This collection showcases the journal articles and other publications authored by researchers in the Thompson Lab in the Department of Biochemistry and Molecular Pharmacology at the University of Massachusetts Medical School.

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Publications from 2010

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Mechanistic studies of agmatine deiminase from multiple bacterial species, Justin E. Jones, Christina J. Dreyton, Heather Flick, Corey P. Causey, and Paul R. Thompson

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Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3, Bryan Knuckley, Corey P. Causey, Justin E. Jones, Monica Bhatia, Christina J. Dreyton, Tanesha C. Osborne, Hidenari Takahara, and Paul R. Thompson

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Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation, Bryan Knuckley, Corey P. Causey, Perry J. Pellechia, Paul F. Cook, and Paul R. Thompson

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A fluopol-ABPP HTS assay to identify PAD inhibitors, Bryan Knuckley, Justin E. Jones, Daniel A. Bachovchin, Jessica Slack, Corey P. Causey, Steven J. Brown, Hugh Rosen, Benjamin F. Cravatt, and Paul R. Thompson

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A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation, Obiamaka Obianyo, Corey P. Causey, Tanesha C. Osborne, Justin E. Jones, Young-Ho Lee, Michael R. Stallcup, and Paul R. Thompson

Publications from 2009

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Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential, Justin E. Jones, Corey P. Causey, Bryan Knuckley, Jessica L. Slack-Noyes, and Paul R. Thompson

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The tomato brassinosteroid receptor BRI1 increases binding of systemin to tobacco plasma membranes, but is not involved in systemin signaling, Robert Malinowski, Rebecca Higgins, Yuan Luo, Laverne Piper, Azka Nazir, Vikramjit S. Bajwa, Steven D. Clouse, Paul R. Thompson, and Johannes W. Stratmann

Publications from 2008

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The protein acetyltransferase ARD1: a novel cancer drug target, Thomas Arnesen, Paul R. Thompson, Jan Erik. Varhaug, and Johan R. Lillehaug

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An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4), Corey P. Causey and Paul R. Thompson

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Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors, Bryan Knuckley, Yuan Luo, and Paul R. Thompson

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Regulation of p53 target gene expression by peptidylarginine deiminase 4, Pingxin Li, Hongjie Yao, Zhiqiang Zhang, Ming Li, Yuan Luo, Paul R. Thompson, David S. Gilmour, and Yanming Wang

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The structural basis of protein acetylation by the p300/CBP transcriptional coactivator, Xin Liu, Ling Wang, Kehao Zhao, Paul R. Thompson, Yousang Hwang, Ronen Marmorstein, and Philip A. Cole

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Kinetic mechanism of protein arginine methyltransferase 1, Obiamaka Obianyo, Tanesha C. Osborne, and Paul R. Thompson

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In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1, Tanesha C. Osborne, Rachel L. Roska Weller, Scott R. Rajski, and Paul R. Thompson

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Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis, Hongjie Yao, Pingxin Li, Bryan J. Venters, Suting Zheng, Paul R. Thompson, B. Franklin Pugh, and Yanming Wang

Publications from 2007

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Methyllysine analogs: rewriting the code, Monica Bhatia and Paul R. Thompson

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A selective chemical probe for coenzyme A-requiring enzymes, Yousang Hwang, Paul R. Thompson, Ling Wang, Lihua Jiang, Neil L. Kelleher, and Philip A. Cole

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Protein arginine deiminase 4: evidence for a reverse protonation mechanism, Bryan Knuckley, Monica Bhatia, and Paul R. Thompson

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Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis, Tanesha C. Osborne, Obiamaka Obianyo, Xing Zhang, Xiaodong Cheng, and Paul R. Thompson

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Peptide borono lectins (PBLs): a new tool for glycomics and cancer diagnostics, Yuejiao Zou, Dana L. Broughton, Kevin L. Bicker, Paul R. Thompson, and John J. Lavigne

