A closer look at long-range chromosomal interactions

UMMS Affiliation

Program in Gene Function and Expression; Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology

Publication Date


Document Type



Animals; Binding Sites; Chromatin; Chromosome Mapping; DNA; Globins; Humans; Locus Control Region


Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics | Systems Biology


Higher-order chromosome organization is emerging as a major determinant of gene regulation. Although the structure of chromatin at the level of individual nucleosomes has been studied in considerable detail, less is known about higher levels of organization. Two new methods have been developed that can be used to obtain detailed information about the higher-order folding of chromatin. Using these methods, long-range looping interactions have been shown to occur upon activation of the murine beta-globin locus, explaining the long-standing question of how gene regulatory elements can act at large genomic distances from their target genes.

DOI of Published Version



Trends Biochem Sci. 2003 Jun;28(6):277-80. Link to article on publisher's site

Journal/Book/Conference Title

Trends in biochemical sciences

Related Resources

Link to Article in PubMed

PubMed ID