The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partners, UMass Memorial Health Care and Baystate Medical Center. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. Other key partners include our patients and communities, foundations, biotechnology and pharmaceutical companies, and members of the venture capital and philanthropic communities. Our goals are to accelerate basic discoveries and develop and support the next generation in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.

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Publications from 2019

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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling, Luca D'Agostino, Yingchao Nie, Qi Li, Y. Tony Ip, and Nan Gao

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Gamification to Motivate the Unmotivated Smoker: The "Take a Break" Digital Health Intervention, Amanda C. Blok, Rajani S. Sadasivam, Daniel J. Amante, Ariana Kamberi, Julie Flahive, Jeanne Morley, Joseph Conigliaro, and Thomas K. Houston

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Clinical predictors of adverse cardiovascular events for acute pediatric drug exposures, Stephanie Carreiro, Simone Miller, Bo Wang, Paul Wax, Sharan Campleman, Alex F. Manini, and ACMT Toxicology Investigators Consortium (ToxIC)

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Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila, Yingchao Nie, Shiyan Yu, Qi Li, Niraj K. Nirala, Alla Amcheslavsky, Yvonne J. K. Edwards, Patrick W. Shum, Zhong Jiang, Wei Wang, Biliang Zhang, Nan Gao, and Y. Tony Ip

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Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany DeSouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, and Silvia Corvera

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis, Matthew S. Harkey, Julie E. Davis, Bing Lu, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Timothy E. McAlindon, and Jeffrey B. Driban

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Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients, Christina L. Clarke, Lawrence H. Kushi, Jessica Chubak, Pamala A. Pawloski, Joanna E. Bulkley, Mara M. Epstein, Andrea N. Burnett-Hartman, Bethan Powell, Celeste L. Pearce, and Heather Spencer Feigelson

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses, Aniuska Becerra Artiles, John Cruz, John D. Leszyk, John Sidney, Alessandro Sette, Scott A. Shaffer, and Lawrence J. Stern

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling, Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, and Wen Xue

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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Resident Memory and Recirculating Memory T Cells Cooperate to Maintain Disease in a Mouse Model of Vitiligo, Jillian M. Richmond, James P. Strassner, Medhi Rashighi, Priti Agarwal, Madhuri Garg, Kingsley I. Essien, Lila S. Pell, and John E. Harris

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Age-and-sex stratified prevalence of atrial fibrillation in rural Western India: Results of SMART-India, a population-based screening study, Apurv Soni, Sunil Karna, Nisha Fahey, Saket Sanghai, Harshil Patel, Shyamsundar Raithatha, Sunil Thanvi, Somashekhar Nimbalkar, Ben Freedman, Jeroan J. Allison, and David D. McManus

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Trends in cause of death among patients with multiple myeloma in Puerto Rico and the United States SEER population, 1987-2013, Maira Castaneda-Avila, Karen J. Ortiz-Ortiz, Carlos R. Torres-Cintron, Brenda M. Birmann, and Mara M. Epstein

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Come from away: Best practices in mini-sabbaticals for the development of young investigators: a White Paper by the SEQUIN (mini-Sabbatical Evaluation and QUality ImprovemeNt) Group, Michael H. Pillinger, Stephenie C. Lemon, Martin S. Zand, P. Jeffrey Foster Jr., Jeanne S. Merchant, Robert Kimberly, Jeroan J. Allison, Bruce N. Cronstein, Claudia Galeano, Jeanne Holden-Wiltse, Melissa Trayhan, Robert J. White, Amanda Davin, and Kenneth G. Saag

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A Machine Learning-based Approach for Collaborative Non-Adherence Detection during Opioid Abuse Surveillance using a Wearable Biosensor, Rohitpal Singh, Brittany Lewis, Brittany Chapman, Stephanie Carreiro, and Krishna Venkatasubramanian

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DEBrowser: interactive differential expression analysis and visualization tool for count data, Alper Kucukural, Onur Yukselen, Deniz M. Ozata, Melissa J. Moore, and Manuel Garber

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The influence of payor status on outcomes associated with surgical repair of upper gastrointestinal perforations due to peptic ulcer disease in the United States, Vijaya Daniel, M. Didem Ayturk, Doyle V. Ward, Beth A. McCormick, and Heena P. Santry

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Weight gain in early pregnancy and risk of gestational diabetes mellitus among Latinas, Tiffany A. Moore Simas, Molly E. Waring, Katherine Callaghan, Katherine Leung, M. Ward Harvey, Anna BuAbbud, and Lisa Chasan-Taber

