The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partners, UMass Memorial Health Care and Baystate Medical Center. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. Other key partners include our patients and communities, foundations, biotechnology and pharmaceutical companies, and members of the venture capital and philanthropic communities. Our goals are to accelerate basic discoveries and develop and support the next generation in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.

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Publications from 2021

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Development of the Practice Readiness to Evaluate and address Perinatal Depression (PREPD) assessment, Grace A. Masters, Linda Brenckle, Padma Sankaran, Tiffany Moore Simas, Sharina D. Person, Jeroan J. Allison, Douglas Ziedonis, Jean Ko, Cheryl Robbins, and Nancy Byatt

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Demonstrating an approach for evaluating synthetic geospatial and temporal epidemiologic data utility: Results from analyzing >1.8 million SARS-CoV-2 tests in the United States National COVID Cohort Collaborative (N3C) [preprint], Jason A. Thomas, Randi E. Foraker, Noa Zamstein, Philip R.O. Payne, and Adam B. Wilcox

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Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative, Tellen D. Bennett, Christopher G. Chute, Uma Maheswara Reddy Vangala, Katherine Luzuriaga, and National COVID Cohort Collaborative (N3C) Consortium

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Outcomes of SARS-CoV-2 Infection in Patients with Chronic Liver Disease and Cirrhosis: a N3C Study [preprint], Jin Ge, Mark J. Pletcher, Jennifer C. Lai, and N3C Consortium

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Outcomes of COVID-19 in Patients With Cancer: Report From the National COVID Cohort Collaborative (N3C), Noha Sharafeldin, Benjamin Bates, Qianqian Song, Vithal Madhira, Yao Yan, Sharlene Dong, Eileen Lee, Nathaniel Kuhrt, Yu Raymond Shao, Feifan Liu, Timothy Bergquist, Justin Guinney, Jing Su, and Umit Topaloglu

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Primary care physician perspectives on screening for axial spondyloarthritis: A qualitative study, Kate L. Lapane, Divya Shridharmurthy, Sara Khan, Daniel Lindstrom, Ariel Beccia, Esther Yi, Jonathan Kay, Catherine E. Dube, and Shao-Hsien Liu

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The RADx Tech Clinical Studies Core: A Model for Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, and David D. McManus

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The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, and David D. McManus

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Barriers and Facilitators to Implementation of Value-Based Care Models in New Medicaid Accountable Care Organizations in Massachusetts: A Study Protocol, Sarah L. Goff, Deborah Gurewich, Matthew J. Alcusky, Aparna Kachoria, Joanne Nicholson, and Jay S. Himmelstein

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Peripartum depression: Does risk versus diagnostic status impact mother-infant bonding and perceived social support, Megan M. Hare, Aimee Kroll-Desrosiers, and Kristina M. Deligiannidis

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Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information [preprint], Halie M. Rando, Feifan Liu, and Melissa A. Haendel

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Longitudinal assessment of diagnostic test performance over the course of acute SARS-CoV-2 infection [preprint], Rebecca L. Smith, Laura L. Gibson, Alyssa N. Owens, John P. Broach, Bruce A. Barton, Peter Lazar, David D. McManus, and Christopher B. Brooke

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National Trends in Statin Use among the United States Nursing Home Population (2011-2016), Deborah Mack, Anne L. Hume, Jennifer Tjia, and Kate L. Lapane

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Adapting a Traumatic Brain Injury Goals-of-Care Decision Aid for Critically Ill Patients to Intracerebral Hemorrhage and Hemispheric Acute Ischemic Stroke, Kelsey Goostrey, Christopher Lee, Kelsey Jones, Thomas Quinn, Jesse Moskowitz, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, Kathleen M. Mazor, David Y. Hwang, and Susanne Muehlschlegel

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Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis, Pasquale Piccolo, Florie Borel, Christian Mueller, and Nicola Brunetti-Pierri

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Development and psychometric evaluation of the Social Connectedness Index in nursing home residents with Alzheimer's disease and dementia using the Minimum Data Set 3.0, Carol A. Bova, William M. Jesdale, Attah Mbrah, Lynn Botelho, and Kate L. Lapane

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The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction [preprint], Tellen D. Bennett, Christopher G. Chute, and N3C Consortium

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Health Care Satisfaction in Relation to Gender Identity: Behavioral Risk Factor Surveillance Survey, 20 States (2014-2018), Katarina A. Ferrucci, Tubanji Walubita, Ariel L. Beccia, Eric Y. Ding, William M. Jesdale, Kate L. Lapane, and Carl G. Streed Jr.

