Title

Long-Range Chromatin Interactions

UMMS Affiliation

Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology

Publication Date

2015-10-01

Document Type

Article

Disciplines

Genomics | Molecular Biology | Systems Biology

Abstract

To accommodate genomes in the limited space of the cell nucleus and ensure the correct execution of gene expression programs, genomes are packaged in complex fashion in the three-dimensional cell nucleus. As a consequence of the extensive higher-order organization of chromosomes, distantly located genomic regions on the same or distinct chromosomes undergo long-range interactions. This article discusses the nature of long interactions, mechanisms of their formation, and their emerging functional roles in gene regulation and genome maintenance.

DOI of Published Version

10.1101/cshperspect.a019356

Source

Cold Spring Harb Perspect Biol. 2015 Oct 1;7(10). pii: a019356. doi: 10.1101/cshperspect.a019356.. Link to article on publisher's site

Journal/Book/Conference Title

Cold Spring Harbor perspectives in biology

Related Resources

Link to Article in PubMed

PubMed ID

26430217

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