Title
Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
2006-08-22
Document Type
Article
Subjects
Arginine; Chemistry; Citrulline; *Gene Expression Regulation, Enzymologic; Histones; Hydrolases; Methylation; Models, Chemical; Models, Molecular; Multigene Family; Protein Conformation; Protein Processing, Post-Translational; Proteomics
Disciplines
Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry | Therapeutics
Abstract
Protein citrullination, a once-obscure post-translational modification (PTM) of peptidylarginine, has recently become an area of significant interest because of its suspected role in human disease states, including rheumatoid arthritis and multiple sclerosis, and also because of its newfound role in gene regulation. One protein isozyme responsible for this modification, protein arginine deiminase 4 (PAD4), has also been proposed to "reverse" epigenetic histone modifications made by the protein arginine methyltransferases. Here, we review the in vivo and in vitro studies of transcriptional regulation by PAD4, evaluate conflicting evidence for its ability to use methylated peptidylarginine as a substrate, and highlight promising areas of future work. Understanding the interplay of multiple arginine PTMs is an emerging area of importance in health and disease and is a topic best addressed by novel tools in proteomics and chemical biology.
DOI of Published Version
10.1021/cb6002306
Source
ACS Chem Biol. 2006 Aug 22;1(7):433-41. Link to article on publisher's site
Journal/Book/Conference Title
ACS chemical biology
Related Resources
Repository Citation
Thompson PR, Fast W. (2006). Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock. Thompson Lab Publications. https://doi.org/10.1021/cb6002306. Retrieved from https://escholarship.umassmed.edu/thompson/79
Comments
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.