The University of Massachusetts Center for Clinical and Translational Science (UMCCTS) was founded in 2006 to enhance clinical and translational research across the five University of Massachusetts campuses (Amherst, Boston, Dartmouth, Lowell, UMass Medical School) and our clinical partners, UMass Memorial Health Care and Baystate Medical Center. With the receipt of an NIH Clinical and Translational Science Award (CTSA) in 2010, and its successful renewal in 2015, the UMCCTS joined a network of 62 NIH-funded centers collaborating to transform the conduct of clinical and translational research across the U.S. Other key partners include our patients and communities, foundations, biotechnology and pharmaceutical companies, and members of the venture capital and philanthropic communities. Our goals are to accelerate basic discoveries and develop and support the next generation in clinical and translational research. This collection showcases publications that are the result of UMCCTS supported research.

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Publications from 2022

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Design and Preliminary Findings of Adherence to the Self-Testing for Our Protection From COVID-19 (STOP COVID-19) Risk-Based Testing Protocol: Prospective Digital Study, Carly Herbert, John P. Broach, Ben S. Gerber, Nisha Fahey, Elizabeth Aaker Orvek, Peter Lazar, Julia M. Ferranto, Kamran Noorishirazi, Shivakumar Valpady, Qiming Shi, Honghuang Lin, Kathryn Marvel, Laura L. Gibson, Bruce A. Barton, Stephenie C. Lemon, Nathaniel S. Hafer, David D. McManus, and Apurv Soni

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Novel Framework for Measuring Whole Knee Osteoarthritis Progression Using Magnetic Resonance Imaging, Jeffrey B. Driban, Lori Lyn Price, Michael P. LaValley, Grace H. Lo, Ming Zhang, Matthew S. Harkey, Amanda Canavatchel, and Timothy E. McAlindon

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Association of trends in child undernutrition and implementation of the National Rural Health Mission in India: A nationally representative serial cross-sectional study on data from 1992 to 2015, Apurv Soni, Nisha Fahey, Zulfiqar Bhutta, Wenjun Li, Tiffany A. Moore Simas, Somashekhar Nimbalkar, and Jeroan J. Allison

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Risk and Outcome of Breakthrough COVID-19 Infections in Vaccinated Patients With Cancer: Real-World Evidence From the National COVID Cohort Collaborative, Qianqian Song, Benjamin Bates, Yu Raymond Shao, Fang-Chi Hsu, Feifan Liu, Vithal Madhira, Amit Kumar Mitra, Timothy Bergquist, Ramakanth Kavuluru, Xiaochun Li, Noha Sharafeldin, Jing Su, and Umit Topaloglu

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Comparison of Rapid Antigen Tests' Performance between Delta (B.1.61.7; AY.X) and Omicron (B.1.1.529; BA1) Variants of SARS-CoV-2: Secondary Analysis from a Serial Home Self-Testing Study [preprint], Apurv Soni, Carly Herbert, Andreas Filippaios, John P. Broach, Andres Colubri, Nisha Fahey, Kelsey Woods, Janvi Nanavati, Colton Wright, Taylor Orwig, Karen Gilliam, Honghuang Lin, Laurel O'Connor, Caitlin Pretz, M. Didem Ayturk, Elizabeth Aaker Orvek, Julie M. Flahive, Peter Lazar, Qiming Shi, Laura L. Gibson, Pamela Stamegna, Nathaniel S. Hafer, Katherine Luzuriaga, Bruce A. Barton, David D. McManus, and RADx Clinical Studies Core team and Test Us At Home Investigators

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Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses, Long Chi Nguyen, Dongbo Yang, Vlad Nicolaescu, Thomas J. Best, Glenn Randall, Marsha Rich Rosner, and National COVID Cohort Collaborative Consortium

