Statin use and risk of multiple myeloma: An analysis from the Cancer Research Network

UMMS Affiliation

Meyers Primary Care Institute; Department of Medicine, Division of Geriatric Medicine

Publication Date


Document Type



Neoplasms | Public Health | Translational Medical Research


Animal and human data suggest statins may be protective against developing multiple myeloma; however, findings may be biased by the interrelationship with lipid levels. We investigated the association between statin use and risk of multiple myeloma in a large US population, with an emphasis on accounting for this potential bias. We conducted a case-control study nested within 6 US integrated healthcare systems participating in the National Cancer Institute-funded Cancer Research Network. Adults aged >/=40 years who were diagnosed with multiple myeloma from 1998-2008 were identified through cancer registries (N=2532). For each case, 5 controls were matched on age, sex, health plan, and membership duration prior to diagnosis/index date. Statin prescriptions were ascertained from electronic pharmacy records. To address potential biases related to lipid levels and medication prescribing practices, multivariable marginal structural models were used to model statin use (>/=6 cumulative months) and risk of multiple, with examination of multiple latency periods. Statin use 48-72 months prior to diagnosis/index date was associated with a suggestive 20-28% reduced risk of developing multiple myeloma, compared to non-users. Recent initiation of statins was not associated with myeloma risk (risk ratio range 0.90-0.99 with 0-36 months latency). Older patients had more consistent protective associations across all latency periods (risk ratio range 0.67-0.87). Our results suggest that the association between statin use and multiple myeloma risk may vary by exposure window and age. Future research is warranted to investigate the timing of statin use in relation to myeloma diagnosis.


UMCCTS funding

DOI of Published Version



Int J Cancer. 2017 May 15. doi: 10.1002/ijc.30745. Link to article on publisher's site

Journal/Book/Conference Title

International journal of cancer

Related Resources

Link to Article in PubMed

PubMed ID