Publications from 2018

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Dabigatran Versus Rivaroxaban for Secondary Stroke Prevention in Patients with Atrial Fibrillation Rehabilitated in Skilled Nursing Facilities, Matthew Alcusky, Anne L. Hume, Marc Fisher, Jennifer Tjia, Robert J. Goldberg, David D. McManus, and Kate L. Lapane

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Magnitude and impact of multiple chronic conditions with advancing age in older adults hospitalized with acute myocardial infarction, Mayra Tisminetzky, Hoa L. Nguyen, Jerry H. Gurwitz, David D. McManus, Joel M. Gore, Sonal Singh, Jorge L. Yarzebski, and Robert J. Goldberg

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Sex-differences in post-discharge outcomes among patients hospitalized for atrial fibrillation, Bindu Kalesan, Amartya Kundu, Aditya Vaze, Elizabeth Pino, Allan J. Walkey, Ramachandran S. Vasan, and David D. McManus

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Twenty-five year trends (1986-2011) in hospital incidence and case-fatality rates of ventricular tachycardia and ventricular fibrillation complicating acute myocardial infarction, Hoang V. Tran, Arlene S. Ash, Joel M. Gore, Chad E. Darling, Catarina I. Kiefe, and Robert J. Goldberg

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Online health information seeking by adults hospitalized for acute coronary syndromes: Who looks for information, and who discusses it with healthcare providers, Molly E. Waring, David D. McManus, Daniel J. Amante, Chad E. Darling, and Catarina I. Kiefe

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MicroRNA-96 Promotes Schistosomiasis Hepatic Fibrosis in Mice by Suppressing Smad7, Xufeng Luo, Dongmei Zhang, Jun Xie, Qin Su, Xing He, Ruipu Bai, Guangping Gao, and Weiqing Pan

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Extracellular vesicles in oral squamous carcinoma carry oncogenic miRNA profile and reprogram monocytes via NF-kappaB pathway, Fatemeh Momen-Heravi and Shashi Bala

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Barriers to Healthcare Access and to Improvements in Health-Related Quality of Life After an Acute Coronary Syndrome (From TRACE-CORE), Nathaniel A. K. Erskine, Barbara L. Gandek, Hoang V. Tran, Hawa Ozien Abu, David D. McManus, Catarina I. Kiefe, and Robert J. Goldberg

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Faculty member writing groups support productivity, Peter R. Chai, Stephanie Carreiro, Jennifer L. Carey, Katherine L. Boyle, Brittany Chapman, and Edward W. Boyer

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Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy, Margaret M. McManus, Jennifer L. Henderson, Anita Gautam, Robin M. Brody, Eric R. Weiss, Deborah Persaud, Eric O. Mick, Katherine Luzuriaga, and PACTG 356 Investigators

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Inflammasome-derived cytokine IL18 suppresses amyloid-induced seizures in Alzheimer-prone mice, TeChen Tzeng, Yuto Hasegawa, Risa Iguchi, Amy Cheung, Daniel R. Caffrey, Elizabeth Jeanne Thatcher, Wenjie Mao, Gail Germain, Nelsy DePaula Tamburro, Shigeo Okabe, Michael T. Heneka, Eicke Latz, Kensuke Futai, and Douglas T. Golenbock

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A Community-Based Pilot Survey of Pediatric Food Allergies in a Maryland Orthodox Jewish Community, Peter A. Kahn, Michelle K. Trivedi, Amira A. Ramadan, William J. Sheehan, Carter R. Petty, and Wanda Phipatanakul

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Objective measurement of physical activity outcomes in lifestyle interventions among adults: A systematic review, Valerie J. Silfee, Christina Haughton, Danielle E. Jake-Schoffman, Andrea Lopez-Cepero, Christine N. May, Meera Sreedhara, Milagros C. Rosal, and Stephenie C. Lemon

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Pregnant and Postpartum Women With Bipolar Disorder: Taking the Care to Where They Are, Amritha Bhat, Joseph M. Cerimele, and Nancy Byatt

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Geographic Variation in the Initiation of Commonly Used Opioids and Dosage Strength in United States Nursing Homes, Jacob N. Hunnicutt, Jonggyu Baek, Matthew Alcusky, Anne L. Hume, Shao-Hsien Liu, Christine M. Ulbricht, Jennifer Tjia, and Kate L. Lapane