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Glycemic Control and Clinical Outcomes in U.S. Patients With COVID-19: Data From the National COVID Cohort Collaborative (N3C) Database, Rachel Wong, Margaret Hall, Rohith Vaddavalli, Adit Anand, Neha Arora, Carolyn T. Bramante, Victor Garcia, Steven Johnson, Mary Saltz, Jena S. Tronieri, Yun Jae Yoo, John B. Buse, Joel Saltz, Joshua Miller, Richard Moffitt, and N3C Consortium

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Variability of Prognostic Communication in Critically Ill Neurologic Patients: A Pilot Multicenter Mixed-Methods Study, Connie Ge, Adeline L. Goss, Sybil L. Crawford, Kelsey Goostrey, Praewpannarai Buddadhumaruk, Anne-Marie Shields, Catherine L. Hough, Bernard Lo, Shannon S. Carson, Jay Steingrub, Douglas B. White, and Susanne Muehlschlegel

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Understanding Healthcare Professionals' Perspectives on Point-of-Care Testing, Sean Teebagy, Zi-Yue Wang, Denise Dunlap, Connor Saleeba, Danielle DiMezza, JoAnn Crain, Craig M. Lilly, Bryan Buchholz, David D. McManus, and Nathaniel S. Hafer

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Imaging Net Retrograde Axonal Transport In Vivo: A Physiological Biomarker, Pin-Tsun Justin Lee, Zachary C. Kennedy, Yuzhen Wang, Yimeng Lu, Carolina Cefaliello, Ozgun Uyan, Chun-Qing Song, Bruno M. D. C. Godinho, Zuoshang Xu, Mary Rusckowski, Wen Xue, and Robert H. Brown Jr.

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Caregiver-perceived neighborhood safety and pediatric asthma severity: 2017-2018 National Survey of Children's Health, Shushmita Hoque, Melissa Goulding, Max D. Hazeltine, Katarina A. Ferrucci, Michelle K. Trivedi, and Shao-Hsien Liu

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Association of Social Determinants of Health With Adherence to Second-generation Antipsychotics for People With Bipolar Disorders in a Medicaid Population, Nien-Chen Li, Matthew J. Alcusky, Grace A. Masters, and Arlene S. Ash

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Characteristics, Outcomes, and Severity Risk Factors Associated With SARS-CoV-2 Infection Among Children in the US National COVID Cohort Collaborative, Blake Martin

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Association Between COVID-19 and Mortality in Hip Fracture Surgery in the National COVID Cohort Collaborative (N3C): A Retrospective Cohort Study, Eli B. Levitt, David A. Patch, Scott Mabry, Alfredo Terrero, Byron Jaeger, Melissa A. Haendel, Christopher G. Chute, Jonathan H. Quade, Brent Ponce, Steven Theiss, Clay A. Spitler, and Joey P. Johnson

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Association between Residential Segregation and Long-Term Acute Care Hospital Performance on Improvement in Function among Ventilated Patients, Snigdha Jain, Allan J. Walkey, Anica C. Law, Lauren E. Ferrante, Peter K. Lindenauer, and Harlan M. Krumholz

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Examination of the Allostatic Load Construct and Its Longitudinal Association With Health Outcomes in the Boston Puerto Rican Health Study, Andrea Lopez-Cepero, Amanda C. McClain, Milagros C. Rosal, Katherine L. Tucker, and Josiemer Mattei

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Sex and organ-specific risk of major adverse renal or cardiac events in solid organ transplant recipients with COVID-19, Amanda J. Vinson, Ran Dai, Gaurav Agarwal, Alfred J. Anzalone, Stephen B. Lee, Evan French, Amy L. Olex, Vithal Madhira, Roslyn B. Mannon, and National COVID Cohort Collaborative (N3C) Consortium

Publications from 2021

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SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant, Mario Meza-Segura, James R. Birtley, Ana Maldonado-Contreras, Christian Mueller, Karl J. Simin, Lawrence J. Stern, and Beth A. McCormick

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Dataset from: COVID-19: A Gray Swan’s Impact on the Adoption of Novel Medical Technologies, Denise Dunlap, Roberto S. Santos, Craig M. Lilly, Sean Teebagy, Nathaniel S. Hafer, Bryan O. Buchholz, and David D. McManus