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Impact of Patient Access to Online VA Notes on Healthcare Utilization and Clinician Documentation: a Retrospective Cohort Study, Amanda C. Blok, Daniel J. Amante, Timothy P. Hogan, Rajani S. Sadasivam, Stephanie L. Shimada, Susan Woods, Kim M. Nazi, and Thomas K. Houston

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The relationship between restless sleep and symptoms of the knee: data from the Osteoarthritis Initiative, Kate L. Lapane, Divya Shridharmurthy, Matthew S. Harkey, Jeffrey B. Driban, Catherine E. Dube, and Shao-Hsien Liu

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Geographic Variation in Anticoagulant Use and Resident, Nursing Home, and County Characteristics Associated With Treatment Among US Nursing Home Residents, Matthew Alcusky, Jonggyu Baek, Jennifer Tjia, David D. McManus, and Kate L. Lapane

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Creating the Capacity to Screen Deaf Women for Perinatal Depression: A Pilot Study, Melissa L. Anderson, Kelly S. Wolf Craig, Sheri Hostovsky, Maureen Bligh, Emily Bramande, Kristin Walker, Kathleen Biebel, and Nancy Byatt

Publications from 2020

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Rigor and reproducibility training for first year medical students in research pathways, Kate L. Lapane and Catherine E. Dube

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Statin Discontinuation and Life-Limiting Illness in Non-Skilled Stay Nursing Homes at Admission, Deborah S. Mack, Jonggyu Baek, Jennifer Tjia, and Kate L. Lapane

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Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions, Milka Koupenova-Zamor and Jane E. Freedman

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New Opportunities and Cautionary Insights about Decentralizing and Deglobalizing Clinical Trials During the Great Lockdown, Denise Dunlap, Roberto S. Santos, David D. McManus, Bryan O. Buchholz, Nathaniel S. Hafer, and MaryAnn Picard

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English language proficiency, complete tooth loss, and recent dental visits among older adults in the United States, Andriana M. Foiles Sifuentes, Maira A. Castaneda-Avila, and Kate L. Lapane

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Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case-control study, Andres V. Ardisson Korat, Yu-Han Chiu, Kimberly A. Bertrand, Shumin Zhang, Mara M. Epstein, Bernard A. Rosner, Stephanie Chiuve, Hannia Campos, Edward L. Giovannucci, Jorge E. Chavarro, and Brenda M. Birmann

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The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study, Laura S. Chiu, Alison Pedley, Joseph M. Massaro, Emelia J. Benjamin, Gary F. Mitchell, David D. McManus, Jayashri Aragam, Ramachandran S. Vasan, Susan Cheng, and Michelle T. Long

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Association of Use of an Integrated Specialty Pharmacy With Total Medical Expenditures Among Members of an Accountable Care Organization, Apurv Soni, Brian S. Smith, Thomas Scornavacca, Bill McElnea, Alice Shakman, Eric W. Dickson, and David D. McManus

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Prostate-specific antigen testing after the US Preventive Services Task Force recommendation: a population-based analysis of electronic health data, Daniel M. Frendl, Mara M. Epstein, Hassan Fouayzi, Richard Krajenta, Benjamin A. Rybicki, and Mitchell H. Sokoloff

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Racial/Ethnic Differences in Staff-Assessed Pain Behaviors Among Newly Admitted Nursing Home Residents, Reynolds A. Morrison, William M. Jesdale, Catherine E. Dube, Sarah N. Forrester, Anthony P. Nunes, Carol A. Bova, and Kate L. Lapane

