Department of Medicine; Meyers Primary Care Institute
Cancer Biology | Cellular and Molecular Physiology | Hemic and Lymphatic Diseases | Lipids | Neoplasms | Pathological Conditions, Signs and Symptoms | Translational Medical Research
Circulating saturated (SFA) and monounsaturated fatty acids (MUFA), which are predominantly derived from endogenous metabolism, may influence non-Hodgkin lymphoma (NHL) risk by modulating inflammation or lymphocyte membrane stability. However, few biomarker studies have evaluated NHL risk associated with these fats. We conducted a prospective study of 583 incident NHL cases and 583 individually matched controls with archived pre-diagnosis red blood cell (RBC) specimens in the Nurses' Health Study (NHS) and Health Professionals Follow-up Study (HPFS). RBC membrane fatty acid levels were measured using gas chromatography. Using multivariable logistic regression, we estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL and major NHL subtypes including T cell NHL (T-NHL), B cell NHL (B-NHL) and three individual B-NHLs: chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. RBC SFA and MUFA levels were not associated with NHL risk overall. However, RBC very long chain SFA levels (VLCSFA; 20:0, 22:0, 23:0) were inversely associated with B-NHLs other than CLL/SLL; ORs (95% CIs) per standard deviation (SD) increase in level were 0.81 (0.70, 0.95) for 20:0, 0.82 (0.70, 0.95) for 22:0, and 0.82 (0.70, 0.96) for 23:0 VLCSFA. Also, both VLCSFA and MUFA levels were inversely associated with T-NHL [ORs (95% CIs) per SD: VLCSFA, 0.63 (0.40, 0.99); MUFA, 0.63 (0.40, 0.99)]. The findings of inverse associations for VLCSFAs with B-NHLs other than CLL/SLL and for VLCSFA and MUFA with T-NHL suggest an influence of fatty acid metabolism on lymphomagenesis.
UMCCTS funding, de novo lipogenesis, erythrocyte, fatty acids, non-Hodgkin lymphoma
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This is the peer reviewed version of the following article: Chiu, Y. , Bertrand, K. A., Zhang, S. , Laden, F. , Epstein, M. M., Rosner, B. A., Chiuve, S. , Campos, H. , Giovannucci, E. L., Chavarro, J. E. and Birmann, B. M. (2018), A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma. Int. J. Cancer. Accepted Author Manuscript. doi:10.1002/ijc.31602, which has been published in final form at https://doi.org/10.1002/ijc.31602. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Posted with a 12-month embargo as specified at https://authorservices.wiley.com/author-resources/Journal-Authors/licensing-open-access/licensing/self-archiving.html.
DOI of Published Version
Chiu, Y. , Bertrand, K. A., Zhang, S. , Laden, F. , Epstein, M. M., Rosner, B. A., Chiuve, S. , Campos, H. , Giovannucci, E. L., Chavarro, J. E. and Birmann, B. M. (2018), A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non‐Hodgkin lymphoma. Int. J. Cancer. Accepted Author Manuscript. doi:10.1002/ijc.31602. Link to article on publisher's site
International journal of cancer
Chiu, Yu-Han; Bertrand, Kimberly A.; Zhang, Shumin; Laden, Francine; Epstein, Mara M.; Rosner, Bernard A.; Chiuve, Stephanie; Campos, Hannia; Giovannucci, Edward L.; Chavarro, Jorge E.; and Birmann, Brenda M., "A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma" (2018). UMass Center for Clinical and Translational Science Supported Publications. 136.
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