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Massachusetts Child Psychiatry Access Program for Moms: Utilization and Quality Assessment, Nancy Byatt, John Straus, Arielle Stopa, Kathleen Biebel, Leena Mittal, and Tiffany A. Moore Simas

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Barriers to Healthcare Access and Long-Term Survival After an Acute Coronary Syndrome, Nathaniel A. K. Erskine, Molly E. Waring, David D. McManus, Darleen M. Lessard, Catarina I. Kiefe, and Robert J. Goldberg

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A Qualitative Analysis of Patients' Perceptions of Shared Decision Making in the Emergency Department: "Let Me Know I Have a Choice", Elizabeth M. Schoenfeld, Sarah L. Goff, Gwendolyn Downs, Robert J. Wenger, Peter K. Lindenauer, and Kathleen M. Mazor

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Pre-diagnosis plasma immune markers and risk of non-Hodgkin lymphoma in two prospective cohort studies, Mara M. Epstein, Bernard Rosner, Elizabeth C. Breen, Julie L. Batista, Edward L. Giovannucci, Larry Magpantay, Jon C. Aster, Scott J. Rodig, Kimberly A. Bertrand, Francine Laden, Otoniel Martinez-Maza, and Brenda M. Birmann

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Is perception of excessive weight gain in a woman's last pregnancy associated with less weight gain in her current pregnancy?, Kasey M. Hebert, Tiffany A. Moore Simas, Noreen C. Okwara, and Molly E. Waring

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Screening mammography among nursing home residents in the United States: Current guidelines and practice, Deborah Mack, Mara M. Epstein, Catherine E. Dube, Robin E. Clark, and Kate L. Lapane

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Post-Acute Care Setting, Facility Characteristics, and Post-Stroke Outcomes: A Systematic Review, Matthew Alcusky, Christine M. Ulbricht, and Kate L. Lapane

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mHealth for the Detection and Intervention in Adolescent and Young Adult Substance Use Disorder, Stephanie Carreiro, Peter R. Chai, Jennifer L. Carey, David A. Smelson, and Edward W. Boyer

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An Enhanced Visualization Method to Aid Behavioral Trajectory Pattern Recognition Infrastructure for Big Longitudinal Data, Hua (Julia) Fang and Zhaoyang Zhang

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A prospective analysis of circulating saturated and monounsaturated fatty acids and risk of non-Hodgkin lymphoma, Yu-Han Chiu, Kimberly A. Bertrand, Shumin Zhang, Francine Laden, Mara M. Epstein, Bernard A. Rosner, Stephanie Chiuve, Hannia Campos, Edward L. Giovannucci, Jorge E. Chavarro, and Brenda M. Birmann

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth, Qi Li, Niraj K. Nirala, Yingchao Nie, Hsi-Ju Chen, Gary R. Ostroff, Junhao Mao, Qi Wang, Lan Xu, and Y. Tony Ip

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Non-Hispanic Black-White disparities in pain and pain management among newly admitted nursing home residents with cancer, Deborah Mack, Jacob N. Hunnicutt, William M. Jesdale, and Kate L. Lapane

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Caste matters: perceived discrimination among women in rural India, Jasmine A. Khubchandani, Apurv Soni, Nisha Fahey, Nitin Raithatha, Anusha Prabhakaran, Nancy Byatt, Tiffany A. Moore Simas, Ajay Phatak, Milagros C. Rosal, Somashekhar Nimbalkar, and Jeroan J. Allison

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Preventing Opioid Use Disorders among Fishing Industry Workers, Angela Walter, Cesar Morocho, Lauren King, John Bartlett, Debra Kelsey, Monica DeSousa, Gretchen Biesecker, and Laura Punnett

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Adherence to 20 Emergency General Surgery Best Practices: Results of a National Survey, Angela M. Ingraham, M. Didem Ayturk, Catarina I. Kiefe, and Heena P. Santry

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Comparative Analysis of Immune Cells Reveals a Conserved Regulatory Lexicon, Elisa Donnard, Pranitha Vangala, Shaked Afik, Sean M. McCauley, Anetta Nowosielska, Alper Kucukural, Barbara Tabak, Xiaopeng Zhu, William E. Diehl, Patrick McDonel, Nir Yosef, Jeremy Luban, and Manuel Garber

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Should We Use the IMPACT-Model for the Outcome Prognostication of TBI Patients? A Qualitative Study Assessing Physicians' Perceptions, Jesse Moskowitz, Thomas Quinn, Muhammad W. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