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An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes, Nathan D. Lawson, Rui Li, Masahiro Shin, Ann S. Grosse, Onur Yukselen, Oliver A. Stone, Alper Kucukural, and Lihua Julie Zhu

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Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study, Aditya Vaze, Khanh-Van T. Tran, Kahraman Tanriverdi, Mayank Sardana, Darleen M. Lessard, J. Kevin Donahue, Bruce A. Barton, Gerard P. Aurigemma, Amiya Mandapati, Jane E. Freedman, and David D. McManus

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Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma, Yasin Kaymaz, Cliff I. Oduor, Ozkan Aydemir, Micah A. Luftig, Juliana A. Otieno, John Michael. Ong'echa, Jeffrey A. Bailey, and Ann M. Moormann

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The relationship of aging, complete tooth loss, and having a dental visit in the last 12 months, Andriana M. Foiles Sifuentes, Maira Castaneda-Avila, and Kate L. Lapane

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Outside Our Walls: the Case for City-Wide Collaboration to Reduce Disparities, Jennifer S. Haas, Stephenie C. Lemon, Karen M. Freund, Tracy A. Battaglia, and Translating Research Into Practice (TRIP) Consortium Writing Group

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Does Home Remedy Use Contribute to Medication Nonadherence Among Blacks with Hypertension, Yendelela L. Cuffee, Milagros C. Rosal, J. Lee Hargraves, Becky A. Briesacher, Suzanne Akuley, Noof Altwatban, Sandral Hullett, and Jeroan J. Allison

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Quantitative HIV-1-specific antibodies as predictors of peripheral blood cell-associated HIV-1 DNA concentrations, Margaret M. McManus, Brad Karalius, Kunjal Patel, Deborah Persaud, Katherine Luzuriaga, and Pediatric HIV/AIDS Cohort Study

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Goals-of-care decision aid for critically ill patients with TBI: Development and feasibility testing, Susanne Muehlschlegel, David Y. Hwang, Julie M. Flahive, Thomas Quinn, Christopher Lee, Jesse Moskowitz, Kelsey Goostrey, Kelsey Jones, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, and Kathleen M. Mazor

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The 'Take a Break' game: Randomized trial protocol for a technology-assisted brief abstinence experience designed to engage lower-motivated smokers., Daniel J. Amante, Amanda C. Blok, Catherine S. Nagawa, Jessica G. Wijesundara, Jeroan J. Allison, Sharina D. Person, Jeanne Morley, Joseph Conigliaro, Kristin M. Mattocks, Lawrence D. Garber, Thomas K. Houston, and Rajani S. Sadasivam

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Advances in Understanding the Causes and Consequences of Health Disparities in Aging Minorities, Sarah N. Forrester, Janiece L. Taylor, Keith E. Whitfield, and Roland J. Thorpe Jr.

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Patient-specific reference values for objective physical function tests: data from the Osteoarthritis Initiative, Matthew S. Harkey, Lori Lyn Price, Kieran F. Reid, Grace H. Lo, Shao-Hsien Liu, Kate L. Lapane, Lucas Ogura Dantas, Timothy E. McAlindon, and Jeffrey B. Driban

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Composite quantitative knee structure metrics predict the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative, Matthew S. Harkey, Julie E. Davis, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Bing Lu, Timothy E. McAlindon, and Jeffrey B. Driban

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A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation, Jung-Min Kim, Yeon-Suk Yang, Xianpeng Ge, Matthew B. Greenblatt, and Jae-Hyuck Shim

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The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV, Paolo Palma, Margaret M. McManus, Nicola Cotugno, Salvatore Rocca, Paolo Rossi, and Katherine Luzuriaga

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Bioinformatics Core Survey Highlights the Challenges Facing Data Analysis Facilities, Julie A. Dragon, Chris Gates, Shannan Ho Sui, John N. Hutchinson, R. Krishna Murthy Karuturi, Alper Kucukural, Shawn Polson, Alberto Riva, Matthew Lee Settles, Jyothi Thimmapuram, and Stuart S. Levine

