Title
A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation
UMMS Affiliation
Department of Biochemistry and Molecular Pharmacology
Publication Date
2010-06-14
Document Type
Article
Subjects
Amidines; Arginine; Catalytic Domain; Cell Line; Enzyme Inhibitors; Humans; Methylation; Peptides; Protein-Arginine N-Methyltransferases
Disciplines
Biochemistry | Enzymes and Coenzymes | Medicinal-Pharmaceutical Chemistry | Therapeutics
Keywords
Cl-amidine, enzymes, inhibitors, protein arginine methyltransferase, transcription
DOI of Published Version
10.1002/cbic.201000209
Source
Chembiochem. 2010 Jun 14;11(9):1219-23. doi: 10.1002/cbic.201000209. Link to article on publisher's site
Journal/Book/Conference Title
Chembiochem : a European journal of chemical biology
Related Resources
Repository Citation
Obianyo, Obiamaka; Causey, Corey P.; Osborne, Tanesha C.; Jones, Justin E.; Lee, Young-Ho; Stallcup, Michael R.; and Thompson, Paul R., "A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation" (2010). Thompson Lab Publications. 59.
https://escholarship.umassmed.edu/thompson/59
Comments
At the time of publication, Paul Thompson was not yet affiliated with UMass Medical School.