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UMMS CTSA homepage, UMass Center for Clinical and Translational Science

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Modeling human T1D-associated autoimmune processes, Mohsen Khosravi-Maharlooei, Rachel Madley, Chiara Borsotti, Leonardo M. R. Ferreira, Robert C. Sharp, Michael A. Brehm, Dale L. Greiner, Audrey V. Parent, Mark S. Anderson, Megan Sykes, and Remi J. Creusot

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Increased risk of psychiatric sequelae of COVID-19 is highest early in the clinical course [preprint], Ben Coleman, Elena Casiraghi, Hannah Blau, Lauren Chan, Melissa Haendel, Bryan Laraway, Tiffany J. Callahan, Rachel R. Deer, Ken Wilkins, Justin Reese, and Peter N. Robinson

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Sex-Specific Associations between Cartilage Structure and Metabolism at Rest and Acutely Following Walking and Drop-Landing, Matthew S. Harkey, J. Troy Blackburn, Anthony C. Hackney, Michael D. Lewek, Randy J. Schmitz, and Brian Pietrosimone

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Risk factors associated with suicidal ideation in newly admitted working-age nursing home residents, Julie Hugunin, Yiyang Yuan, Anthony J. Rothschild, Kate L. Lapane, and Christine M. Ulbricht

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The Preliminary Efficacy of a Sleep Self-management Intervention Using a Personalized Health Monitoring Device during Pregnancy, Wei-Hsin Hsiao, Mary T. Paterno, Favorite Iradukunda, and Marquis Hawkins

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An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis, Batuhan Yenilmez, Nicole Wetoska, Mark Kelly, Dimas Echeverria, Kyounghee Min, Lawrence M. Lifshitz, Julia F. Alterman, Matthew R. Hassler, Samuel R. Hildebrand, Chloe DiMarzio, Nicholas McHugh, Lorenc Vangjeli, Jacquelyn Sousa, Michael A. Brehm, Anastasia Khvorova, and Michael P. Czech

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Synergies between centralized and federated approaches to data quality: a report from the national COVID cohort collaborative, Emily R. Pfaff and National COVID Cohort Collaborative (N3C) Consortium

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Developing Signs of Safety: A Deaf-accessible counselling toolkit for trauma and addiction, Melissa L. Anderson, Neil S. Glickman, Kelly S. Wolf Craig, Amanda K. Sortwell Crane, Alexander M. Wilkins, and Lisa M. Najavits

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Outcomes of SARS-CoV-2 Infection in Patients With Chronic Liver Disease and Cirrhosis: A National COVID Cohort Collaborative Study, Jin Ge, Mark J. Pletcher, Jennifer C. Lai, and N3C Consortium

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Ultradeep HIV-1 Proviral Envelope Sequencing Reveals Complex Population Structure within and between Brain and Splenic Tissues, Rebecca Rose, Maria Paz Gonzalez-Perez, David J. Nolan, Sissy Cross, Susanna L. Lamers, and Katherine Luzuriaga

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Perspectives on barriers and facilitators to mental health support after a traumatic birth among a sample of primarily White and privately insured patients, Wanlu (LuLu) Xu, Esther Boama-Nyarko, Grace A. Masters, Tiffany A. Moore Simas, Christine M. Ulbricht, and Nancy Byatt

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Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data, Xueying Yang, Jing Sun, Rena C. Patel, Jiajia Zhang, Siyuan Guo, Qulu Zheng, Amy L. Olex, Bankole Olatosi, Sharon B. Weissman, Jessica Y. Islam, Christopher G. Chute, Melissa Haendel, Gregory D. Kirk, Xiaoming Li, and National COVID Cohort Collaborative Consortium

