Evolving Trends in Machine Perfusion for Liver Transplantation
Department of Surgery, Division of Organ Transplantation
Response or Comment
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Gastroenterology | Hepatology | Surgery
The imbalance between grafts available for transplantation and demands has moved the focus of many investigators on the search for novel strategies to rescue organs, previously considered to be unsuitable for transplantation. In this setting, machine perfusion is recognized as one of the most significant improvements in the field of transplantation over the past 20 years.Besides potentially improving organ shortage by repairing putative irreversible injuries, dynamic preservation strategies may offer an opportunity to test organ quality before implantation or to manipulate some functions; for example, by mitigating the immune response.
DOI of Published Version
Gastroenterology. 2019 May;156(6):1542-1547. doi: 10.1053/j.gastro.2018.12.037. Epub 2019 Jan 18. Link to article on publisher's site
Dutkowski, Phillipp; Guarrera, James V.; de Jonge, Jeroen; Martins, Paulo N.A.; Porte, Robert J.; and Clavien, Pierre-Alain, "Evolving Trends in Machine Perfusion for Liver Transplantation" (2019). Surgery Publications and Presentations. 176.