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DolphinNext: a distributed data processing platform for high throughput genomics, Onur Yukselen, Osman Turkyilmaz, Ahmet R. Ozturk, Manuel Garber, and Alper Kucukural

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Translating research into practice: Protocol for a community-engaged, stepped wedge randomized trial to reduce disparities in breast cancer treatment through a regional patient navigation collaborative, Tracy A. Battaglia, Karen M. Freund, Jennifer S. Haas, Nicole Casanova, Sharon Bak, Howard Cabral, Rachel A. Freedman, Karen Burns. White, and Stephenie C. Lemon

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A cardiovascular disease risk prediction algorithm for use with the Medicare current beneficiary survey, Hassan Fouayzi, Arlene S. Ash, and Amy K. Rosen

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Understanding Naloxone Uptake from an Emergency Department Distribution Program Using a Low-Energy Bluetooth Real-time Location System, Jeffrey T. Lai, Brittany P. Chapman, Stephanie P. Carreiro, Kavita M. Babu, Edward W. Boyer, and Peter R. Chai

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A REDCap-based model for electronic consent (eConsent): Moving toward a more personalized consent, Colleen E. Lawrence, German Chiriboga, Karin V. Goins, Melissa A. Fischer, Jeroan J. Allison, Stephenie C. Lemon, and Paul A. Harris

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Diagnostic Category Prevalence in 3 Classification Systems Across the Transition to the International Classification of Diseases, Tenth Revision, Clinical Modification, Randall P. Ellis, Heather E. Hsu, Chenlu Song, Tzu-Chun Kuo, Bruno Martins, Jeffrey J. Siracuse, Ying Liu, and Arlene S. Ash

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Feasibility of a pilot, randomized controlled trial using a personalized health monitoring device with pregnant women for behavioral sleep research, Mary T. Paterno, Favorite Iradukunda, and Marquis Hawkins

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Genomic Characterization of Endothelial Enhancers Reveals a Multifunctional Role for NR2F2 in Regulation of Arteriovenous Gene Expression, Samir Sissaoui, Jun Yu, Aimin Yan, Rui Li, Onur Yukselen, Alper Kucukural, Lihua Julie Zhu, and Nathan D. Lawson

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Cancer Pain in Relation to Metropolitan Area Segregation and Nursing Home Racial and Ethnic Composition, William M. Jesdale, Deborah Mack, Sarah N. Forrester, and Kate L. Lapane

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Changes in Glycemic Load Are Positively Associated with Small Changes in Primary Stress Markers of Allostatic Load in Puerto Rican Women, Andrea Lopez-Cepero, Milagros C. Rosal, Christine F. Frisard, Sharina D. Person, Ira S. Ockene, and Katherine L. Tucker

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Epstein-Barr Virus Epitope-Major Histocompatibility Complex Interaction Combined with Convergent Recombination Drives Selection of Diverse T Cell Receptor alpha and beta Repertoires, Anna Gil, Larisa Kamga, Ramakanth Chirravuri-Venkata, Nuray Aslan, Fransenio G. Clark, Dario Ghersi, Katherine Luzuriaga, and Liisa K. Selin

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Clinical predictors of adverse cardiovascular events for acute pediatric drug exposures, Stephanie Carreiro, Simone Miller, Bo Wang, Paul Wax, Sharan Campleman, Alex F. Manini, and ACMT Toxicology Investigators Consortium (ToxIC)

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Utilization of Health Care Among Perinatal Women in the United States: The Role of Depression, Grace A. Masters, Nien-Chen Li, Kate L. Lapane, Shao-Hsien Liu, Sharina D. Person, and Nancy Byatt

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Prevalent Statin Use in Long-Stay Nursing Home Residents with Life-Limiting Illness, Deborah S. Mack, Jennifer Tjia, Anne L. Hume, and Kate L. Lapane