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Trends in SARS-CoV-2 seroprevalence in Massachusetts estimated from newborn screening specimens [preprint], Kevin C. Ma, Jaime E. Hale, Yonatan H. Grad, Galit Alter, Katherine Luzuriaga, Roger B. Eaton, Stephanie Fischinger, Devinder Kaur, Robin M. Brody, Sameed M. Siddiqui, Dylan Leach, Catherine M. Brown, R. Monina Klevens, Lawrence Madoff, and Anne Marie Comeau

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Early childhood undernutrition, preadolescent physical growth, and cognitive achievement in India: A population-based cohort study, Apurv Soni, Nisha Fahey, Zulfiqar A. Bhutta, Wenjun Li, Jean A. Frazier, Tiffany A. Moore Simas, Somashekhar M. Nimbalkar, and Jeroan J. Allison

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Who has long-COVID? A big data approach [preprint], Emily R. Pfaff, Andrew T. Girvin, Tellen D. Bennett, Abhishek Bhatia, Ian M. Brooks, Rachel R. Deer, Jonathan P. Dekermanjian, Sarah Elizabeth Jolley, Michael G. Kahn, Kristin Kostka, Julie A. McMurry, Richard Moffitt, Anita Walden, Christopher G. Chute, Melissa A. Haendel, and The N3C Consortium

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Secondary Precipitants of Atrial Fibrillation and Anticoagulation Therapy, Darae Ko, Connor Saleeba, Hammad Sadiq, Sybil L. Crawford, Tenes Paul, Qiming Shi, Zi-Yue Wang, Emelia J. Benjamin, Allan J. Walkey, Steven A. Lubitz, Alok Kapoor, and David D. McManus

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Hinfp is a guardian of the somatic genome by repressing transposable elements, Niraj K. Nirala, Qi Li, Prachi N. Ghule, Hsi-Ju Chen, Rui Li, Lihua Julie Zhu, Ruijia Wang, Nicholas P. Rice, Junhao Mao, Janet L. Stein, Gary S. Stein, Andre J. van Wijnen, and Y. Tony Ip

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Prognostic Uncertainty in Critically Ill Patients with Traumatic Brain Injury: A Multicenter Qualitative Study, Kelsey Jones, Thomas Quinn, Kathleen M. Mazor, and Susanne Muehlschlegel

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Differences in Blood Pressure Levels Among Children by Sociodemographic Status, Melissa Goulding, Robert J. Goldberg, and Stephenie C. Lemon

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scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in Treg function, Kyle Gellatly, James P. Strassner, Kingsley I. Essien, Maggi Ahmed Refat, Rachel L. Murphy, Anthony Coffin-Schmitt, Michael L. Frisoli, Xueli Fan, Evangeline E. Kim, Zainab Abbas, Patrick McDonel, Manuel Garber, and John E. Harris

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Longitudinal analysis of SARS-CoV-2 vaccine breakthrough infections reveal limited infectious virus shedding and restricted tissue distribution [preprint], Ruian Ke, Alyssa N. Owens, John Broach, Bruce A. Barton, Peter Lazar, David D. McManus, and Christopher B. Brooke

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Differences in survival among multiple myeloma patients in the United States SEER population by neighborhood socioeconomic status and race/ethnicity, Maira A. Castaneda-Avila, William M. Jesdale, Ariel L. Beccia, Ganga S. Bey, and Mara M. Epstein

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Knowledge of Breastfeeding and Kangaroo Mother Care Practices Among General Practitioners in Rural Western India, Nisha Fahey, Nitesh Sadhwani, Smit Shethwala, Jeroan J. Allison, Apurv Soni, and Somashekhar Nimbalkar

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Methodological Challenges for Epidemiologic Studies of Deprescribing at the End of Life, Jennifer Tjia, Jennifer L. Lund, Deborah Mack, Attah Mbrah, Yiyang Yuan, Qiaoxi Chen, Seun Osundolire, and Cara L. McDermott

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Incorporating systems-level stakeholder perspectives into the clinical trial design of school-supervised asthma therapy, Michelle Trivedi, Shushmita Hoque, Janki Luther, Michelle Spano, Holly Shillan, Hallie Pearl, Hannah L. Seay, Wanda Phipatanakul, Lynn B. Gerald, and Lori Pbert

