Tapper Lab Publications

 

This collection showcases the journal articles and other publications authored by researchers in the Tapper Lab. The Lab at the University of Massachusetts Medical School was established in the Brudnick Neuropsychiatric Research Institute, in the Department of Psychiatry. In 2017, the Tapper Lab moved to the Department of Neurobiology.

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Publications from 2020

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Integrated miRNA-/mRNA-Seq of the Habenulo-Interpeduncular Circuit During Acute Nicotine Withdrawal, Alison P. Casserly, Junko Tsuji, Rubing Zhao-Shea, Ciearra B. Smith, Susanna Molas-Casacuberta, Andrew R. Tapper, Zhiping Weng, and Paul D. Gardner

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Midbrain Dopamine Controls Anxiety-like Behavior by Engaging Unique Interpeduncular Nucleus Microcircuitry, Steven R. DeGroot, Rubing Zhao-Shea, Leeyup Chung, Paul M. Klenowski, Fangmiao Sun, Susanna Molas-Casacuberta, Paul D. Gardner, Yulong Li, and Andrew R. Tapper

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Midbrain circuits of novelty processing, Andrew R. Tapper and Susanna Molas Casacuberta

Publications from 2019

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Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling, Georgia Gunner, Kasey M. Johnson, Erica Mondo, Liwang Liu, Andrew R. Tapper, and Dorothy P. Schafer

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Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function [preprint], Carolyn G. Sweeney, Patrick Kearney, Rita R. Fagan, Lindsey A. Smith, Nicholas C. Bolden, Rubing Zhao-Shea, Iris V. Rivera, Jenya Kolpakova, Jun Xie, Guangping Gao, Andrew R. Tapper, Gilles E. Martin, and Haley Melikian

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Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function, Carolyn G. Sweeney, Patrick J. Kearney, Rita R. Fagan, Lindsey A. Smith, Nicholas C. Bolden, Rubing Zhao-Shea, Iris V. Rivera, Jenya Kolpakova, Jun Xie, Guangping Gao, Andrew R. Tapper, Gilles E. Martin, and Haley Melikian

Publications from 2018

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Molecular, Neuronal, and Behavioral Effects of Ethanol and Nicotine Interactions, Paul M. Klenowski and Andrew R. Tapper

Publications from 2017

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The Sodium Channel beta4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons, Xincai Ji, Sucharita Saha, Guangping Gao, Amy W. Lasek, Gregg E. Homanics, Melissa Guildford Derner, Andrew R. Tapper, and Gilles E. Martin

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Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity of the Core Nucleus Accumbens Direct and Indirect Pathways, Xincai Ji, Sucharita Saha, Jenya Kolpakova, Melissa Guildford, Andrew R. Tapper, and Gilles E. Martin

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Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis, Susanna Molas-Casacuberta, Steven Degroot, Rubing Zhao-Shea, and Andrew R. Tapper

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A circuit-based mechanism underlying familiarity signaling and the preference for novelty, Susanna Molas-Casacuberta, Rubing Zhao-Shea, Liwang Liu, Steven Degroot, Paul D. Gardner, and Andrew R. Tapper

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Paternal nicotine exposure alters hepatic xenobiotic metabolism in offspring, Markus P. Vallaster, Shweta Kukreja, Xin Y. Bing, Jennifer Ngolab, Rubing Zhao-Shea, Paul D. Gardner, Andrew R. Tapper, and Oliver J. Rando

Publications from 2016

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Sex, Drugs, and Rodent Reward: An Exploration of the Sex-Specific Roles of Nicotinic Acetylcholine Receptors in Ethanol Reward, Melissa Guildford Derner

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Modulation of ethanol reward sensitivity by nicotinic acetylcholine receptors containing the alpha6 subunit, Melissa Guildford Derner, Anthony V. Sacino, and Andrew R. Tapper

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Habenula cholinergic neurons regulate anxiety during nicotine withdrawal via nicotinic acetylcholine receptors, Xueyan Pang, Liwang Liu, Jennifer Ngolab, Rubing Zhao-Shea, J. Michael McIntosh, Paul D. Gardner, and Andrew R. Tapper

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Nicotine Enhances the Hypnotic and Hypothermic Effects of Alcohol in the Mouse, Cassandra A. Slater, Asti Jackson, Pretal P. Muldoon, Anton Dawson, Megan O'Brien, Lindsey G. Soll, Rehab Abdullah, F. Ivy Carroll, Andrew R. Tapper, Michael F. Miles, Matthew L. Banks, Jill C. Bettinger, and Imad M. Damaj

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5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking, In-Jee You, Sherie R. Wright, Alvaro L. Garcia-Garcia, Andrew R. Tapper, Paul D. Gardner, George F. Koob, E David Leonardo, Laura M. Bohn, and Sunmee Wee

Publications from 2015

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The Role of VTA Gabaergic Nicotinic Acetylcholine Receptors Containing the α4 Subunit in Nicotine Dependence: A Dissertation, Jennifer Ngolab

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Functional Upregulation of alpha4* Nicotinic Acetylcholine Receptors in VTA GABAergic Neurons Increases Sensitivity to Nicotine Reward, Jennifer Ngolab, Liwang Liu, Rubing Zhao-Shea, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

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The Role of Medial Habenula-Interpeduncular Nucleus Pathway in Anxiety: A Dissertation, Xueyan Pang

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Genetic and Epigenetic Variation, but Not Diet, Shape the Sperm Methylome, Jeremy Shea, Ryan W. Serra, Benjamin R. Carone, Hennady P. Shulha, Alper Kucukural, Michael Ziller, Markus Vallaster, Hongcang Gu, Andrew R. Tapper, Paul D. Gardner, Alexander Meissner, Manuel Garber, and Oliver J. Rando

