Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy

UMMS Affiliation

Program in Systems Biology; Program in Molecular Medicine

Publication Date


Document Type



Cellular and Molecular Physiology | Endocrinology | Genetics and Genomics | Molecular Biology | Molecular, Genetic, and Biochemical Nutrition | Systems Biology


Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control of metabolic enzymes. Here, we discuss recent insights regarding metazoan metabolic regulatory networks using the nematode Caenorhabditis elegans as a model, including the modular organization of metabolic gene regulatory networks, the prominent impact of diet on the transcriptome and metabolome, specialized roles of nuclear hormone receptors (NHRs) in responding to dietary conditions, regulation of metabolic genes and metabolic regulators by miRNAs, and feedback between metabolic genes and their regulators.

DOI of Published Version



Watson E, Walhout AJ. Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy. Trends Endocrinol Metab. 2014 Oct;25(10):502-8. doi: 10.1016/j.tem.2014.03.004. Epub 2014 Apr 12. Link to article on publisher's site

Journal/Book/Conference Title

Trends in endocrinology and metabolism: TEM

Related Resources

Link to Article in PubMed

PubMed ID