Publications from 2006

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Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization, Yuan Luo, Kyouhei Arita, Monica Bhatia, Bryan Knuckley, Young-Ho Lee, Michael R. Stallcup, Mamoru Sato, and Paul R. Thompson

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Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe, Yuan Luo, Bryan Knuckley, Monica Bhatia, Perry J. Pellechia, and Paul R. Thompson

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A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation, Yuan Luo, Bryan Knuckley, Young-Ho Lee, Michael R. Stallcup, and Paul R. Thompson

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Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock, Paul R. Thompson and Walter Fast

Publications from 2005

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Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis, Patricia L. Kearney, Monica Bhatia, Nelroy G. Jones, Luo Yuan, Mary C. Glascock, Kristen L. Catchings, Michiyuki Yamada, and Paul R. Thompson

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Structural analysis of a highly acetylated protein using a curved-field reflectron mass spectrometer, Dongxia Wang, Paul R. Thompson, Philip A. Cole, and Robert J. Cotter

Publications from 2004

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Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors, Vatsala Sagar, Weiping Zheng, Paul R. Thompson, and Philip A. Cole

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Regulation of the p300 HAT domain via a novel activation loop, Paul R. Thompson, Dongxia Wang, Ling Wang, Marcella Fulco, Natalia Pediconi, Dianzheng Zhang, Woojin An, Qingyuan Ge, Robert G. Roeder, Jiemin Wong, Massimo Levrero, Vittorio Sartorelli, Robert J. Cotter, and Philip A. Cole

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Selective HAT inhibitors as mechanistic tools for protein acetylation, Yujun Zheng, Paul R. Thompson, Marek Cebrat, Ling Wang, Meghann K. Devlin, Rhoda M. Alani, and Philip A. Cole

Publications from 2003

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Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300, Marek Cebrat, Cheol M. Kim, Paul R. Thompson, Matthew Daugherty, and Philip A. Cole

Publications from 2002

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Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop, Paul R. Thompson, David D. Boehr, Albert M. Berghuis, and Gerard D. Wright

Publications from 2001

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Molecular mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: roles of conserved active site residues, D. D. Boehr, Paul R. Thompson, and G. D. Wright

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Probing the mechanism of enzymatic phosphoryl transfer with a chemical trick, Paul R. Thompson and P. A. Cole

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Transcriptional coactivator protein p300. Kinetic characterization of its histone acetyltransferase activity, Paul R. Thompson, H. Kurooka, Y. Nakatani, and P. A. Cole

Publications from 2000

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Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases, B. DeLaBarre, Paul R. Thompson, G. D. Wright, and A. M. Berghuis

Publications from 1999

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Aminoglycoside antibiotic phosphotransferases are also serine protein kinases, D. M. Daigle, G. A. McKay, Paul R. Thompson, and G. D. Wright

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The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance, Paul R. Thompson, J. Schwartzenhauer, D. W. Hughes, A. M. Berghuis, and G. D. Wright

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Aminoglycoside phosphotransferases: proteins, structure, and mechanism, G. D. Wright and Paul R. Thompson

Publications from 1998

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Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues, Paul R. Thompson, D. W. Hughes, N. P. Cianciotto, and G. D. Wright

Publications from 1997

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Structure of an enzyme required for aminoglycoside antibiotic resistance reveals homology to eukaryotic protein kinases, W. C. Hon, G. A. McKay, Paul R. Thompson, R. M. Sweet, D. S. Yang, G. D. Wright, and A. M. Berghuis

Publications from 1996

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Mechanism of aminoglycoside 3'-phosphotransferase type IIIa: His188 is not a phosphate-accepting residue, Paul R. Thompson, D. W. Hughes, and G. D. Wright

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Regiospecificity of aminoglycoside phosphotransferase from Enterococci and Staphylococci (APH(3')-IIIa), Paul R. Thompson, D. W. Hughes, and G. D. Wright

Publications from 1994

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Broad spectrum aminoglycoside phosphotransferase type III from Enterococcus: overexpression, purification, and substrate specificity, G. A. McKay, Paul R. Thompson, and G. D. Wright