Worms, bacteria, and micronutrients: an elegant model of our diet
Program in Systems Biology; Program in Molecular Medicine
Bacteria | Biochemical Phenomena, Metabolism, and Nutrition | Genetics | Molecular Biology | Molecular, Genetic, and Biochemical Nutrition | Molecular Genetics | Systems Biology
Micronutrients are required in small proportions in a diet to carry out key metabolic roles for biomass and energy production. Humans receive micronutrients either directly from their diet or from gut microbiota that metabolize other nutrients. The nematode Caenorhabditis elegans and its bacterial diet provide a relatively simple and genetically tractable model to study both direct and microbe-mediated effects of micronutrients. Recently, this model has been used to gain insight into the relationship between micronutrients, physiology, and metabolism. In particular, two B-type vitamins, vitamin B12 and folate, have been studied in detail. Here we review how C. elegans and its bacterial diet provide a powerful interspecies systems biology model that facilitates the precise delineation of micronutrient effects and the mechanisms involved.
Caenorhabditis elegans, micronutrients, vitamin B, folate, gut microbiota, metabolism
DOI of Published Version
Trends Genet. 2014 Nov;30(11):496-503. doi: 10.1016/j.tig.2014.07.010. Epub 2014 Aug 26. Link to article on publisher's website
Trends in genetics : TIG
Yilmaz, L. Safak and Walhout, Albertha J. M., "Worms, bacteria, and micronutrients: an elegant model of our diet" (2014). Program in Systems Biology Publications and Presentations. 52.