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A Systematic Review of Integrated Care Interventions Addressing Perinatal Depression Care in Ambulatory Obstetric Care Settings, Tiffany A. Moore Simas, Michael Flynn, Aimee R. Kroll-Desrosiers, Stephanie M. Carvalho, Len L. Levin, Kathleen Biebel, and Nancy Byatt

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How obstetric settings can help address gaps in psychiatric care for pregnant and postpartum women with bipolar disorder, Nancy Byatt, Lucille Cox, Tiffany A. Moore Simas, Nisha Kini, Kathleen Biebel, Padma Sankaran, Holly A. Swartz, and Linda Weinreb

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Access to Pharmacotherapy Amongst Women with Bipolar Disorder during Pregnancy: a Preliminary Study, Nancy Byatt, Lucille Cox, Tiffany A. Moore Simas, Kathleen Biebel, Padma Sankaran, Holly A. Swartz, and Linda Weinreb

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eFCM: An Enhanced Fuzzy C-Means Algorithm for Longitudinal Intervention Data, Venkata Sukumar Gurugubelli, Zhouzhou Li, Honggang Wang, and Hua (Julia) Fang

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Optimized Cholesterol-siRNA Chemistry Improves Productive Loading onto Extracellular Vesicles, Reka A. Haraszti, Rachael Miller, Marie C. Didiot, Annabelle Biscans, Julia F. Alterman, Matthew R. Hassler, Loic Roux, Dimas Echeverria, Ellen Sapp, Marian DiFiglia, Neil Aronin, and Anastasia Khvorova

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"Don't lose hope early": Hemorrhagic diffuse axonal injury on head computed tomography is not associated with poor outcome in moderate to severe traumatic brain injury patients, Nils Henninger, Rebecca A. Compton, Muhammad W. Khan, Raphael A. Carandang, Wiley R. Hall, and Susanne Muehlschlegel

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Relation of Orthostatic Hypotension With New-Onset Atrial Fibrillation (From the Framingham Heart Study), Darae Ko, Sarah R. Preis, Steven A. Lubitz, David D. McManus, Ramachandran S. Vasan, Naomi M. Hamburg, Emelia J. Benjamin, and Gary F. Mitchell

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Cognitive Impairment and Pain Among Nursing Home Residents With Cancer, Catherine E. Dube, Deborah Mack, Jacob N. Hunnicutt, and Kate L. Lapane

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Alcohol and Drug Use among Deaf and Hard-of-Hearing Individuals: A Secondary Analysis of NHANES 2013-2014, Melissa L. Anderson, Bei-Hung Chang, and Nisha Kini

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Disparities in access to emergency general surgery care in the United States, Jasmine A. Khubchandani, Connie Shen, M. Didem Ayturk, Catarina I. Kiefe, and Heena P. Santry

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Does provider advice to increase physical activity differ by activity level among US adults with cardiovascular disease risk factors?, Meera Sreedhara, Valerie J. Silfee, Milagros C. Rosal, Molly E. Waring, and Stephenie C. Lemon

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Gendered Race Modification of the Association Between Chronic Stress and Depression Among Black and White U.S. Adults, Ganga Bey, Molly E. Waring, William M. Jesdale, and Sharina D. Person

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Feasibility and Acceptability of Delivering a Postpartum Weight Loss Intervention via Facebook: A Pilot Study, Molly E. Waring, Tiffany A. Moore Simas, Jessica L. Oleski, Rui Sherry Xiao, Julie A. Mulcahy, Christine N. May, and Sherry L. Pagoto

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Wearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach, Keerthi Kumar. Chintha, Premananda Indic, Brittany Chapman, Edward W. Boyer, and Stephanie Carreiro

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Feasibility and Acceptability of Mindfulness for Survivors of Homicide and Their Providers, Stephanie W. Hartwell, Jeroan J. Allison, Bonita Jones, Rachel Rodrigues, Clementina Chery, Julianna Andrews, and Carl E. Fulwiler

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Atrial fibrillation is associated with anterior predominant white matter lesions in patients presenting with embolic stroke, Yunis M. Mayasi, Johanna Helenius, David D. McManus, Richard P. Goddeau Jr, Adalia H. Jun-O'Connell, Majaz Moonis, and Nils Henninger

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Post-hospitalization Treatment Regimen and Readmission for C. difficile Colitis in Medicare Beneficiaries, Charles M. Psoinos, Courtney E. Collins, M. Didem Ayturk, Frederick A. Anderson Jr., and Heena P. Santry

