Thrombolytic protocol minimizes ischemic-type biliary complications in liver transplantation from donation after circulatory death donors

UMMS Affiliation

Department of Surgery

Publication Date


Document Type

Letter to the Editor


Analytical, Diagnostic and Therapeutic Techniques and Equipment | Cardiovascular System | Hepatology | Surgery


With interest, we have read the article by Seal et al. recently published in Liver Transplantation. The authors proposed that injection of tissue plasminogen activator, a potent thrombolytic agent, into the hepatic artery of donation after circulatory death (DCD) donor livers before transplantation reduces the incidence of biliary strictures after liver transplantation. We would like to challenge the basis for this potentially harmful therapy and wonder whether there is any evidence for the presence of thrombi in the biliary microcirculation of livers from DCD donors.

DOI of Published Version



Liver Transpl. 2015 Sep;21(9):1231-2. doi: 10.1002/lt.24185. Epub 2015 Jul 27. Link to article on publisher's site

Journal/Book/Conference Title

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

Related Resources

Link to Article in PubMed

PubMed ID