Department of Surgery, Division of Transplantation
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Digestive System | Hepatology | Surgery
There is a growing discrepancy between the supply and demand of livers for transplantation resulting in high mortality rates on the waiting list. One of the options to decrease the mortality on the waiting list is to optimize organs with inferior quality that otherwise would be discarded. Livers from donation after cardiac death (DCD) donors are frequently discarded because they are exposed to additional warm ischemia time, and this might lead to primary-non-function, delayed graft function, or severe biliary complications. In order to maximize the usage of DCD livers several new preservation approaches have been proposed. Here, we will review 3 innovative organ preservation methods: (1) different ex vivo perfusion techniques; (2) persufflation with oxygen; and (3) addition of thrombolytic therapy. Improvement of the quality of DCD liver grafts could increase the pool of liver graft's for transplantation, improve the outcomes, and decrease the mortality on the waiting list.
Biliary complications, Donation after cardiac death, Organ preservation methods
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
DOI of Published Version
World J Transplant. 2016 Jun 24;6(2):314-20. doi: 10.5500/wjt.v6.i2.314. Link to article on publisher's site
World journal of transplantation
Mahboub, Paria; Bozorgzadeh, Adel; and Martins, Paulo N.A., "Potential approaches to improve the outcomes of donation after cardiac death liver grafts" (2016). Surgery Publications and Presentations. 163.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License