Thrombolytic protocol minimizes ischemic-type biliary complications in liver transplantation from donation after circulatory death donors
Department of Surgery
Letter to the Editor
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Cardiovascular System | Hepatology | Surgery
With interest, we have read the article by Seal et al. recently published in Liver Transplantation. The authors proposed that injection of tissue plasminogen activator, a potent thrombolytic agent, into the hepatic artery of donation after circulatory death (DCD) donor livers before transplantation reduces the incidence of biliary strictures after liver transplantation. We would like to challenge the basis for this potentially harmful therapy and wonder whether there is any evidence for the presence of thrombi in the biliary microcirculation of livers from DCD donors.
DOI of Published Version
Liver Transpl. 2015 Sep;21(9):1231-2. doi: 10.1002/lt.24185. Epub 2015 Jul 27. Link to article on publisher's site
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Burlage, Laura C.; Karangwa, Shanice A.; Lisman, Ton; Martins, Paulo N.A.; and Porte, Robert J., "Thrombolytic protocol minimizes ischemic-type biliary complications in liver transplantation from donation after circulatory death donors" (2015). Surgery Publications and Presentations. 166.