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Sugar-Sweetened Beverage Consumption and Sleep Duration and Quality Among Pregnant Women, Monica L. Wang, Brooke A. Libby, Tiffany A. Moore Simas, and Molly E. Waring

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Allele-specific knockdown of mutant HTT protein via editing at coding region SNP heterozygosities, Sarah Oikemus, Edith L. Pfister, Ellen Sapp, Kathryn O. Chase, Lori A. Kennington, Edward Hudgens, Rachael Miller, Lihua Julie Zhu, Akanksh Chaudhary, Eric O. Mick, Miguel Sena-Esteves, Scot A. Wolfe, Marian DiFiglia, Neil Aronin, and Michael H. Brodsky

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BMP Signaling Promotes Neural Crest Identity and Accelerates Melanoma Onset, Alec K. Gramann, William Tyler Frantz, Karen A. Dresser, Camilla Borges Ferreira Gomes, Christine G. Lian, April C. Deng, and Craig J. Ceol

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Development of the Practice Readiness to Evaluate and address Perinatal Depression (PREPD) assessment, Grace A. Masters, Linda Brenckle, Padma Sankaran, Tiffany Moore Simas, Sharina D. Person, Jeroan J. Allison, Douglas Ziedonis, Jean Ko, Cheryl Robbins, and Nancy Byatt

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SARS-CoV-2 Initiates Programmed Cell Death in Platelets, Milka Koupenova-Zamor, Heather A. Corkrey, Olga Vitseva, Kahraman Tanriverdi, Mohan Somasundaran, Ping Liu, Shaukat Soofi, Krishna M. Parsi, Alyssa Cousineau, Rene Maehr, Jennifer P. Wang, Jeffrey J. Rade, and Robert W. Finberg

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Demonstrating an approach for evaluating synthetic geospatial and temporal epidemiologic data utility: Results from analyzing >1.8 million SARS-CoV-2 tests in the United States National COVID Cohort Collaborative (N3C) [preprint], Jason A. Thomas, Randi E. Foraker, Noa Zamstein, Philip R.O. Payne, and Adam B. Wilcox

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Clinical Characterization and Prediction of Clinical Severity of SARS-CoV-2 Infection Among US Adults Using Data From the US National COVID Cohort Collaborative, Tellen D. Bennett, Christopher G. Chute, Uma Maheswara Reddy Vangala, Katherine Luzuriaga, and National COVID Cohort Collaborative (N3C) Consortium

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Validation of an electronic algorithm for Hodgkin and non-Hodgkin lymphoma in ICD-10-CM, Mara M. Epstein, Cassandra Saphirak, Christopher Delude, Jerry H. Gurwitz, and Susan E. Andrade

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Association Between Glucagon-Like Peptide 1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Use and COVID-19 Outcomes, Anna R. Kahkoska, Trine Julie Abrahamsen, G. Caleb Alexander, Tellen D. Bennett, Christopher G. Chute, Melissa A. Haendel, Klara R. Klein, Hemalkumar Mehta, Joshua D. Miller, Richard A. Moffitt, Til Sturmer, Kajsa Kvist, John B. Buse, and N3C Consortium

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Outcomes of SARS-CoV-2 Infection in Patients with Chronic Liver Disease and Cirrhosis: a N3C Study [preprint], Jin Ge, Mark J. Pletcher, Jennifer C. Lai, and N3C Consortium

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Outcomes of COVID-19 in Patients With Cancer: Report From the National COVID Cohort Collaborative (N3C), Noha Sharafeldin, Benjamin Bates, Qianqian Song, Vithal Madhira, Yao Yan, Sharlene Dong, Eileen Lee, Nathaniel Kuhrt, Yu Raymond Shao, Feifan Liu, Timothy Bergquist, Justin Guinney, Jing Su, and Umit Topaloglu

