Title
The 3D Genome as Moderator of Chromosomal Communication
UMMS Affiliation
Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology
Publication Date
3-10-2016
Document Type
Article
Disciplines
Biochemistry | Biophysics | Computational Biology | Genomics | Molecular Biology | Structural Biology | Systems Biology
Abstract
Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.
Keywords
CTCF, Hi-C, biophysics, cohesin, condensin, domains, enhancer, gene expression, gene regulation, polymers, promoter, simulations
DOI of Published Version
10.1016/j.cell.2016.02.007
Source
Cell. 2016 Mar 10;164(6):1110-21. doi: 10.1016/j.cell.2016.02.007. Link to article on publisher's site
Journal/Book/Conference Title
Cell
Related Resources
PubMed ID
26967279
Repository Citation
Dekker, Job and Mirny, Leonid A., "The 3D Genome as Moderator of Chromosomal Communication" (2016). Program in Systems Biology Publications and Presentations. 79.
https://escholarship.umassmed.edu/sysbio_pubs/79