Genetic and environmental factors in premenstrual symptom reporting and its relationship to depression and a general neuroticism trait

UMMS Affiliation

Department of Cell Biology

Publication Date


Document Type



Adolescent; Adult; Depressive Disorder; Diseases in Twins; Extraversion (Psychology); Female; Humans; Middle Aged; Models, Genetic; Neurotic Disorders; Personality Inventory; Premenstrual Syndrome; *Sick Role; *Social Environment; Twins, Dizygotic; Twins, Monozygotic


Cell Biology


Previous work has indicated a genetic contribution to premenstrual symptom reporting, regularity and menarche but no genetic contribution to cycle length, and no consistent genetic contribution to premenstrual symptom reporting. This paper reports the results (n = 634) of multivariate genetic analysis in which premenstrual symptom reporting is included in a general personality factor along with extroversion (E), neuroticism (N) and depression (D). The results showed that N, E, D and PMS all fitted on a common personality factor. There was no evidence for a specific genetic contribution of depression or premenstrual symptom reporting over and above those shown in the common personality factor. There were, however, unique/specific environmental contributions for PMS. For E and N, in contrast, both unique genetic and environmental contributions were apparent.


J Psychosom Res. 1995 May;39(4):477-87.

Journal/Book/Conference Title

Journal of psychosomatic research

Related Resources

Link to Article in PubMed

PubMed ID