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Primary care physician perspectives on screening for axial spondyloarthritis: A qualitative study, Kate L. Lapane, Divya Shridharmurthy, Sara Khan, Daniel Lindstrom, Ariel Beccia, Esther Yi, Jonathan Kay, Catherine E. Dube, and Shao-Hsien Liu

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Geographic Variation of Statin Use Among US Nursing Home Residents With Life-limiting Illness, Deborah Mack, Jonggyu Baek, Jennifer Tjia, and Kate L. Lapane

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The RADx Tech Clinical Studies Core: A Model for Academic Based Clinical Studies, Laura L. Gibson, Nisha M. Fahey, Nathaniel Hafer, John P. Broach, Bruce A. Barton, Stephenie C. Lemon, Allison Blodgett, and David D. McManus

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The RADx Tech Test Verification Core and the ACME POCT in the Evaluation of COVID-19 Testing Devices: A Model for Progress and Change, Eric J. Nehl, Karl J. Simin, Nathaniel Hafer, and David D. McManus

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Barriers and Facilitators to Implementation of Value-Based Care Models in New Medicaid Accountable Care Organizations in Massachusetts: A Study Protocol, Sarah L. Goff, Deborah Gurewich, Matthew J. Alcusky, Aparna Kachoria, Joanne Nicholson, and Jay S. Himmelstein

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Peripartum depression: Does risk versus diagnostic status impact mother-infant bonding and perceived social support, Megan M. Hare, Aimee Kroll-Desrosiers, and Kristina M. Deligiannidis

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Challenges in defining Long COVID: Striking differences across literature, Electronic Health Records, and patient-reported information [preprint], Halie M. Rando, Feifan Liu, and Melissa A. Haendel

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Longitudinal assessment of diagnostic test performance over the course of acute SARS-CoV-2 infection [preprint], Rebecca L. Smith, Laura L. Gibson, Alyssa N. Owens, John P. Broach, Bruce A. Barton, Peter Lazar, David D. McManus, and Christopher B. Brooke

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National Trends in Statin Use among the United States Nursing Home Population (2011-2016), Deborah Mack, Anne L. Hume, Jennifer Tjia, and Kate L. Lapane

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Adapting a Traumatic Brain Injury Goals-of-Care Decision Aid for Critically Ill Patients to Intracerebral Hemorrhage and Hemispheric Acute Ischemic Stroke, Kelsey Goostrey, Christopher Lee, Kelsey Jones, Thomas Quinn, Jesse Moskowitz, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, Kathleen M. Mazor, David Y. Hwang, and Susanne Muehlschlegel

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Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis, Pasquale Piccolo, Florie Borel, Christian Mueller, and Nicola Brunetti-Pierri

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The Inverse OARSI-OMERACT Criteria Is a Valid Indicator of the Clinical Worsening of Knee Osteoarthritis: Data From the Osteoarthritis Initiative, Jeffrey B. Driban, Matthew S. Harkey, Lori Lyn. Price, Grace H. Lo, and Timothy E. McAlindon

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Development and psychometric evaluation of the Social Connectedness Index in nursing home residents with Alzheimer's disease and dementia using the Minimum Data Set 3.0, Carol A. Bova, William M. Jesdale, Attah Mbrah, Lynn Botelho, and Kate L. Lapane

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Variation in Colorectal Cancer Screening Practices According to Cardiovascular Disease Status and Race/Ethnicity, Maira A. Castaneda-Avila, Kate L. Lapane, William M. Jesdale, Sybil L. Crawford, and Mara M. Epstein

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The National COVID Cohort Collaborative: Clinical Characterization and Early Severity Prediction [preprint], Tellen D. Bennett, Christopher G. Chute, and N3C Consortium

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Health Care Satisfaction in Relation to Gender Identity: Behavioral Risk Factor Surveillance Survey, 20 States (2014-2018), Katarina A. Ferrucci, Tubanji Walubita, Ariel L. Beccia, Eric Y. Ding, William M. Jesdale, Kate L. Lapane, and Carl G. Streed Jr.

