Normothermic machine preservation as an approach to decrease biliary complications of DCD liver grafts
Department of Surgery, Transplant and Hepatobiliary Surgery Division, UMass Memorial Medical Center
Letter to the Editor
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Surgery
Because of frequent biliary complications, it is crucial to develop new strategies to improve the quality of donors after cardiac death (DCD) liver grafts. I read with interest the article by Boehnert et al . The rate and severity of biliary epithelium damage they have reported after 60 min of warm ischemia and an additional 4–12 h of cold is extremely low compared to what has been published before and overestimates in large scale the potential benefit that machine perfusion can provide. They showed that despite this massive ischemic insult, four out of five DCD grafts on machine preservation had no detectable injury, with intact mucosa lining of the bile duct at the end of blood reperfusion, while the control group had 100% necrosis.
DOI of Published Version
Am J Transplant. 2013 Dec;13(12):3287-8. doi: 10.1111/ajt.12497. Epub 2013 Oct 21. Link to article on publisher's site
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Martins, Paulo N.A., "Normothermic machine preservation as an approach to decrease biliary complications of DCD liver grafts" (2013). Surgery Publications and Presentations. 172.