Title
Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy
UMMS Affiliation
Program in Systems Biology; Program in Molecular Medicine
Publication Date
2014-10
Document Type
Article
Disciplines
Cellular and Molecular Physiology | Endocrinology | Genetics and Genomics | Molecular Biology | Molecular, Genetic, and Biochemical Nutrition | Systems Biology
Abstract
Diet greatly impacts metabolism in health and disease. In response to the presence or absence of specific nutrients, metabolic gene regulatory networks sense the metabolic state of the cell and regulate metabolic flux accordingly, for instance by the transcriptional control of metabolic enzymes. Here, we discuss recent insights regarding metazoan metabolic regulatory networks using the nematode Caenorhabditis elegans as a model, including the modular organization of metabolic gene regulatory networks, the prominent impact of diet on the transcriptome and metabolome, specialized roles of nuclear hormone receptors (NHRs) in responding to dietary conditions, regulation of metabolic genes and metabolic regulators by miRNAs, and feedback between metabolic genes and their regulators.
DOI of Published Version
10.1016/j.tem.2014.03.004
Source
Watson E, Walhout AJ. Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy. Trends Endocrinol Metab. 2014 Oct;25(10):502-8. doi: 10.1016/j.tem.2014.03.004. Epub 2014 Apr 12. Link to article on publisher's site
Journal/Book/Conference Title
Trends in endocrinology and metabolism: TEM
Related Resources
PubMed ID
24731597
Repository Citation
Watson E, Walhout AJ. (2014). Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy. Program in Systems Biology Publications. https://doi.org/10.1016/j.tem.2014.03.004. Retrieved from https://escholarship.umassmed.edu/sysbio_pubs/50