Title

A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation

UMMS Affiliation

Department of Biochemistry and Molecular Pharmacology

Publication Date

6-14-2010

Document Type

Article

Subjects

Amidines; Arginine; Catalytic Domain; Cell Line; Enzyme Inhibitors; Humans; Methylation; Peptides; Protein-Arginine N-Methyltransferases

Disciplines

Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry | Therapeutics

Keywords

Cl-amidine, enzymes, inhibitors, protein arginine methyltransferase, transcription

DOI of Published Version

10.1002/cbic.201000209

Source

Chembiochem. 2010 Jun 14;11(9):1219-23. doi: 10.1002/cbic.201000209. Link to article on publisher's site

Journal/Book/Conference Title

Chembiochem : a European journal of chemical biology

Comments

At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.

Related Resources

Link to Article in PubMed