Title
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
2009-09-01
Document Type
Article
Subjects
Animals; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Catalysis; Drug Design; *Drug Discovery; Enzyme Inhibitors; Humans; Hydrolases; Immunologic Factors; Isoenzymes; Models, Molecular; Molecular Structure; Multiple Sclerosis; Neoplasms; Protein Conformation; Structure-Activity Relationship
Disciplines
Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry | Therapeutics
Abstract
The protein arginine deiminases (PADs), and in particular PAD4, have emerged as potential therapeutic targets for the treatment of rheumatoid arthritis (RA). In this review, evidence linking dysregulated PAD activity to the onset and progression of RA is presented, and the potential role of such aberrant activity in other human diseases, such as multiple sclerosis and cancer, is discussed. The known physiological roles of the PADs, particularly PAD4, and current knowledge regarding PAD structure, catalysis and inhibition are also described.
Keywords
Protein Arginine Deiminase, Rheumatoid Arthritis, Multiple Sclerosis, Cancer, Treatment, Inhibitors
Source
Curr Opin Drug Discov Devel. 2009 Sep;12(5):616-27.
Journal/Book/Conference Title
Current opinion in drug discovery and development
Related Resources
Repository Citation
Jones, Justin E.; Causey, Corey P.; Knuckley, Bryan; Slack-Noyes, Jessica L.; and Thompson, Paul R., "Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential" (2009). Thompson Lab Publications. 62.
https://escholarship.umassmed.edu/thompson/62
Comments
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.