We performed a review of the published literature on the association between AF and cognitive status. Further, we reviewed studies investigating the underlying mechanisms for this association and/or reporting the impact of AF treatment on cognitive function. While most published studies demonstrate associations between AF and impaired cognition, no AF treatment has yet been associated with a reduced incidence of cognitive decline or dementia.
UMCCTS funding, Alzheimer's disease, anticoagulants, atrial fibrillation, cognitive decline, dementia, vascular dementia
DOI of Published Version
J Cardiovasc Electrophysiol. 2017 Aug;28(8):958-965. doi: 10.1111/jce.13261. Epub 2017 Jun 21. Link to article on publisher's site
Journal of cardiovascular electrophysiology
Aldrugh, Summer; Sardana, Mayank; Henninger, Nils; Saczynski, Jane S.; and McManus, David D., "Atrial fibrillation, cognition and dementia: A review" (2017). UMass Center for Clinical and Translational Science Supported Publications. 139.