A closer look at long-range chromosomal interactions
Program in Gene Function and Expression; Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology
Animals; Binding Sites; Chromatin; Chromosome Mapping; DNA; Globins; Humans; Locus Control Region
Biochemistry, Biophysics, and Structural Biology | Genetics and Genomics | Systems Biology
Higher-order chromosome organization is emerging as a major determinant of gene regulation. Although the structure of chromatin at the level of individual nucleosomes has been studied in considerable detail, less is known about higher levels of organization. Two new methods have been developed that can be used to obtain detailed information about the higher-order folding of chromatin. Using these methods, long-range looping interactions have been shown to occur upon activation of the murine beta-globin locus, explaining the long-standing question of how gene regulatory elements can act at large genomic distances from their target genes.
DOI of Published Version
Trends Biochem Sci. 2003 Jun;28(6):277-80. Link to article on publisher's site
Trends in biochemical sciences
Dekker, Job, "A closer look at long-range chromosomal interactions" (2003). Program in Systems Biology Publications and Presentations. 6.