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Are We Optimizing the Use of Dual Antiplatelet Therapy in Patients Hospitalized with Acute Myocardial Infarction?, Essa Hariri, Darleen M. Lessard, Joel M. Gore, Jeffrey J. Rade, and Robert J. Goldberg

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Reducing Hospitalizations and Emergency Department Visits in Patients With Venous Thromboembolism Using a Multicomponent Care Transition Intervention, Alok Kapoor, Sarah Bloomstone, Saud Javed, Abiramy Maheswaran, Ahmed Nagy, Rasha Elhag, Diana Houng, Chad E. Darling, David D. McManus, Bruce A. Barton, and Kathleen M. Mazor

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Identifying monoclonal gammopathy of undetermined significance in electronic health data, Mara M. Epstein, Cassandra Saphirak, Yanhua Zhou, Candace LeBlanc, Alan G. Rosmarin, Arlene S. Ash, Sonal Singh, Kimberly A. Fisher, Brenda M. Birmann, and Jerry H. Gurwitz

Publications from 2019

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Sensitive detection of EBV microRNAs across cancer spectrum reveals association with decreased survival in adult acute myelocytic leukemia, Mercedeh J. Movassagh, Cliff Oduor, Catherine Forconi, Ann M. Moormann, and Jeffrey A. Bailey

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Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling, Alec Gramann, Arvind M. Venkatesan, Melissa Guerin, and Craig J. Ceol

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Alignment of stakeholder agendas to facilitate the adoption of school-supervised asthma therapy, Michelle Trivedi, Janki Patel, Shushmita Hoque, Raphael Mizrahi, Kathleen Biebel, Wanda Phipatanakul, Stephenie C. Lemon, Nancy Byatt, Lynn B. Gerald, Milagros C. Rosal, and Lori Pbert

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Upper Gastrointestinal Perforations: A Possible Danger of Antibiotic Overuse, Vijaya Daniel, Stephanie Francalancia, Nili S. Amir, M. Didem Ayturk, Stacy B. Sanders, Jonathan R. Wisler, Courtney E. Collins, Doyle V. Ward, Catarina I. Kiefe, Beth A. McCormick, and Heena P. Santry

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Standardized activities for lay patient navigators in breast cancer care: Recommendations from a citywide implementation study, Karen M. Freund, Jennifer S. Haas, Stephenie C. Lemon, Karen Burns White, Nicole Casanova, Laura S. Dominici, John K. Erban, Rachel A. Freedman, Ted A. James, Naomi Y. Ko, Amy M. LeClair, Beverly Moy, Susan K. Parsons, and Tracy A. Battaglia

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Healthy Eating Policy Strategies in Community Health Improvement Plans: A Cross-Sectional Survey of US Local Health Departments, Meera Sreedhara, Karin V. Goins, Christine F. Frisard, Milagros C. Rosal, and Stephenie C. Lemon

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Circulating microRNA Profiles in Acetaminophen Toxicity, Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, and Victor R. Ambros

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The Misshapen subfamily of Ste20 kinases regulate proliferation in the aging mammalian intestinal epithelium, Qi Li, Niraj K. Nirala, Hsi-Ju Chen, Yingchao Nie, Wei Wang, Biliang Zhang, Michael P. Czech, Qi Wang, Lan Xu, Junhao Mao, and Y. Tony Ip

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CDR3alpha drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection, Larisa Kamga, Anna Gil, InYoung Song, Robin M. Brody, Dario Ghersi, Nuray Aslan, Lawrence J. Stern, Liisa K. Selin, and Katherine Luzuriaga

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Association between food insecurity and emotional eating in Latinos and the mediating role of perceived stress, Andrea Lopez-Cepero, Christine F. Frisard, Ganga Bey, Stephenie C. Lemon, and Milagros C. Rosal

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Positive screening rates for bipolar disorder in pregnant and postpartum women and associated risk factors, Grace A. Masters, Linda Brenckle, Padma Sankaran, Sharina D. Person, Jeroan J. Allison, Tiffany A. Moore Simas, Jean Y. Ko, Cheryl L. Robbins, Wendy K. Marsh, and Nancy Byatt