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Impact of Patient Access to Online VA Notes on Healthcare Utilization and Clinician Documentation: a Retrospective Cohort Study, Amanda C. Blok, Daniel J. Amante, Timothy P. Hogan, Rajani S. Sadasivam, Stephanie L. Shimada, Susan Woods, Kim M. Nazi, and Thomas K. Houston

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The relationship between restless sleep and symptoms of the knee: data from the Osteoarthritis Initiative, Kate L. Lapane, Divya Shridharmurthy, Matthew S. Harkey, Jeffrey B. Driban, Catherine E. Dube, and Shao-Hsien Liu

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Geographic Variation in Anticoagulant Use and Resident, Nursing Home, and County Characteristics Associated With Treatment Among US Nursing Home Residents, Matthew Alcusky, Jonggyu Baek, Jennifer Tjia, David D. McManus, and Kate L. Lapane

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Creating the Capacity to Screen Deaf Women for Perinatal Depression: A Pilot Study, Melissa L. Anderson, Kelly S. Wolf Craig, Sheri Hostovsky, Maureen Bligh, Emily Bramande, Kristin Walker, Kathleen Biebel, and Nancy Byatt

Publications from 2020

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Rigor and reproducibility training for first year medical students in research pathways, Kate L. Lapane and Catherine E. Dube

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Statin Discontinuation and Life-Limiting Illness in Non-Skilled Stay Nursing Homes at Admission, Deborah S. Mack, Jonggyu Baek, Jennifer Tjia, and Kate L. Lapane

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Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions, Milka Koupenova-Zamor and Jane E. Freedman

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New Opportunities and Cautionary Insights about Decentralizing and Deglobalizing Clinical Trials During the Great Lockdown, Denise Dunlap, Roberto S. Santos, David D. McManus, Bryan O. Buchholz, Nathaniel S. Hafer, and MaryAnn Picard

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English language proficiency, complete tooth loss, and recent dental visits among older adults in the United States, Andriana M. Foiles Sifuentes, Maira A. Castaneda-Avila, and Kate L. Lapane

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Red blood cell membrane trans fatty acid levels and risk of non-Hodgkin lymphoma: a prospective nested case-control study, Andres V. Ardisson Korat, Yu-Han Chiu, Kimberly A. Bertrand, Shumin Zhang, Mara M. Epstein, Bernard A. Rosner, Stephanie Chiuve, Hannia Campos, Edward L. Giovannucci, Jorge E. Chavarro, and Brenda M. Birmann

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The association of non-alcoholic fatty liver disease and cardiac structure and function-Framingham Heart Study, Laura S. Chiu, Alison Pedley, Joseph M. Massaro, Emelia J. Benjamin, Gary F. Mitchell, David D. McManus, Jayashri Aragam, Ramachandran S. Vasan, Susan Cheng, and Michelle T. Long

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Hyperchloremia, not Concomitant Hypernatremia, Independently Predicts Early Mortality in Critically Ill Moderate-Severe Traumatic Brain Injury Patients, Kristen L. Ditch, Julie M. Flahive, Ashley M. West, Marcey Osgood, and Susanne Muehlschlegel

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Association of Use of an Integrated Specialty Pharmacy With Total Medical Expenditures Among Members of an Accountable Care Organization, Apurv Soni, Brian S. Smith, Thomas Scornavacca, Bill McElnea, Alice Shakman, Eric W. Dickson, and David D. McManus

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Primary care physician perspectives on barriers to diagnosing axial Spondyloarthritis: a qualitative study, Kate L. Lapane, Sara Khan, Divya Shridharmurthy, Ariel Beccia, Catherine E. Dube, Esther Yi, Jonathan Kay, and Shao-Hsien Liu

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Prostate-specific antigen testing after the US Preventive Services Task Force recommendation: a population-based analysis of electronic health data, Daniel M. Frendl, Mara M. Epstein, Hassan Fouayzi, Richard Krajenta, Benjamin A. Rybicki, and Mitchell H. Sokoloff