Publications from 2017

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Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme, Apurv Soni, Nisha Fahey, Shyamsundar Raithatha, Anna Handorf, John Bostrom, Ravi Shah, Robert J. Goldberg, Jeroan J. Allison, and David D. McManus

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Change in Cognitive Function in the Month After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transition, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education), Jane S. Saczynski, David D. McManus, Molly E. Waring, Darleen M. Lessard, Milena D. Anatchkova, Jerry H. Gurwitz, Jeroan J. Allison, Arlene S. Ash, Richard H. McManus, David C. Parish, Robert J. Goldberg, and Catarina I. Kiefe

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Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires, Nuray Aslan, Levi B. Watkin, Anna Gil, Rabinarayan Mishra, Fransenio G. Clark, Raymond M. Welsh, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Oxycodone Ingestion Patterns in Acute Fracture Pain With Digital Pills, Peter R. Chai, Stephanie Carreiro, Brendan J. Innes, Brittany Chapman, Kristin L. Schreiber, Robert R. Edwards, Adam W. Carrico, and Edward W. Boyer

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Treatment Effectiveness in Heart Failure with Comorbidity: Lung Disease and Kidney Disease, Jerry H. Gurwitz, David J. Magid, David H. Smith, Grace H. Tabada, Sue Hee. Sung, Larry A. Allen, David D. McManus, Robert J. Goldberg, Mayra Tisminetzky, and Alan S. Go

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Gender and Age Differences in Levels, Types and Locations of Physical Activity among Older Adults Living in Car-Dependent Neighborhoods, Wenjun Li, Elizabeth Procter-Gray, Linda C. Churchill, Scott E. Crouter, Kevin J. Kane, Jie Tian, Patricia D. Franklin, Judith K. Ockene, and Jerry H. Gurwitz

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Racial Differences in Eating Patterns and Food Purchasing Behaviors Among Urban Older Women, Wenjun Li, Gretchen A. Youssef, Elizabeth Procter-Gray, Barbara C. Olendzki, Tasha Cornish, Rashelle B. Hayes, Linda C. Churchill, Kevin J. Kane, Kristen Brown, and Michelle F. Magee

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Lifelong estradiol exposure and risk of depressive symptoms during the transition to menopause and postmenopause, Wendy K. Marsh, Joyce T. Bromberger, Sybil L. Crawford, Katherine Leung, Howard M. Kravitz, John F. Randolph, Hadine Joffe, and Claudio N. Soares

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Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma, Cliff I. Oduor, Yasin Kaymaz, Kiprotich Chelimo, Juliana A. Otieno, John Michael Ong'echa, Ann M. Moormann, and Jeffrey A. Bailey

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PRogram In Support of Moms (PRISM): a pilot group randomized controlled trial of two approaches to improving depression among perinatal women, Nancy Byatt, Tiffany A. Moore Simas, Kathleen Biebel, Padma Sankaran, Lori Pbert, Linda Weinreb, Douglas M. Ziedonis, and Jeroan J. Allison

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Neighborhood Socioeconomic Status Predicts Health After Hospitalization for Acute Coronary Syndromes: Findings From TRACE-CORE (Transitions, Risks, and Actions in Coronary Events-Center for Outcomes Research and Education), Lisa Nobel, William M. Jesdale, Jennifer Tjia, Molly E. Waring, David C. Parish, Arlene S. Ash, Catarina I. Kiefe, and Jeroan J. Allison

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Geographic Diffusion and Implementation of Acute Care Surgery: An Uneven Solution to the National Emergency General Surgery Crisis, Jasmine A. Khubchandani, Angela M. Ingraham, Vijaya Daniel, M. Didem Ayturk, Catarina I. Kiefe, and Heena Santry

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Mobility limitations and fear of falling in non-English speaking older Mexican-Americans, Eric G. James, Phillip Conatser, Murat Karabulut, Suzanne G. Leveille, Jeffrey M. Hausdorff, Sarah Cote, Katherine L. Tucker, Bruce A. Barton, Jonathan F. Bean, Soham Al Snih, and Kyriakos S. Markides

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What Families Need and Physicians Deliver: Contrasting Communication Preferences Between Surrogate Decision-Makers and Physicians During Outcome Prognostication in Critically Ill TBI Patients, Thomas Quinn, Jesse Moskowitz, Muhammad A. Khan, Lori Shutter, Robert J. Goldberg, Nananda Col, Kathleen M. Mazor, and Susanne Muehlschlegel

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Outpatient beta-blockers and survival from sepsis: Results from a national cohort of Medicare beneficiaries, Kathleen E. Singer, Courtney E. Collins, Julie Flahive, Allison Wyman, M. Didem Ayturk, and Heena Santry