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Measuring quality and outcomes of research collaborations: An integrative review, Beth B. Tigges, Doriane Miller, Katherine M. Dudding, Joyce E. Balls-Berry, Elaine A. Borawski, Gaurav Dave, Nathaniel Hafer, Kim S. Kimminau, Rhonda G. Kost, Kimberly Littlefield, Jackilen Shannon, and Usha Menon

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Nurse-Driven mHealth Implementation Using the Technology Inpatient Program for Smokers (TIPS): Mixed Methods Study, Amanda C. Blok, Rajani S. Sadasivam, Timothy P. Hogan, Angela Patterson, Nicole Day, and Thomas K. Houston

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Estimated stroke risk, yield, and number needed to screen for atrial fibrillation detected through single time screening: a multicountry patient-level meta-analysis of 141,220 screened individuals, Nicole Lowres, David D. McManus, and Apurv Soni

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Point-of-care technologies in heart, lung, blood and sleep disorders from the Center for Advancing Point-of-Care Technologies, Eric Y. Ding, Emily Ensom, Nathaniel Hafer, Bryan Buchholz, Mary Ann Picard, Denise Dunlap, Eugene Rogers, Carl Lawton, Ainat Koren, Craig M. Lilly, Timothy P. Fitzgibbons, and David D. McManus

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Clinical Molecular Marker Testing Data Capture to Promote Precision Medicine Research Within the Cancer Research Network, Andrea N. Burnett-Hartman and Mara M. Epstein

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Diverse repertoire of human adipocyte subtypes develops from transcriptionally distinct mesenchymal progenitor cells, So Yun Min, Anand Desai, Zinger Yang, Agastya Sharma, Tiffany DeSouza, Ryan Genga, Alper Kucukural, Lawrence M. Lifshitz, Soren Nielsen, Camilla Scheele, Rene Maehr, Manuel Garber, and Silvia Corvera

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Potential uses of naltrexone in emergency department patients with opioid use disorder, Evan S. Bradley, David Liss, Stephanie P. Carreiro, David Eric Brush, and Kavita M. Babu

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Stepping Up Active Transportation in Community Health Improvement Plans: Findings From a National Probability Survey of Local Health Departments, Meera Sreedhara, Karin V. Goins, Christine F. Frisard, Milagros C. Rosal, and Stephenie C. Lemon

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Design, analysis, power, and sample size calculation for three-phase interrupted time series analysis in evaluation of health policy interventions, Bo Zhang, Wei Liu, Stephenie C. Lemon, Bruce A. Barton, Melissa A. Fischer, Colleen Lawrence, Elizabeth J. Rahn, Maria I. Danila, Kenneth G. Saag, Paul A. Harris, and Jeroan J. Allison

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Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling, Luca D'Agostino, Yingchao Nie, Qi Li, Y. Tony Ip, and Nan Gao

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Naturally processed HLA-DR3-restricted HHV-6B peptides are recognized broadly with polyfunctional and cytotoxic CD4 T-cell responses, Aniuska Becerra Artiles, John Cruz, John D. Leszyk, John Sidney, Alessandro Sette, Scott A. Shaffer, and Lawrence J. Stern

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Gamification to Motivate the Unmotivated Smoker: The "Take a Break" Digital Health Intervention, Amanda C. Blok, Rajani S. Sadasivam, Daniel J. Amante, Ariana Kamberi, Julie Flahive, Jeanne Morley, Joseph Conigliaro, and Thomas K. Houston

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Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila, Yingchao Nie, Shiyan Yu, Qi Li, Niraj K. Nirala, Alla Amcheslavsky, Yvonne J. K. Edwards, Patrick W. Shum, Zhong Jiang, Wei Wang, Biliang Zhang, Nan Gao, and Y. Tony Ip

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Psychosocial factors associated with treatment outcomes in women with obesity and major depressive disorder who received behavioral activation for depression, Daniel Kern, Andrew Busch, Kristin L. Schneider, Steven A. Miller, Bradley M. Appelhans, Molly E. Waring, Matthew C. Whited, and Sherry L. Pagoto