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Racial/Ethnic Differences in Staff-Assessed Pain Behaviors Among Newly Admitted Nursing Home Residents, Reynolds A. Morrison, William M. Jesdale, Catherine E. Dube, Sarah N. Forrester, Anthony P. Nunes, Carol A. Bova, and Kate L. Lapane

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An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes, Nathan D. Lawson, Rui Li, Masahiro Shin, Ann S. Grosse, Onur Yukselen, Oliver A. Stone, Alper Kucukural, and Lihua Julie Zhu

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Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study, Aditya Vaze, Khanh-Van T. Tran, Kahraman Tanriverdi, Mayank Sardana, Darleen M. Lessard, J. Kevin Donahue, Bruce A. Barton, Gerard P. Aurigemma, Amiya Mandapati, Jane E. Freedman, and David D. McManus

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Reduced Neurog3 Gene Dosage Shifts Enteroendocrine Progenitor Toward Goblet Cell Lineage in the Mouse Intestine, Joyce H. Li, Subir Ray, Alper Kucukural, Gerard Gradwohl, and Andrew B. Leiter

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Epstein-Barr Virus Genomes Reveal Population Structure and Type 1 Association with Endemic Burkitt Lymphoma, Yasin Kaymaz, Cliff I. Oduor, Ozkan Aydemir, Micah A. Luftig, Juliana A. Otieno, John Michael. Ong'echa, Jeffrey A. Bailey, and Ann M. Moormann

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The relationship of aging, complete tooth loss, and having a dental visit in the last 12 months, Andriana M. Foiles Sifuentes, Maira Castaneda-Avila, and Kate L. Lapane

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Outside Our Walls: the Case for City-Wide Collaboration to Reduce Disparities, Jennifer S. Haas, Stephenie C. Lemon, Karen M. Freund, Tracy A. Battaglia, and Translating Research Into Practice (TRIP) Consortium Writing Group

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Does Home Remedy Use Contribute to Medication Nonadherence Among Blacks with Hypertension, Yendelela L. Cuffee, Milagros C. Rosal, J. Lee Hargraves, Becky A. Briesacher, Suzanne Akuley, Noof Altwatban, Sandral Hullett, and Jeroan J. Allison

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Quantitative HIV-1-specific antibodies as predictors of peripheral blood cell-associated HIV-1 DNA concentrations, Margaret M. McManus, Brad Karalius, Kunjal Patel, Deborah Persaud, Katherine Luzuriaga, and Pediatric HIV/AIDS Cohort Study

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Goals-of-care decision aid for critically ill patients with TBI: Development and feasibility testing, Susanne Muehlschlegel, David Y. Hwang, Julie M. Flahive, Thomas Quinn, Christopher Lee, Jesse Moskowitz, Kelsey Goostrey, Kelsey Jones, Jolanta J. Pach, Andrea K. Knies, Lori Shutter, Robert J. Goldberg, and Kathleen M. Mazor

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A Decline in Walking Speed is Associated with Incident Knee Replacement in Adults with and at Risk for Knee Osteoarthritis, Matthew S. Harkey, Kate L. Lapane, Shao-Hsien Liu, Grace H. Lo, Timothy E. McAlindon, and Jeffrey B. Driban

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The 'Take a Break' game: Randomized trial protocol for a technology-assisted brief abstinence experience designed to engage lower-motivated smokers., Daniel J. Amante, Amanda C. Blok, Catherine S. Nagawa, Jessica G. Wijesundara, Jeroan J. Allison, Sharina D. Person, Jeanne Morley, Joseph Conigliaro, Kristin M. Mattocks, Lawrence D. Garber, Thomas K. Houston, and Rajani S. Sadasivam

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Advances in Understanding the Causes and Consequences of Health Disparities in Aging Minorities, Sarah N. Forrester, Janiece L. Taylor, Keith E. Whitfield, and Roland J. Thorpe Jr.