Program in Systems Biology; Program in Molecular Medicine; Department of Biochemistry and Molecular Pharmacology
RNA-Binding Proteins; Caenorhabditis elegans; RNA Processing, Post-Transcriptional; Gene Expression Regulation
Genetics and Genomics | Molecular Genetics | Systems Biology
Gene expression is regulated at multiple levels, including transcription and translation, as well as mRNA and protein stability. Although systems-level functions of transcription factors and microRNAs are rapidly being characterized, few studies have focused on the posttranscriptional gene regulation by RNA binding proteins (RBPs). RBPs are important to many aspects of gene regulation. Thus, it is essential to know which genes encode RBPs, which RBPs regulate which gene(s), and how RBP genes are themselves regulated. Here we provide a comprehensive compendium of RBPs from the nematode Caenorhabditis elegans (wRBP1.0). We predict that as many as 887 (4.4%) of C. elegans genes may encode RBPs ~250 of which likely function in a gene-specific manner. In addition, we find that RBPs, and most notably gene-specific RBPs, are themselves enriched for binding and modification by regulatory proteins, indicating the potential for extensive regulation of RBPs at many different levels. wRBP1.0 will provide a significant contribution toward the comprehensive delineation of posttranscriptional regulatory networks and will provide a resource for further studies regulation by RBPs.
Rights and Permissions
This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/ by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI of Published Version
G3 (Bethesda). 2013 Feb;3(2):297-304. doi: 10.1534/g3.112.004390. Link to article on publisher's site
G3 (Bethesda, Md.)
Tamburino AM, Ryder SP, Walhout AJ. (2013). A compendium of Caenorhabditis elegans RNA binding proteins predicts extensive regulation at multiple levels. Systems Biology Publications. https://doi.org/10.1534/g3.112.004390. Retrieved from https://escholarship.umassmed.edu/sysbio_pubs/23