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Generation of Functional Human Adipose Tissue in Mice from Primed Progenitor Cells, Raziel Rojas-Rodriguez, Jorge Lujan-Hernandez, So Yun Min, Tiffany DeSouza, Patrick Teebagy, Anand Desai, Heather Tessier, Robert Slamin, Leah Siegel-Reamer, Cara Berg, Angel Baez, Janice F. Lalikos, and Silvia Corvera

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Racial Segregation Across U.S. Nursing Homes: A Systematic Review of Measurement and Outcomes, Deborah Mack, William M. Jesdale, Christine M. Ulbricht, Sarah N. Forrester, Pryce S. Michener, and Kate L. Lapane

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Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition, Reka A. Haraszti, Rachael Miller, Michelle L. Dubuke, Andrew H. Coles, Marie C. Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere, John D. Leszyk, Julia F. Alterman, Bruno M. D. C. Godinho, Matthew R. Hassler, Rachel Wollacott, Yan Wang, Scott A. Shaffer, Neil Aronin, and Anastasia Khvorova

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Early pre-radiographic structural pathology precedes the onset of accelerated knee osteoarthritis, Matthew S. Harkey, Julie E. Davis, Bing Lu, Lori Lyn Price, Robert J. Ward, James W. MacKay, Charles B. Eaton, Grace H. Lo, Mary F. Barbe, Ming Zhang, Jincheng Pang, Alina C. Stout, Timothy E. McAlindon, and Jeffrey B. Driban

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Accuracy and Usability of a Novel Algorithm for Detection of Irregular Pulse Using a Smartwatch Among Older Adults: Observational Study, Eric Y. Ding, Dong Han, Cody Whitcomb, Syed Khairul Bashar, Oluwaseun Adaramola, Apurv Soni, Jane Saczynski, Timothy P. Fitzgibbons, Majaz Moonis, Steven A. Lubitz, Darleen M. Lessard, Mellanie True Hills, Bruce A. Barton, Ki Chon, and David D. McManus

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Changes in Anticoagulant Utilization Among United States Nursing Home Residents With Atrial Fibrillation From 2011 to 2016, Matthew Alcusky, David D. McManus, Anne L. Hume, Marc Fisher, Jennifer Tjia, and Kate L. Lapane

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Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients, Christina L. Clarke, Lawrence H. Kushi, Jessica Chubak, Pamala A. Pawloski, Joanna E. Bulkley, Mara M. Epstein, Andrea N. Burnett-Hartman, Bethan Powell, Celeste L. Pearce, and Heather Spencer Feigelson

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Quantitative Human Immunodeficiency Virus (HIV)-1 Antibodies Correlate With Plasma HIV-1 RNA and Cell-associated DNA Levels in Children on Antiretroviral Therapy, Margaret M. McManus, Jennifer L. Henderson, Anita Gautam, Robin M. Brody, Eric R. Weiss, Deborah Persaud, Eric O. Mick, Katherine Luzuriaga, and PACTG 356 Investigators

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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling, Haiwei Mou, Deniz M. Ozata, Jordan L. Smith, Ankur Sheel, Suet-Yan Kwan, Soren Hough, Alper Kucukural, Zachary Kennedy, Yueying Cao, and Wen Xue

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Precise therapeutic gene correction by a simple nuclease-induced double-stranded break, Sukanya Iyer, Sneha Suresh, Dongsheng Guo, Katelyn Daman, Jennifer C. J. Chen, Pengpeng Liu, Marina Zieger, Kevin Luk, Benjamin P. Roscoe, Christian Mueller, Oliver D. King, Charles P. Emerson Jr., and Scot A. Wolfe

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Association between allostatic load and health behaviours: a latent class approach, Sarah N. Forrester, Jeannie-Marie Leoutsakos, Joseph J. Gallo, Roland J. Thorpe Jr, and Teresa E. Seeman