Title

Let a hundred flowers bloom: the role of context dependence in creating phenotypic diversity following targeted therapy

UMMS Affiliation

Program in Systems Biology

Publication Date

2015-03-05

Document Type

Article

Disciplines

Cancer Biology | Cell Biology | Computational Biology | Molecular Biology | Systems Biology

Abstract

Using a newly developed computational platform, COSPER, Litvin et al. (2015) identify context-dependent interactions between MEK and interferon signaling that underlie sensitivity and resistance to MEK inhibition in melanoma.

DOI of Published Version

10.1016/j.molcel.2015.02.030

Source

Mol Cell. 2015 Mar 5;57(5):763-4. doi: 10.1016/j.molcel.2015.02.030. Link to article on publisher's site

Journal/Book/Conference Title

Molecular cell

Related Resources

Link to Article in PubMed

PubMed ID

25747655

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