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Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal, Rubing Zhao-Shea, Steven Degroot, Liwang Liu, Markus Vallaster, Xueyan Pang, Qin Su, Guangping Gao, Oliver J. Rando, Gilles E. Martin, Olivier George, Paul D. Gardner, and Andrew R. Tapper

Publications from 2014

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VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation, Taryn E. Grieder, Andrew R. Tapper, and Olivier George

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miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family, Eric M. Hogan, Alison P. Casserly, Michael D. Scofield, Zhongming Mou, Rubing Zhao-Shea, Chris W. Johnson, Andrew R. Tapper, and Paul D. Gardner

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Dicer expression is essential for adult midbrain dopaminergic neuron maintenance and survival, Xueyan Pang, Eric M. Hogan, Alison Casserly, Guangping Gao, Paul D. Gardner, and Andrew R. Tapper

Publications from 2013

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Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons, Sandra Almeida, Eduardo Gascon, Helene Tran, Hsin-Jung Chou, Tania F. Gendron, Steven Degroot, Andrew R. Tapper, Chantal Sellier, Nicolas Charlet-Berguerand, Anna Karydas, William W. Seeley, Adam L. Boxer, Leonard Petrucelli, Bruce L. Miller, and Fen-Biao Gao

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Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence, Linzy M. Hendrickson, Melissa Guildford, and Andrew R. Tapper

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Nicotinic acetylcholine receptors mediate lung cancer growth, Ma. Reina D. Improgo, Lindsey G. Soll, Andrew R. Tapper, and Paul D. Gardner

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Nicotinic acetylcholine receptors containing the alpha4 subunit modulate alcohol reward, Liwang Liu, Linzy M. Hendrickson, Melissa Guildford, Rubing Zhao-Shea, Paul D. Gardner, and Andrew R. Tapper

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Nicotinic acetylcholine receptors containing the alpha6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons, Liwang Liu, Rubing Zhao-Shea, J. Michael McIntosh, and Andrew R. Tapper

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A Role for Neuronal Nicotinic Acetylcholine Receptors in Dopamine-Mediated Behaviors and the Hypnotic Response to Anesthetics: A Dissertation, Lindsey G. Soll

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A role for alpha4(non-alpha6)* nicotinic acetylcholine receptors in motor behavior, Lindsey G. Soll, Sharon R. Grady, Outi Salminen, Michael J. Marks, and Andrew R. Tapper

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Activation of GABAergic Neurons in the Interpeduncular Nucleus Triggers Physical Nicotine Withdrawal Symptoms, Rubing Zhao-Shea, Liwang Liu, Xueyan Pang, Paul D. Gardner, and Andrew R. Tapper

Publications from 2012

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Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing alpha4 and alpha6 subunits, Liwang Liu, Rubing Zhao-Shea, J. Michael McIntosh, Paul D. Gardner, and Andrew R. Tapper

Publications from 2011

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Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis, Heather L. Armata, Punita Shroff, David S. Garlick, Krista L. Penta, Andrew R. Tapper, and Hayla Karen Sluss

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Neuronal Nicotinic Acetylcholine Receptors: Molecular Targets for Alcoholism and Ethanol Reward: A Dissertation, Linzy M. Hendrickson

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Nicotinic acetylcholine receptors containing the alpha4 subunit are critical for the nicotine-induced reduction of acute voluntary ethanol consumption, Linzy M. Hendrickson, Paul D. Gardner, and Andrew R. Tapper

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Bioluminescence-based high-throughput screen identifies pharmacological agents that target neurotransmitter signaling in small cell lung carcinoma, Ma. Reina D. Improgo, Christopher W. Johnson, Andrew R. Tapper, and Paul D. Gardner

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Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer, Ma. Reina D. Improgo, Andrew R. Tapper, and Paul D. Gardner

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Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area, Rubing Zhao-Shea, Liwang Liu, Lindsey G. Soll, Ma. Reina D. Improgo, Erin E. Meyers, J. Michael McIntosh, Sharon R. Grady, Michael J. Marks, Paul D. Gardner, and Andrew R. Tapper

Publications from 2010

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Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption, Linzy M. Hendrickson, Rubing Zhao-Shea, Xueyan Pang, Paul D. Gardner, and Andrew R. Tapper

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ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus, Ma Reina D. Improgo, Nicolette A. Schlichting, Roxana Y. Cortes, Rubing Zhao-Shea, Andrew R. Tapper, and Paul D. Gardner

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The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer, Ma Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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From smoking to lung cancer: the CHRNA5/A3/B4 connection, Ma. Reina D. Improgo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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A transcriptional regulatory element critical for CHRNB4 promoter activity in vivo, Michael D. Scofield, Andrew R. Tapper, and Paul D. Gardner

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Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism, Rubing Zhao-Shea, Bruce M. Cohen, Herwig Just, Tristan McClure-Begley, Paul Whiteaker, Sharon R. Grady, Outi Salminen, Paul D. Gardner, Henry A. Lester, and Andrew R. Tapper

Publications from 2009

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Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice, Linzy M. Hendrickson, Rubing Zhao-Shea, and Andrew R. Tapper

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The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10, Zhongming Mou, Andrew R. Tapper, and Paul D. Gardner

Publications from 2008

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Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol, Gilles E. Martin, Linzy M. Hendrickson, Krista L. Penta, Ryan M. Friesen, Andrzej Z. Pietrzykowski, Andrew R. Tapper, and Steven N. Treistman

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Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors, Frederick Albert Schroeder, Krista L. Penta, Anouch Matevossian, Sara R. Jones, Christine L. Konradi, Andrew R. Tapper, and Schahram Akbarian