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Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion, Levi B. Watkin, Rabinarayan Mishra, Anna Gil, Nuray Aslan, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope, Brian G. Pierce, Elisabeth N. Boucher, Kurt H. Piepenbrink, Ejemel Monir, Chelsea A. Rapp, William D. Thomas Jr., Eric J. Sundberg, Zhiping Weng, and Yan Wang

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Prevalence of Long-Term Opioid Use in Long-Stay Nursing Home Residents, Jacob N. Hunnicutt, Stavroula A. Chrysanthopoulou, Christine M. Ulbricht, Anne L. Hume, Jennifer Tjia, and Kate L. Lapane

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The Impact of Nondifferential Exposure Misclassification on the Performance of Propensity Scores for Continuous and Binary Outcomes: A Simulation Study, Mollie E. Wood, Stavroula A. Chrysanthopoulou, Hedvig M. E. Nordeng, and Kate L. Lapane

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Pediatric Obstructive Sleep Apnea in High-Risk Populations: Clinical Implications, Mai K. Elmallah, Evan Bailey, Michelle Trivedi, Ted M. Kremer, and Lawrence M. Rhein

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Clinical and Echocardiographic Correlates of Left Atrial Function Index: The Framingham Offspring Study, Mayank Sardana, Adedotun Ogunsua, Aditya Vaze, Gerard P. Aurigemma, David D. McManus, and Nisha I. Parikh

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Pediatric Obstructive Sleep Apnea and Asthma: Clinical Implications, Michelle Trivedi, Mai K. Elmallah, Evan Bailey, Ted M. Kremer, and Lawrence M. Rhein

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High pathogen burden in childhood promotes the development of unconventional innate-like CD8+ T cells, Yves T. Falanga, Michela Frascoli, Yasin Kaymaz, Catherine Forconi, John Michael Ong'echa, Jeffrey A. Bailey, Leslie J. Berg, and Ann M. Moormann

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Atrial fibrillation, cognition and dementia: A review, Summer Aldrugh, Mayank Sardana, Nils Henninger, Jane S. Saczynski, and David D. McManus

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A survey of practices for the use of electronic health records to support research recruitment, Jihad S. Obeid, Laura M. Beskow, Marie Rape, Ramkiran Gouripeddi, R. Anthony Black, James J. Cimino, Peter J. Embi, Chunhua Weng, Rebecca Marnocha, John B. Buse, and Methods and Process and Informatics Domain Task Force Workgroup

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Acculturation, Depression, and Smoking Cessation: a trajectory pattern recognition approach, Sun S. Kim, Hua (Julia) Fang, Kunsook Bernstein, Zhaoyang Zhang, Joseph R. DiFranza, Douglas Ziedonis, and Jeroan J. Allison

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The association of dietary quality with colorectal cancer among normal weight, overweight and obese men and women: a prospective longitudinal study in the USA, Rosalie A. Torres Stone, Molly E. Waring, Sarah L. Cutrona, Catarina I. Kiefe, Jeroan J. Allison, and Chyke A. Doubeni

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Predictors of mortality in the elderly after open repair for perforated peptic ulcer disease, Vijaya Daniel, Jason T. Wiseman, Julie Flahive, and Heena Santry

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Implementing a Fee-for-Service Cervical Cancer Screening and Treatment Program in Cameroon: Challenges and Opportunities, Geneva A. DeGregorio, Simon Manga, Edith Kiyang, Florence Manjuh, Leslie Bradford, Preetam Cholli, Richard Wamai, Rebecca Kemunto Ogembo, Zacharie Sando, Yuxin Liu, Lisa Kennedy Sheldon, Kathleen Nulah, Thomas Welty, Edith Welty, and Javier Gordon Ogembo

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Racial Differences in Misclassification of Healthy Eating Based on Food Frequency Questionnaire and 24-Hour Dietary Recalls, Barbara C. Olendzki, Elizabeth Procter-Gray, M. F. Magee, Gretchen A. Youssef, Kevin J. Kane, Linda C. Churchill, Judith K. Ockene, and Wenjun Li

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Music as an Adjunct to Opioid-Based Analgesia, Peter R. Chai, Stephanie Carreiro, Megan L. Ranney, Ketki Karanam, Marko Ahtisaari, Robert Edwards, Kristin L. Schreiber, Lubabah Ben-Ghaly, Timothy B. Erickson, and Edward W. Boyer