Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years
Department of Surgery
Adenocarcinoma; Adult; African Americans; Age of Onset; Aged; European Continental Ancestry Group; Female; *Hispanic Americans; Humans; Male; Middle Aged; *Neoplasm Metastasis; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Analysis
PURPOSE: To determine the clinicopathologic behavior of gastric adenocarcinoma in Hispanics by comparing Hispanic and non-Hispanic patients treated at a single cancer center.
PATIENTS AND METHODS: Medical records of patients with invasive gastric cancer treated from 1985 to 1999 were reviewed. Diagnoses were pathologically confirmed. Differences in categorical variables were assessed using the chi(2) test. Logistic regression was used for multivariate analyses. Median survival was estimated using the Kaplan-Meier method. Cox proportional hazards modeling was used to assess the impact of covariates.
RESULTS: Of 1,897 patients, 301 (15.9%) were Hispanic. Hispanics were significantly younger at diagnosis than non-Hispanic whites (53.1 +/- 14.4 years v 59.4 +/- 12.7 years, respectively; P < .005) or African Americans (57.6 +/- 15.3 years, P < .005). Hispanics were less likely to have proximal gastric cancers compared with whites (38.9% v 59.5%, respectively; P < .005). Hispanics were more likely to have mucinous/signet-ring type histology (42.5%) than whites (27.4%) and African Americans (32.5%; P < .005). Hispanics were more likely to require total gastrectomy (51%) compared with whites (38%), African Americans (38%), and Asians (36%; P = .039). Among patients with metastases at diagnosis, Hispanics were less likely to have liver metastasis than whites (30% v 44%, respectively; P = .009) but more likely to have peritoneal metastasis than whites and African Americans (54% v 41% and 47%, respectively; P = .002). In Cox analyses, Asian race, earlier stage, papillary/tubular histology, distal location, and younger age were favorable predictors of survival.
CONCLUSION: Hispanic ethnicity does not impact survival in gastric adenocarcinoma. However, histology, metastasis pattern, tumor localization, and other clinical parameters differ sufficiently to warrant further investigation into the epidemiology, pathogenesis, and molecular biology of gastric cancer in this population.
DOI of Published Version
J Clin Oncol. 2005 May 1;23(13):3094-103. Link to article on publisher's site
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Yao, James C.; Tseng, Jennifer F.; Worah, Samidha; Hess, Kenneth R.; Mansfield, Paul F.; Crane, Christopher H.; Schnirer, Isac I.; Reddy, Satish; Chiang, Silvia S.; Najam, Azmeena; Yu, Christina; Giacco, Geoffrey G.; Xie, Keping; Wu, Tsung-Teh; Feig, Barry W.; Pisters, Peter W. T.; and Ajani, Jaffer A., "Clinicopathologic behavior of gastric adenocarcinoma in Hispanic patients: analysis of a single institution's experience over 15 years" (2005). Surgery Publications and Presentations. 49.