Title

The 4D nucleome project

UMMS Affiliation

Program in Systems Biology; Department of Biochemistry and Molecular Pharmacology

Publication Date

2017-09-13

Document Type

Article

Disciplines

Biophysics | Computational Biology | Genomics | Structural Biology | Systems Biology

Abstract

The 4D Nucleome Network aims to develop and apply approaches to map the structure and dynamics of the human and mouse genomes in space and time with the goal of gaining deeper mechanistic insights into how the nucleus is organized and functions. The project will develop and benchmark experimental and computational approaches for measuring genome conformation and nuclear organization, and investigate how these contribute to gene regulation and other genome functions. Validated experimental technologies will be combined with biophysical approaches to generate quantitative models of spatial genome organization in different biological states, both in cell populations and in single cells.

Keywords

Epigenomics, Gene regulation

DOI of Published Version

10.1038/nature23884

Source

Nature. 2017 Sep 13;549(7671):219-226. doi: 10.1038/nature23884. Link to article on publisher's site

Journal/Book/Conference Title

Nature

Related Resources

Link to Article in PubMed

PubMed ID

28905911

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