Title

Mapping the 3D genome: Aiming for consilience

UMMS Affiliation

Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology

Publication Date

2016-11-21

Document Type

Response or Comment

Disciplines

Biochemistry, Biophysics, and Structural Biology | Cell Biology | Genetics and Genomics | Systems Biology

Abstract

The spatial organization of genomes is studied using microscopy- and chromosome conformation capture (3C)-based methods. The two types of methods produce data that are often consistent, but there are cases where they appear discordant. These cases provide opportunities to derive better models of chromatin folding, which can reconcile the datasets.

Keywords

Chromosome conformation capture-based methods, Microscopy, Nuclear organization

DOI of Published Version

10.1038/nrm.2016.151

Source

Nat Rev Mol Cell Biol. 2016 Nov 21;17(12):741-742. doi: 10.1038/nrm.2016.151. Link to article on publisher's site

Journal/Book/Conference Title

Nature reviews. Molecular cell biology

Related Resources

Link to Article in PubMed

PubMed ID

27869158

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