The 4D nucleome project
Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology
Biophysics | Computational Biology | Genomics | Structural Biology | Systems Biology
The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.
Epigenomics, Gene regulation
DOI of Published Version
Nature. 2017 Sep 13;549(7671):219-226. doi: 10.1038/nature23884. Link to article on publisher's site
Dekker, Job; Belmont, Andrew S.; Guttman, Mitchell; Leshyk, Victor O.; Lis, John T.; Lomvardas, Stavros; Mirny, Leonid A.; O'Shea, Clodagh C.; Park, Peter J.; Ren, Bing; Ritland Politz, Joan C.; Shendure, Jay; Zhong, Sheng; and 4D Nucleome Network, "The 4D nucleome project" (2017). Program in Systems Biology Publications and Presentations. 115.