Title
Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma
UMMS Affiliation
Department of Cell Biology
Publication Date
2011-04-03
Document Type
Article
Subjects
Oxidoreductases; Tumor Suppressor Proteins
Disciplines
Cell Biology
Abstract
Osteosarcoma is the most common primary bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and bone biology. WWOX is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma and a bone metabolic disease characterized by hypocalcemia and osteopenia. Studies of human osteosarcomas have revealed that the WWOX gene is deleted in 30% of cases and WWOX protein is absent or reduced in approximately 60% of tumors. Further, WWOX levels are attenuated in the majority of osteosarcoma cells, in which ectopic expression is associated with reduced proliferation, migration, invasion and tumorigenicity. At the molecular level, WWOX associates with RUNX2 and suppresses its transcriptional activity in osteoblasts and in cancer cells. This review provides new insights on the current knowledge of the spectrum of WWOX activities and future directions for the role of WWOX in bone biology and osteosarcoma.
Source
Am J Cancer Res. 2011;1(5):585-94. Epub 2011 Apr 3.
Journal/Book/Conference Title
American journal of cancer research
Related Resources
PubMed ID
21731849
Repository Citation
Del Mare, Sara; Kurek, Kyle C.; Stein, Gary S.; Lian, Jane B.; and Aqeilan, Rami I., "Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma" (2011). Stein, Stein, Lian, vanWijnen Lab Publications. 249.
https://escholarship.umassmed.edu/stein/249