Long-Range Chromatin Interactions
Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology
Genomics | Molecular Biology | Systems Biology
To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.
DOI of Published Version
Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10). pii: a019356. doi: 10.1101/cshperspect.a019356.. Link to article on publisher's site
Cold Spring Harbor perspectives in biology
Dekker, Job and Misteli, Tom, "Long-Range Chromatin Interactions" (2015). Program in Systems Biology Publications and Presentations. 74.